Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle [0.03%]
骨骼肌中的新型肌动蛋白丝与正常和患病肌肉的肌肉重塑/再生有关
Nicole Vlahovich,Galina Schevzov,Visalini Nair-Shaliker et al.
Nicole Vlahovich et al.
The organisation of structural proteins in muscle into highly ordered sarcomeres occurs during development, regeneration and focal repair of skeletal muscle fibers. The involvement of cytoskeletal proteins in this process has been documente...
Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein [0.03%]
Lasp-2的表达、定位及其配体相互作用：一个新的Z线结构蛋白
Anke Zieseniss,Asako G Terasaki,Carol C Gregorio
Anke Zieseniss
The nebulin family of actin-binding proteins plays an important role in actin filament dynamics in a variety of cells including striated muscle. We report here the identification of a new striated muscle Z-disc associated protein: lasp-2 (L...
Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition [0.03%]
肌细胞中的myoseverin能破坏 sarcomere的组织结构：与抑制微管装配无关的一种效应
Dominic C H Ng,Bijanka L Gebski,Miranda D Grounds et al.
Dominic C H Ng et al.
Although disruption of the microtubule (MT) array inhibits myogenesis in myocytes, the relationship between the assembly of microtubules (MT) and the organization of the contractile filaments is not clearly defined. We now report that the a...
Comparative Study
Cell motility and the cytoskeleton. 2008 Jan;65(1):40-58. DOI:10.1002/cm.20242 2008
A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly [0.03%]
具有功能获得属性的FAK/Src嵌合体可促进大外围粘附斑的形成，从而促进动态肌动蛋白装配
Priscila M F Siesser,Leslie M Meenderink,Larisa Ryzhova et al.
Priscila M F Siesser et al.
Formation of a complex between the tyrosine kinases FAK and Src is a key integrin-mediated signaling event implicated in cell motility, survival, and proliferation. Past studies indicate that FAK functions in the complex primarily as a "sca...
Novel application of flow cytometry: determination of muscle fiber types and protein levels in whole murine skeletal muscles and heart [0.03%]
流式细胞术的新应用：测定整个小鼠骨骼肌和心脏中肌肉纤维类型及蛋白水平
Connie Jackaman,Kristen J Nowak,Gianina Ravenscroft et al.
Connie Jackaman et al.
Conventional methods for measuring proteins within muscle samples such as immunohistochemistry and western blot analysis can be time consuming, labor intensive and subject to sampling errors. We have developed flow cytometry techniques to d...
Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas [0.03%]
肌球蛋白II活性及肌球蛋白轻链磷酸化的调控在神经胶质瘤中的作用
Bodour Salhia,Jeong Hyun Hwang,Christian A Smith et al.
Bodour Salhia et al.
The generation of contractile force mediated by actin-myosin interactions is essential for cell motility. Myosin activity is promoted by phosphorylation of myosin light chain (MLC). MLC phosphorylation in large part is controlled by kinases...
Peter Satir,Charles Guerra,Aaron J Bell
Peter Satir
The origin of cilia, a fundamental eukaryotic organelle, not present in prokaryotes, poses many problems, including the origins of motility and sensory function, the origins of nine-fold symmetry, of basal bodies, and of transport and selec...
Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cells [0.03%]
应力纤维远离粘着斑的移动表明粘着斑是静止细胞中应力纤维组装的部位
Nicole Endlich,Carol A Otey,Wilhelm Kriz et al.
Nicole Endlich et al.
Force generated in contractile actin filament bundles (stress fibers-SFs) is transmitted to the extracellular matrix (ECM) via linker proteins and transmembrane integrins at focal adhesions (FAs). Though it has long been known that actin is...
Caldesmon is necessary for maintaining the actin and intermediate filaments in cultured bladder smooth muscle cells [0.03%]
钙调蛋白对于维持膀胱平滑肌细胞中actin和中间纤维结构的稳定性是必需的
Maoxian Deng,Sunish Mohanan,Erzsebet Polyak et al.
Maoxian Deng et al.
Caldesmon (CaD), a component of microfilaments in all cells and thin filaments in smooth muscle cells, is known to bind to actin, tropomyosin, calmodulin, and myosin and to inhibit actin-activated ATP hydrolysis by smooth muscle myosin. Thu...
Kevin G Young,Rashmi Kothary
Kevin G Young
The dystonin/Bpag1 cytoskeletal interacting proteins play important roles in maintaining cytoarchitecture integrity in skin and in the neuromuscular system. The most profound phenotype observed in the dystonin mutant dystonia musculorum (dt...