A Sato,Y Sato
A Sato
Local metabolites have long been considered to play an important physiological role in regulating regional cerebral blood flow (rCBF). However, the evidence reviewed here emphasizes that the regulation of (rCBF) by central cholinergic nerve...
Kinetic analysis of regional (S)(-)11C-nicotine binding in normal and Alzheimer brains--in vivo assessment using positron emission tomography [0.03%]
动态分析尼古丁可逆结合位点在正常和阿尔茨海默氏病脑内的变化：体内正电子发射断层扫描评估
A Nordberg,H Lundqvist,P Hartvig et al.
A Nordberg et al.
A compartment model has been developed and validated for the kinetic analysis of (S)(-)11C-nicotine binding in the brain including a compensation for the influence of regional cerebral blood flow (rCBF). The model was applied to eight patie...
A M Kennedy,M N Rossor,R S Frackowiak
A M Kennedy
There is increasing evidence for genetic heterogeneity in Alzheimer disease. A longitudinal clinical and imaging study had been established in order to determine whether specific phenotypic profiles are present in aetiologically distinct fa...
Does early-onset Alzheimer disease constitute a distinct subtype? The contribution of molecular genetics [0.03%]
分子遗传学在早期发病阿尔茨海默病亚型中的作用
R J Harvey,M N Rossor
R J Harvey
Alzheimer disease (AD) is a clinical and pathologic diagnosis and refers to the findings of neurofibrillary tangles and amyloid plaques in the brain of a patient with dementia. Clinically it is recognized that there are familial and sporadi...
J O Brooks rd
J O Brooks rd
Subtypes of Alzheimer disease (AD) can be approached from different ways. An intuitive and commonly proposed subtype relates to the age at onset of disease. Research on age at onset as a subtype has yielded conflicting results that may, in ...
R D Terry
R D Terry
Large neurons shrink and synapses are lost in the neocortex as a function of normal aging, but different parts of the central nervous system vary in susceptibility to age changes. Thus, early-onset disease may appear different from late cas...
Is early-onset Alzheimer disease a distinct subgroup within the Alzheimer disease population? [0.03%]
早发性阿尔茨海默病是阿尔茨海默病的一个亚组吗？
M A Raskind,A Carta,D Bravi
M A Raskind
Although patients with Alzheimer disease (AD) share major clinical and neurohistologic features regardless of age of onset, the hypothesis that early-onset AD comprises a distinct subgroup remains viable. Most studies addressing this hypoth...
Identification of fast and slow decliners in Alzheimer disease: a different approach [0.03%]
阿尔茨海默病快速进展和缓慢进展患者的识别：另一种方法
J O Brooks rd,J A Yesavage
J O Brooks rd
As the body of knowledge about Alzheimer disease (AD) expands, more evidence is appearing to suggest the existence of different subtypes. The delineation of subtypes is important for a variety of reasons, and there are probably several ways...
Preliminary findings from the predictors study: utility of clinical signs for predicting disease course [0.03%]
预测研究的初步发现：临床症状对判断病情走势的价值
Y Stern,D M Jacobs
Y Stern
The aim of the Predictors Study is to develop a model of the progression of Alzheimer disease (AD) that can predict disease course in individual patients. This article reviews our recent work investigating the utility of extrapyramidal sign...
P J Whitehouse
P J Whitehouse