Systematic review of the optimal frequency of follow-up in persons with mild dementia who continue to drive [0.03%]
轻度痴呆并继续驾驶的患者随访频率的系统评价
Frank J Molnar,Akhilesh Patel,Shawn C Marshall et al.
Frank J Molnar et al.
Fitness-to-drive guidelines commonly indicate that persons with mild dementia may be safe to drive but that periodic reevaluation is required. This paper presents the findings of a systematic review of primary evidence regarding the optimal...
Characterization of the kindred of Alois Alzheimer's patient with plaque-only dementia [0.03%]
阿尔茨海默病斑块型痴呆患者的家系特征分析
Hans H Klünemann,Wolfgang Fronhöfer,Doris Werner-Füchtenbusch et al.
Hans H Klünemann et al.
We describe the kindred of Alois Alzheimer's second published patient (Johann F.) with the brain pathology typical of a subgroup of Alzheimer disease called "plaque-only type." The genealogic records of the kindred extend back to 1670. We c...
Health problems and correlates of pain in nursing home residents with advanced dementia [0.03%]
机构中晚期痴呆患者的疼痛及相关问题
Betty S Black,Thomas Finucane,Alva Baker et al.
Betty S Black et al.
This study describes the health problems and comorbid illnesses of nursing home (NH) residents with advanced dementia (n=123) and identifies correlates of staff-identified pain. Study participants were residents of 3 NHs in Maryland, their ...
Efficacy of recreational and occupational activities associated to psychologic support in mild to moderate Alzheimer disease: a multicenter controlled study [0.03%]
轻至中度阿尔茨海默病患者与心理支持相关的休闲和职业活动效果的多中心对照研究
Elisabetta Farina,Federica Mantovani,Raffaella Fioravanti et al.
Elisabetta Farina et al.
We evaluated the efficacy of a stimulation program mainly based on recreational and occupational activities, associated with a brief cycle of support psychotherapy for patients and caregivers, in mild to moderate Alzheimer Disease (AD) asso...
A phase 2 study of tramiprosate for cerebral amyloid angiopathy [0.03%]
关于tramiprosate治疗脑淀粉样血管病的2期研究
Steven M Greenberg,Jonathan Rosand,Alexander T Schneider et al.
Steven M Greenberg et al.
Background and purpose: No treatments have been identified to lower the risk of intracerebral hemorrhage due to cerebral amyloid angiopathy (CAA). A potential approach to prevention is the use of agents that interfere wit...
Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment [0.03%]
中度至重度阿尔茨海默病日常活动能力的研究：分析稳定他克林治疗患者的美金刚疗效
Howard H Feldman,Frederick A Schmitt,Jason T Olin;Memantine MEM-MD- Study Group
Howard H Feldman
In moderate-to-severe Alzheimer disease (AD), there are significant losses of activities of daily living (ADL). In a recent prospective, randomized, placebo-controlled trial, memantine treatment lessened the overall functional decline in AD...
Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis [0.03%]
多奈哌齐治疗的中重度阿尔茨海默病患者认知反应型对美金刚的认知反应：一项探索性再分析
Frederick A Schmitt,Christopher H van Dyck,Christine H Wichems et al.
Frederick A Schmitt et al.
Objective: To investigate the cognitive effects of the N-methyl-D-aspartate receptor antagonist, memantine, with a post-hoc exploratory reanalysis of a 24-week randomized, double-blind, placebo-controlled, parallel group ...
Relationship between the efficacy of rivastigmine and apolipoprotein E (epsilon4) in patients with mild to moderately severe Alzheimer disease [0.03%]
Rivastigmin治疗轻至中重度阿尔茨海默病疗效与载脂蛋白E（ε4）的关系研究
Rafael Blesa,Miquel Aguilar,Jordi Peña Casanova et al.
Rafael Blesa et al.
Alzheimer disease is the most common form of dementia in Western countries and the leading cause of disability in the over-65 population. Apolipoprotein E (APOE) is a multifunctional protein implied in lipid metabolism and neurobiology. Pol...
Thyroid function in patients with Alzheimer disease: implications on response to anticholinesterase treatment [0.03%]
阿尔茨海默病患者的甲状腺功能及其对胆碱酯酶抑制剂治疗反应的影响
Elisabeth Kapaki,George P Paraskevas,Emily Mantzou et al.
Elisabeth Kapaki et al.
Increasing evidence supports an extensive interrelationship between thyroid hormones and the cholinergic system, which is selectively and early affected in Alzheimer disease (AD). The aim of the present study was to explore thyroid function...
Spanish instrument protocol: new treatment efficacy instruments for Spanish-speaking patients in Alzheimer disease clinical trials [0.03%]
阿尔茨海默病临床试验中的西班牙语评估工具：用于说西班牙语患者的新型疗效评估仪器开发方案
Mary Sano,Susan Egelko,Shelia Jin et al.
Mary Sano et al.
Objective: To evaluate the feasibility of longitudinal assessment and the psychometric properties of both established and new outcome measures used in clinical trials of patients with dementia in a cohort of Spanish-speak...