The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older women [0.03%]
老年妇女的自报睡眠时长、入睡困难和打鼾与认知功能的关系
Shelley S Tworoger,Sunmin Lee,Eva S Schernhammer et al.
Shelley S Tworoger et al.
We examined the association of sleep duration, snoring, and difficulty sleeping with cognitive function in a cohort of community-dwelling women. Women (n = 1844), aged 70 to 81 years at initial cognitive interview in 2000, are members of th...
Kate E Webster,John R Merory,Joanne E Wittwer
Kate E Webster
Studies have shown that measures of gait variability are associated with falling in older adults. However, few studies have measured gait variability in people with Alzheimer disease, despite the high incidence of falls in Alzheimer disease...
Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life [0.03%]
中年低血钾与晚年脑脊液中β淀粉样蛋白减少有关联
Michelle M Mielke,Peter P Zandi,Kaj Blennow et al.
Michelle M Mielke et al.
Low serum potassium increases risk of hypertension and stroke, and cardiovascular factors increase the risk of Alzheimer disease (AD). We examined the association between serum potassium and the biologic marker cerebrospinal fluid amyloid-b...
Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date [0.03%]
美金刚用于中重度阿尔茨海默病的有效性和安全性：迄今的证据
Roger Bullock
Roger Bullock
Memantine, a moderate-affinity, uncompetitive N-methyl-D-aspartate receptor antagonist, is currently the only agent approved for moderately severe to severe Alzheimer disease (AD) in Europe and for moderate-to-severe Alzheimer disease in th...
The characteristics of patients with uncertain/mild cognitive impairment on the Alzheimer disease assessment scale-cognitive subscale [0.03%]
阿尔茨海默病评估量表-认知分量表上表现轻度/疑似轻度认知损害的病人特征分析
Geunyeong Pyo,Rodger J Elble,Thomas Ala et al.
Geunyeong Pyo et al.
The performances of the uncertain/mild cognitive impairment (MCI) patients on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog) subscale were compared with those of normal controls, Alzheimer disease patients with CDR 0.5, and Alz...
Leon J Thal,Kejal Kantarci,Eric M Reiman et al.
Leon J Thal et al.
Biomarkers are likely to be important in the study of Alzheimer disease (AD) for a variety of reasons. A clinical diagnosis of Alzheimer disease is inaccurate even among experienced investigators in about 10% to 15% of cases, and biomarkers...
Two decades of research in Alzheimer disease: looking back to the first volume of ADAD [0.03%]
阿尔茨海默病研究20年：回溯ADAD首卷论文
Lissy F Jarvik,Steven S Matsuyama
Lissy F Jarvik
During the first two decades of the life of this Journal (ADAD) much progress has been made in our understanding of Alzheimer disease (AD). Advancing knowledge, however, has been accompanied by increasing appreciation of the complexity and ...
Drug development, clinical trials, cultural heterogeneity in Alzheimer disease: the need for pro-active recruitment [0.03%]
药物开发、临床试验及阿尔茨海默病中文化异质性的需求：积极招募的必要性
Lon S Schneider
Lon S Schneider
This article discusses the development of drugs and treatments in the context of issues of genetics, ethnicity, and culture. A brief overview of drug development, clinical trials methods, advertising and marketing practices, and the Alzheim...
Screening for cognitive impairment and depression in ethnically diverse older populations [0.03%]
族裔多元的老年群体中的认知障碍和抑郁筛查
Mary Ganguli,Hugh C Hendrie
Mary Ganguli
Considerable advances have been made over the past decade in developing and adapting instruments to measure cognitive functioning in individuals with a wide range of educational and racial/ethnic backgrounds in different countries. Similar ...
Cultural factors in dementia: perspectives from the anthropology of aging [0.03%]
文化在痴呆症中的因素——来自老年学人类学的观点
J Neil Henderson,John W Traphagan
J Neil Henderson
The plasticity of cultural constructs of dementia is shown in two societies: Japan, and an American Indian nation. By demedicalizing the analysis of dementia, the social and cultural factors that influence recognition of symptoms, help-seek...