Identification of Glucose-6-Phosphate Dehydrogenase (G6PD) Inhibitors by Cheminformatics Approach [0.03%]
基于化学信息学方法的葡萄糖-6-磷酸脱氢酶抑制剂识别研究
Srilatha Mundla,Madhu Sudhana Saddala
Srilatha Mundla
Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme in the pentose phosphate pathway (PPP), a critical glucose metabolism pathway linked to cancer cell proliferation and metastasis. Inhibiting the PPP presents a promising approa...
Investigation of Benzimidazole Derivatives in Molecular Targets for Breast Cancer Treatment: A Comprehensive Review [0.03%]
苯并咪唑衍生物作为乳腺癌治疗分子靶点的研究：综述性文章
Pratima Katiyar,Kalpana,Aditi Srivastava et al.
Pratima Katiyar et al.
This article provides a basic summary of computational research on benzimidazole and its molecular targets in breast cancer (BC) drug discovery. The drug development process is streamlined, expenses are decreased, and the possibility of fin...
Interaction of Heat Shock Protein 90 (HSP90), Ganetespib, and 5-Fluorouracil by Computational Approach for Colorectal Cancer Therapy [0.03%]
基于计算方法的热休克蛋白90(Ganetespib)与氟尿嘧啶相互作用治疗结直肠癌研究
Yuvasri Golivi,Santosh Kumar Behera,Afroz Alam et al.
Yuvasri Golivi et al.
The heat shock protein 90 kDa (HSP90) is highly conserved across diverse species, including humans, and upregulated in various cancers. As a result, it has been identified as a promising target for advancing anticancer medicine. The introdu...
Machine Learning Approaches for Neuroblastoma Risk Prediction and Stratification [0.03%]
用于神经母细胞瘤风险预测和分层的机器学习方法
Ramakrishna Vadde,Manoj Kumar Gupta
Ramakrishna Vadde
Machine learning (ML) holds great promise in advancing risk prediction and stratification for neuroblastoma, a highly heterogeneous pediatric cancer. By utilizing large-scale biological and clinical data, ML models can detect complex patter...
Pavithra Uppathi,Suraj Rajakumari,Kallimakula Venkareddy Saritha
Pavithra Uppathi
Molecular docking is a structure-based computational technique that plays a major role in drug discovery. Molecular docking enhances the efficacy of determining the metabolic interaction between two molecules, i.e., the small molecule (liga...
Kallimakula Venkareddy Saritha,Purnachandra Nagaraju Ganji
Kallimakula Venkareddy Saritha
The Role of TAMs in the Regulation of Tumor Cell Resistance to Chemotherapy [0.03%]
肿瘤相关巨噬细胞调控肿瘤细胞化疗耐药的作用机制研究进展
Ryan McWhorter,Benjamin Bonavida
Ryan McWhorter
Tumor-associated macrophages (TAMs) are the predominant cell infiltrate in the immunosuppressive tumor microenvironment (TME). TAMs are central to fostering pro-inflammatory conditions, tumor growth, metastasis, and inhibiting therapy respo...
Polarization of M2 Tumor-Associated Macrophages (TAMs) in Cancer Immunotherapy [0.03%]
肿瘤相关巨噬细胞(TAMs)的M2极化在癌症免疫治疗中的作用
Indy Bui,Benjamin Bonavida
Indy Bui
We have witnessed in the last decade new milestones in the treatment of various resistant cancers with new immunotherapeutic modalities. These advances have resulted in significant objective durable clinical responses in a subset of cancer ...
Targeting the Depletion of M2 Macrophages: Implication in Cancer Immunotherapy [0.03%]
针对M2型巨噬细胞耗竭的癌症免疫治疗策略研究进展
Talia Festekdjian,Benjamin Bonavida
Talia Festekdjian
We have witnessed the emergence of immunotherapy against various cancers that resulted in significant clinical responses and particularly in cancers that were resistant to chemotherapy. These milestones have ignited the development of novel...
Role of the Tumor Microenvironment in Mediating Resistance to Anti-HER2 Antibodies [0.03%]
肿瘤微环境在介导抗HER2抗体抵抗中的作用
Manoj Kumar Gupta,Gayatri Gouda,Ramakrishna Vadde
Manoj Kumar Gupta
Breast cancer (BC) is the most common cancer and the second leading cause of cancer-related deaths in women globally. Despite advancements in treatment strategies, many patients still develop challenging-to-treat metastatic disease. The dev...