Rab6 family proteins interact with the dynein light chain protein DYNLRB1 [0.03%]
Rab6蛋白家族与动力蛋白轻链蛋白DYNLRB1相互作用
Bas Wanschers,Rinske van de Vorstenbosch,Mietske Wijers et al.
Bas Wanschers et al.
The small GTPase Rab6 is a key regulator in the retrograde transfer from endosomes via the Golgi to the ER. Three isoforms of Rab6 have been identified, the ubiquitously expressed Rab6A and Rab6A', and the brain specific Rab6B. Recent studi...
Bor Luen Tang,Christelle En Lin Chua
Bor Luen Tang
The mammalian silent information regulator 2 (SIRT2) is an NAD-dependent histone deacetylase with known roles in the regulation of the cell cycle. SIRT2 is also a tubulin deacetylase functioning as an early mitotic checkpoint, but its roles...
Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells [0.03%]
肌球蛋白Va或重链HMMyoVa过表达对非肌肉细胞囊泡分布、细胞骨架排列及细胞运动的影响相反
Robbin D Eppinga,I-Feng Peng,Jenny Li-Chun Lin et al.
Robbin D Eppinga et al.
Myosin Va, an actin-based motor protein that transports intracellular cargos, can bundle actin in vitro. Whether myosin Va regulates cellular actin dynamics or cell migration remains unclear. To address this, we compared Chinese Hamster Ova...
M J Greenberg,C-L A Wang,W Lehman et al.
M J Greenberg et al.
The ability of cells to sense and respond to physiological forces relies on the actin cytoskeleton, a dynamic structure that can directly convert forces into biochemical signals. Because of the association of muscle actin-binding proteins (...
F Oeffner,C Moch,A Neundorf et al.
F Oeffner et al.
Bardet-Biedl syndrome (BBS) is a rare, developmental disorder characterized by six major symptoms: rod-cone dystrophy, obesity, polydactyly, renal abnormalities, learning difficulties, and hypogonadism. Secondary features include cardiac an...
Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: neurofilaments attenuate tau-mediated neurite instability [0.03%]
tau通过将货物有丝分裂电机解离为神经丝来抑制正向轴突运输并部分破坏生长轴突树突的稳定性：神经丝减轻了tau介导的神经元不稳定状态
Maya Dubey,Pulkit Chaudhury,Hilda Kabiru et al.
Maya Dubey et al.
Overexpression of tau compromises axonal transport and induces retraction of growing neurites. We tested the hypothesis that increased stability provided by neurofilaments (NFs) may prevent axonal retraction. NB2a/d1 cells were differentiat...
William B Holmes,Carole L Moncman
William B Holmes
The actin-binding proteins, nebulette, and nebulin, are comprised of a four-domain layout containing an acidic N-terminal region, a repeat domain, a serine-rich-linker region, and a Src homology-3 domain. Both proteins contain homologous N-...
Simulated microgravity activates MAPK pathways in fibroblasts cultured on microgrooved surface topography [0.03%]
模拟微重力激活微 grooved 表面拓扑结构上成纤维细胞中的 MAPK 途径
W A Loesberg,X F Walboomers,J J W A van Loon et al.
W A Loesberg et al.
This study evaluated in vitro the differences in morphological behaviour between fibroblast cultured on smooth and microgrooved substrata (groove depth: 0.5 mum, width: 1 mum), which were subjected to simulated microgravity. The aim of the ...
Emerging molecular mechanisms that power and regulate the anastral mitotic spindle of flowering plants [0.03%]
调控开花植物无星体有丝分裂纺锤体的分子机制
Alex Bannigan,Michelle Lizotte-Waniewski,Margaret Riley et al.
Alex Bannigan et al.
Flowering plants, lacking centrosomes as well as dynein, assemble their mitotic spindle via a pathway that is distinct visually and molecularly from that of animals and yeast. The molecular components underlying mitotic spindle assembly and...
In vivo phosphorylation of regulatory light chain of myosin II in sea urchin eggs and its role in controlling myosin localization and function during cytokinesis [0.03%]
海胆卵中肌动蛋白调节轻链的体内磷酸化及其在有丝分裂后期控制肌球蛋白定位和功能中的作用
Ryota Uehara,Hiroshi Hosoya,Issei Mabuchi
Ryota Uehara
Phosphorylation of myosin regulatory light chain (RLC) at Ser19 (mono-phosphorylation) promotes filament assembly and enhances actin-activated ATPase activity of non-muscle myosin, while phosphorylation at both Ser19 and Thr18 (di-phosphory...