Functional protofilament numbering of ciliary, flagellar, and centriolar microtubules [0.03%]
纤毛、鞭毛和中心体微管的功能原纤维编号法
Richard W Linck,Raymond E Stephens
Richard W Linck
This article discusses the current state of knowledge about the evolutionarily conserved structure of ciliary, flagellar and centriolar microtubules, and formally proposes a functional numbering convention for their protofilaments.
Molecular identification and localization of cellular titin, a novel titin isoform in the fibroblast stress fiber [0.03%]
细胞应力纤维中的新型Titin同种型的分子鉴定与定位
Peter J Cavnar,Scott G Olenych,Thomas C S Keller rd
Peter J Cavnar
We previously discovered a large titin-like protein-c-titin-in chicken epithelial brush border and human blood platelet extracts that binds alpha-actinin and organizes arrays of myosin II bipolar filaments in vitro. RT-PCR analysis of total...
Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex [0.03%]
Gas11与微管的直接相互作用：对动力蛋白调节复合物的意义
Janine M Bekker,Jessica R Colantonio,Andrew D Stephens et al.
Janine M Bekker et al.
We previously described the Trypanin family of cytoskeleton-associated proteins that have been implicated in dynein regulation [Hill et al., J Biol Chem2000; 275(50):39369-39378; Hutchings et al., J Cell Biol2002;156(5):867-877; Rupp and Po...
Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells [0.03%]
分析RAB27A在视网膜色素上皮细胞中连接MYRIP和MYO7A到黑色素体
Adriana E Klomp,Karen Teofilo,Erin Legacki et al.
Adriana E Klomp et al.
The apical region of the retinal pigment epithelium (RPE) typically contains melanosomes. Their apical distribution is dependent on RAB27A and the unconventional myosin, MYO7A. Evidence from studies using in vitro binding assays, melanocyte...
Microtubules' interaction with cell cortex is required for their radial organization, but not for centrosome positioning [0.03%]
细胞皮层与微管的相互作用要求其径向组织，但并非中心体定位所必需
I B Brodsky,A V Burakov,E S Nadezhdina
I B Brodsky
Microtubules in interphase mammalian cells usually form a radial array with minus-ends concentrated in the central region and plus-ends placed at the periphery. This is accepted as correct, that two factors determinate the radial organizati...
Microtubule-binding proteins CLASP1 and CLASP2 interact with actin filaments [0.03%]
与微管结合的蛋白质CLASP1和CLASP2与肌动蛋白丝相互作用
Andrey S Tsvetkov,Andrey Samsonov,Anna Akhmanova et al.
Andrey S Tsvetkov et al.
Cell morphogenesis requires dynamic communication between actin filaments and microtubules which is mediated, at least in part, by direct structural links between the two cytoskeletal systems. Here, we examined interaction between the CLIP-...
Development of micropost force sensor array with culture experiments for determination of cell traction forces [0.03%]
基于培养实验的微柱阵列力传感器芯片的研究及制备细胞牵引力大小及分布的新方法
Bin Li,Luke Xie,Zane C Starr et al.
Bin Li et al.
Cell traction forces (CTFs) are critical for cell motility and cell shape maintenance. As such, they play a fundamental role in many biological processes such as angiogenesis, embryogenesis, inflammation, and wound healing. To determine CTF...
Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture [0.03%]
Rho在三维培养中调节局部细胞-基质机械相互作用中发挥核心作用
N Lakshman,A Kim,K J Bayless et al.
N Lakshman et al.
The purpose of this study was to assess quantitatively the role of the small GTPase Rho on cell morphology, f-actin organization, and cell-induced matrix remodeling in 3D culture. Human corneal fibroblasts (HTK) were infected with adenoviru...
Rearrangement of microtubule polarity orientation during conversion of dendrites to axons in cultured pyramidal neurons [0.03%]
培养的锥体神经元中树突转化为轴突时微管极性重组现象的研究
Daisuke Takahashi,Wenqian Yu,Peter W Baas et al.
Daisuke Takahashi et al.
Axons and dendrites of neurons differ in the polarity orientation of their microtubules. Whereas the polarity orientation of microtubules in axons is uniform, with all plus ends distal, that in dendrites is nonuniform. The mechanisms respon...
The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development [0.03%]
聋鼠突变体whirler表明whirlin在肌动蛋白丝动力学和静纤毛发育中的作用
Mette M Mogensen,Agnieszka Rzadzinska,Karen P Steel
Mette M Mogensen
Stereocilia, finger-like projections forming the hair bundle on the apical surface of sensory hair cells in the cochlea, are responsible for mechanosensation and ultimately the perception of sound. The actin cytoskeleton of the stereocilia ...