The effect of a memory screening program on the early diagnosis of Alzheimer disease [0.03%]
记忆筛选项目对阿尔茨海默病早期诊断的影响
Warren W Barker,Cheryl Luis,Dylan Harwood et al.
Warren W Barker et al.
Context: Alzheimer Disease (AD) is often diagnosed at a moderately advanced stage, even though its early detection has become increasingly important, because of the continuing development of treatments that may improve it...
The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database [0.03%]
美国国家阿尔茨海默病协调中心（NACC）数据库：一个阿尔茨海默病的数据库
Duane L Beekly,Erin M Ramos,Gerald van Belle et al.
Duane L Beekly et al.
The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of patient information collected from the 29 Alzheimer disease centers (ADCs) funded by the National Institute on Aging. Each of th...
Expression profiling and pharmacotherapeutic development in the central nervous system [0.03%]
中枢神经系统的表达谱分析及药理治疗学研究
James E Galvin,Stephen D Ginsberg
James E Galvin
Expression profiling data is available for many diverse tissues throughout the body, allowing for exciting hypothesis testing of critical concepts such as cellular development, differentiation, normative function, and disease pathogenesis. ...
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells [0.03%]
含斑马鱼淀粉样前体蛋白的Sf9细胞匀浆中的CHAPSO半胱氨酸富集天冬氨酸蛋白酶活性分析
Troy L Carter,Giuseppe Verdile,David Groth et al.
Troy L Carter et al.
Presenilins are polytopic, integral proteins that control intramembranous proteolysis at the "gamma-" and "epsilon-" cleavage sites of the Alzheimer amyloid-beta precursor protein (APP) to yield amyloid-beta peptide (Abeta) and the APP intr...
Case series of clinically probable dementia with Lewy bodies in two Native Americans [0.03%]
两个土著美国人源性路易体痴呆临床病例系列
Marwan N Sabbagh,Nina B Silverberg,Douglas Walker et al.
Marwan N Sabbagh et al.
While incidence and prevalence of dementias have been assessed in some tribes, little is known about whether the different types of dementias that affect whites also affect Native Americans. Here, we report 2 cases of clinically probable de...
Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease [0.03%]
巴伐利亚家系中阿尔茨海默病的新PS1基因突变
Hans H Klünemann,Ekaterina Rogaeva,Manuela Neumann et al.
Hans H Klünemann et al.
We describe a novel Leu174Arg PS1 mutation in two members of a Bavarian family which were initially diagnosed with frontotemporal dementia. Intriguingly, there is the possibility that there is an 18th century founder effect and that this fa...
Factors influencing appraisal of upset in black caregivers of persons with Alzheimer disease and related dementias [0.03%]
影响非裔美国人照料者对其照顾的阿尔茨海默病及相关痴呆患者痛苦情绪评价的因素分析
Susan Toth-Cohen
Susan Toth-Cohen
Black caregivers of persons with Alzheimer disease and related dementias (ADRD) have demonstrated significantly lower levels of stress and burden than white caregivers, as measured by instruments that assess caregiving burden and stressfuln...
R Nitrini,P Caramelli,E Herrera Jr et al.
R Nitrini et al.
The authors report the incidence of dementia in a community-dwelling Brazilian population. In 1997, 1656 individuals aged 65 years or more, the majority being of very low educational level, were screened at their homes in Catanduva, Brazil,...
The Alzheimer's Disease Assessment Scale-Cognitive subscale: normative data for older adult controls [0.03%]
阿尔茨海默氏病评定量表-认知亚量表：老年对照组的正常数据
David P Graham,Jeffrey A Cully,A Lynn Snow et al.
David P Graham et al.
The Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-cog) is commonly used to assess cognitive dysfunction in individuals with Alzheimer disease and other dementias. The purpose of this study was to provide normative scores for...