The emotional impact of psychiatric symptoms in dementia on partner caregivers: do caregiver, patient, and situation characteristics make a difference? [0.03%]
痴呆患者的精神病症状对其照料配偶的情感影响：照护者、患者和情境特征的影响不同吗？
Franka J M Meiland,Martin G Kat,Willem van Tilburg et al.
Franka J M Meiland et al.
This study aims to investigate the emotional impact of psychiatric symptoms of patients with dementia on their caregiving partners, and to explore if caregiver, patient, and situation factors predict this emotional impact on caregivers. A c...
The validation of a caregiver assessment of dementia: the Dementia Severity Scale [0.03%]
痴呆严重程度量表的验证研究：一种照护者的评估方法
Philip D Harvey,Patrick J Moriarty,Leah Kleinman et al.
Philip D Harvey et al.
Objective: The objective of this study was to refine and validate the Dementia Severity Scale (DSS), a newly developed assessment of dementia severity from a caregiver's perspective. The Dementia Severity Scale is designe...
Encarnita R Ampil,Stephanie Fook-Chong,Swati N Sodagar et al.
Encarnita R Ampil et al.
The diversity of Singapore's population affords a unique opportunity to study ethnic variability in the dementias. We sought to explore the effects of ethnicity on the frequency of Alzheimer disease and vascular dementia in a large Singapor...
Survival among patients with dementia from a large multi-ethnic population [0.03%]
多民族人群中的痴呆患者的生存率研究
Stephen C Waring,Rachelle S Doody,Valory N Pavlik et al.
Stephen C Waring et al.
Survival among patients with dementia is critical information needed for planning and assessing the overall impact of dementia. Attrition from longitudinal cohorts often limits the confidence in survival estimates. For this study, we examin...
Effects of epitopes combination and adjuvants on immune responses to anti-Alzheimer disease DNA vaccines in mice [0.03%]
抗阿尔茨海默病DNA疫苗中表位组合及佐剂对免疫反应的影响
Ying He,Shu-Han Sun,Rui-Wen Chen et al.
Ying He et al.
Alzheimer disease (AD) is a neurodegenerative disorder characterized by neuropathological hallmarks including deposits of the beta-amyloid peptide (AssP). Studies have shown that immunization with Abeta42 peptide reduces both the spatial me...
Semantic dementia and primary progressive aphasia: a problem of categorization? [0.03%]
语义性痴呆和进行性失语症：一个分类问题吗？
Jonathan A Knibb,John R Hodges
Jonathan A Knibb
The relationship between semantic dementia (SD) and primary progressive aphasia (PPA) has been the subject of debate ever since the syndromes were first described, in converging streams of research from the neuropsychological and neurologic...
Autosomal dominant inclusion body myopathy, Paget disease of bone, and frontotemporal dementia [0.03%]
遗传性包涵体肌病伴骨Paget病和额颞叶痴呆
Virginia E Kimonis,Giles D J Watts
Virginia E Kimonis
Autosomal dominant proximal limb girdle or inclusion body myopathy, associated with Paget disease of bone and frontotemporal dementia (IBMPFD) is a recently described disorder that maps to chromosome 9p21.1-p12. We refined the critical locu...
Ubiquitin immunohistochemistry of frontotemporal lobar degeneration differentiates cases with and without motor neuron disease [0.03%]
泛素免疫组化鉴别额颞叶变性是否合并运动神经元病病理指标的研究
Omi Katsuse,Dennis W Dickson
Omi Katsuse
Frontotemporal lobar degeneration (FTLD) without tau pathology is clinically and pathologically heterogeneous. The present report describes the neuropathology of 52 brains with FTLD without tau pathology compared with 10 brains of amyotroph...
Adam L Boxer,Bruce L Miller
Adam L Boxer
What was once called Pick's disease has three major anatomic variants. With all three, frontotemporal brain is selectively injured whereas posterior cortical regions are spared. These three clinical patterns include a bifrontal, slightly as...
Amar Kar,David Kuo,Rongqiao He et al.
Amar Kar et al.
A number of neurodegenerative diseases are characterized by the presence of abundant deposits containing Tau protein. Expression of the human tau gene is under complex regulation. Mutations in the tau gene have been identified in patients w...