A model for management of behavioral symptoms in frontotemporal lobar degeneration [0.03%]
行为异常的管理模型- frontal temporal lobe 病变案例分析
Jennifer Merrilees
Jennifer Merrilees
Frontotemporal lobar degeneration is a neurologic condition that manifests profound behavioral, personality, and language symptoms. These changes, often unique to each person, may include social misconduct, eating disturbances, apathy, emot...
Longitudinal tracking of FTLD: toward developing clinical trial methodology [0.03%]
纵向追踪额颞叶痴呆：走向临床试验方法学开发
David S Knopman,Bradley S Boeve,Richard J Caselli et al.
David S Knopman et al.
Putative treatments for the frontotemporal lobar degenerations are likely to become available for testing in clinical trials in the next few years. To design clinical trials for this group of disorders, a number of conceptual, methodologic,...
Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution [0.03%]
行为变异型额颞叶痴呆和阿尔茨海默病中不同的社会功能障碍：互反网络与神经元进化方向的差异
William W Seeley,John M Allman,Danielle A Carlin et al.
William W Seeley et al.
Behavioral variant frontotemporal dementia (bvFTD) disrupts our most human social and emotional functions. Early in the disease, patients show focal anterior cingulate cortex (ACC) and orbital frontoinsula (FI) degeneration, accentuated in ...
Andrew Kertesz
Andrew Kertesz
This historical summary follows the major conceptual developments of the cohesive rather than the fractionated view of the disease, named after Pick. Clinical and biologic evidence in favor the entity is discussed. The changing and prolifer...
Ian R A Mackenzie
Ian R A Mackenzie
There is increasing recognition of a clinical overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Recent advances in our understanding of the neuropathologic, biochemical, and genetic basis of these condit...
Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia [0.03%]
3R和4Rtau蛋白病型行为变异型额颞叶痴呆的临床特征及生存分析
William T Hu,Joseph E Parisi,David S Knopman et al.
William T Hu et al.
We compared the clinical characteristics of 3 repeat (3R) and 4 repeat (4R) tau-positive cases (tauopathies) presenting as behavior variant frontotemporal dementia (bv-FTD). We identified and retrospectively reviewed demographics and clinic...
Links between frontotemporal lobar degeneration, corticobasal degeneration, progressive supranuclear palsy, and amyotrophic lateral sclerosis [0.03%]
额颞叶变性、皮质基底节变性和进行性核上性麻痹与肌萎缩侧索硬化之间的联系
Bradley F Boeve
Bradley F Boeve
Frontotemporal lobar degeneration, corticobasal degeneration (CBD), progressive supranuclear palsy, and amyotrophic lateral sclerosis have been considered distinct clinicopathologic entities with few issues in common other than neurodegener...
Identification and characterization of frontal lobe degeneration: historical perspective on the development of FTD [0.03%]
额叶变性的识别与特征：FTD发展的历史视角
Arne Brun
Arne Brun
This is a historical account of the development of the concept frontotemporal dementia, beginning with our discovery in the late 60s of a simple degenerative form. It was named frontal lobe degeneration of non-Alzheimer type to clearly sepa...
Progressive nonfluent aphasia and its characteristic motor speech deficits [0.03%]
进行性非流畅性失语症及其特征性的运动性构音障碍
Jennifer M Ogar,Nina F Dronkers,Simona M Brambati et al.
Jennifer M Ogar et al.
Progressive nonfluent aphasia (PNFA) is a clinical syndrome characterized by motor speech impairment and agrammatism, with relative sparing of single word comprehension and semantic memory. PNFA has been associated with the characteristic p...
Frontotemporal dementia and semantic dementia: anatomic variations on the same disease or distinctive entities? [0.03%]
frontal lobe颞叶痴呆和语义性痴呆：同一种病的解剖变异体还是具有区别的疾病实体？
Bruce L Miller
Bruce L Miller
Research into the non-Alzheimer dementias has exploded over the last 2 decades, and frontotemporal lobar degeneration has emerged as the most common cause of dementia in patients below the age of 65. In 1998, an international consortium of ...