IMMUNOTHERAPY OF BLADDER CANCER. BCG VACCINE: PRINCIPLES OF ACTION, EFFICACY AND SAFETY [0.03%]
膀胱癌的免疫治疗。卡介苗：作用原理、有效性和安全性
P V Glybochko,V P Fisenko
P V Glybochko
Data on the principles of BCG vaccine action on the cancer of bladder are presented. Probable targets for BCG vaccine are estimated. Efficacy of BCG vaccine in non-muscle invasive cancer of bladder is analyzed. Side effects of BCG vaccine a...
V P Fisenko,N G Bondarchuk
V P Fisenko
Various stages of life, scientific research and pedagogical activity of Prof. Mikhail P. Nikolaev are considered. The importance of his works in drug evaluation, endocrinological pharmacology, pharmacology of heart and vessels, pathological...
E V Shekunova,V A Kashkin,A A Muzhikyan et al.
E V Shekunova et al.
This work was aimed at comparative analysis of the two experimental models of chronic arthritis induced in rats by the administration of (i) complete Freund's adjuvant (CFA) and (ii) carrageenan. The clinical and histological signs of patho...
Comparative Study
Eksperimental'naia i klinicheskaia farmakologiia. 2016;79(10):22-28. DOI: 2016
EFFECT OF CARBAMAZEPINE ON THE ACTIVITY OF CYP3A4 ISOENZYME IN PATIENTS WITH ALCOHOL ADDICTION [0.03%]
卡马西平对酒精依赖患者CYP3A4亚型酶活性的影响
M S Zastrozhin,V V Simirnov,D A Sychev et al.
M S Zastrozhin et al.
According to literature data, isoenzyme CYP3A4 of cytochrome P450 is involved in biotransformation of drugs.,At the same time, there is evidence that carbamazepine induces CYP3A4 activity. The purpose of the study was to evaluate the effect...
EXPERIMENTAL ASSESSMENT OF THE SPECIFIC EFFICIENCY OF NEW METABOLIC DRUG RUNIKHOL ON MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE [0.03%]
新型代谢药物鲁尼霍尔针对非酒精性脂肪肝病模型的特异性效率评估实验
V V Stel&#x;makh,A P Trashkov,A L Kovalenko et al.
V V Stel&#x;makh et al.
We present results of preclinical evaluation of the specific efficiency of new metabolic corrector runikhol on models of non-alcoholic fatty liver disease in laboratory rats (228 albino males of gray Wistar rats weighing 220 - 240 g). The d...
PECULIARITIES OF THE EFFECT OF AMINOADAMANTANE DERIVATIVES ON ETHANOL-INDUCED ATAXIA. SEDATION. AND HYPERLOCOMOTION IN MICE [0.03%]
氨亚 adamantane 衍生物对乙醇致小鼠共济失调、镇静和高运动活动的影响的特征性效应
L G Kolik,A V Nadorova,E A Val&#x;dman et al.
L G Kolik et al.
The influence of two aminoadamantane derivatives representing low-affinity NMDA receptor antagonists, which show antiparkinsonian-like activity both in animal models and in patients with Parkinson's disease, have been studied in vivo on mic...
ANXIOLYTIC EFFECTS OF DIAZEPAM AND AFOBAZOLE ON THE ANXIETY RESPONSE EVOKED BY GABA(A) RECEPTOR BLOCKADE IN WISTAR RATS AND INBRED MICE OF Balb/c AND C57BI/6 STRAINS [0.03%]
地西泮和阿普唑仑对wistar大鼠及balb/c和c57bi/6品系小鼠γ-氨基丁酸a型受体阻断诱发的焦虑反应的影响研究
T S Kalinina,A A Shimshirt,A V Volkova et al.
T S Kalinina et al.
The anxyolitic effects of diazepam and afobazole on the anxiety model caused by subconvulsive doses of pentylenetetrazole have been studied in the open field test and drug discrimination in rodents. It is found that diazepam (I and 5 mg/kg,...
RNA INTERFERENCE: NEW APPROACH TO THE TREATMENT OF ALLERGIC ASTHMA (A REVIEW) [0.03%]
RNA干扰：治疗过敏性哮喘的新方法(综述)
I P Shilovskii,M S Prozorova,A R Gaisina et al.
I P Shilovskii et al.
Asthma is among the most common chronic disorders of airways, which affects both children and adults. Asthma being a common disease among different segments of population, it has a high mortality rate and, in the absence of appropriate care...
EFFECT OF 3-HYDROXYPYRIDINE AND SUCCINIC ACID DERIVATIVES ON BACTERIAL GROWTH IN DISCONTINUOUS CULTURES [0.03%]
3-羟基吡啶和丁二酸衍生物对间歇培养中细菌生长的影响
I A Volchegorskii,E V Pravdin,A V Pospelova et al.
I A Volchegorskii et al.
We have studied the effect of domestic derivatives of 3-hydroxypyridine and succinic acid (emoxipine, reamberin, and mexidol) on proliferation of E. coli, S. aureus and E. faecalis in discontinuous cultures (DCs) over a period of 1 or 24 h....
ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID [0.03%]
4-O-β-D-吡喃葡萄糖氧基苯甲酸钠的抗炎作用
T O Murashko,I V Simirnov,A A Bondarev et al.
T O Murashko et al.
We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into...