Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation [0.03%]
HDDD1家系额颞叶变性突触核蛋白阳性包涵体的异质性及早老素原蛋白基因突變
Maria I Behrens,Odity Mukherjee,Pang-hsien Tu et al.
Maria I Behrens et al.
Hereditary dysphasic disinhibition dementia (HDDD) describes a familial disorder characterized by personality changes, and language and memory deficits. The neuropathology includes frontotemporal lobar atrophy, neuronal loss and gliosis and...
ADCS Prevention Instrument Project: pilot testing of a book club as a psychosocial intervention and recruitment and retention strategy [0.03%]
ADCS防治工具项目：图书俱乐部作为心理社会干预和招募及保留策略的试点测试
Peter J Whitehouse,Julia L Rajcan,Susie A Sami et al.
Peter J Whitehouse et al.
Both psychosocial and biologic interventions may delay or prevent Alzheimer disease. Staying mentally active may help older people maintain their cognitive abilities. In the Alzheimer Disease Cooperative Study Prevention Instrument Project ...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S203-8. DOI:10.1097/01.wad.0000213876.70794.c6 2006
ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly [0.03%]
ADCS防治仪器项目：药物流行病学：评估健康老年患者的与健康相关的资源使用情况
Mary Sano,Carolyn W Zhu,Peter J Whitehouse et al.
Mary Sano et al.
Background: The Prevention Instrument project of the Alzheimer's Disease Cooperative Study (ADCS) seeks to develop instruments to assess treatment efficacy including potential economic benefit. The Resource Use Inventory ...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S191-202. DOI:10.1097/01.wad.0000213875.63171.87 2006
ADCS Prevention Instrument Project: quality of life assessment (QOL) [0.03%]
ADCS二级预防仪器项目：生活质量评估（QOL）
Marian B Patterson,Peter J Whitehouse,Steven D Edland et al.
Marian B Patterson et al.
Information about quality of life (QOL) is valuable in evaluating pharmaceutical agents but it is not adequately assessed in many dementia drug trials. In prevention trials, following participants to conversion to AD requires QOL scales app...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S179-90. DOI:10.1097/01.wad.0000213874.25053.e5 2006
ADCS Prevention Instrument Project: the Mail-In Cognitive Function Screening Instrument (MCFSI) [0.03%]
ADCS 预防项目：认知功能邮件筛查量表(MCFSI)
Sally P Walsh,Rema Raman,Katherine B Jones et al.
Sally P Walsh et al.
In future research on the prevention of Alzheimer Disease (AD), a large simple prevention trial might test a safe intervention (eg, vitamins) in a very large population (eg, 10,000 subjects), powered to detect a modest treatment effect size...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S170-8. DOI:10.1097/01.wad.0000213879.55547.57 2006
ADCS Prevention Instrument Project: assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials [0.03%]
痴呆预防临床试验中社区老年人能力定向的高级日常活动评估工具研发项目
Douglas Galasko,David A Bennett,Mary Sano et al.
Douglas Galasko et al.
Background: In primary prevention trials for Alzheimer disease, the inception cohort typically has normal or minimally impaired complex activities of daily living (ADL). ADL change during a trial could trigger detailed ev...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S152-69. DOI:10.1097/01.wad.0000213873.25053.2b 2006
ADCS Prevention Instrument Project: behavioral measures in primary prevention trials [0.03%]
ADCS一级预防测量学项目：行为量表
Jeffrey L Cummings,Rema Raman,Karin Ernstrom et al.
Jeffrey L Cummings et al.
Background: There is an urgent need for the development of inexpensive, reliable, and valid instruments that can be used in large-scale primary prevention trials of compounds aimed at ameliorating progression from normal ...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S147-51. DOI:10.1097/01.wad.0000213872.17429.0f 2006
ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials [0.03%]
痴呆症初级预防临床试验简易言语记忆测试研发项目
David P Salmon,Jeffrey L Cummings,Shelia Jin et al.
David P Salmon et al.
The validity and reliability of clinic-based and telephone-based versions of a 4 word delayed recall test were evaluated in nondemented elderly individuals (n=644) participating in a simulated primary prevention clinical trial. There was no...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S139-46. DOI:10.1097/01.wad.0000213871.40300.68 2006
ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions [0.03%]
阿尔茨海默病协调中心预防项目：阿尔茨海默病协调中心-临床医师对总体变化的全球评价量表（ADCS-CGIC）及其自我评估和研究伙伴评估版本
Lon S Schneider,Christopher M Clark,Rachelle Doody et al.
Lon S Schneider et al.
Background: Because primary prevention trials will require large samples and modest treatment effects are expected, the use of standard clinician-administered, clinic-based measures are unlikely to be feasible. There is a...
Steven H Ferris,Paul S Aisen,Jeffrey Cummings et al.
Steven H Ferris et al.
One objective of the Alzheimer's Disease Cooperative Study (ADCS) is to develop new or improved instruments and assessment methods for evaluating treatment efficacy in Alzheimer disease (AD) clinical trials. The ADCS Instrument Committee ha...
Randomized Controlled Trial
Alzheimer disease and associated disorders. 2006 Oct-Dec;20(4 Suppl 3):S109-23. DOI:10.1097/01.wad.0000213870.40300.21 2006