Synthesis and antiviral evaluation of 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl 2,6-disubstituted purine nucleosides [0.03%]
2',3'-二氟-2',3'-双脱氧-2,6-取代嘌呤核糖苷的合成及其抗病毒活性评价
Raymond F Schinazi,Grigorii G Sivets,Mervi A Detorio et al.
Raymond F Schinazi et al.
The synthesis of new 2,6-disubstituted purine 2',3'-dideoxy-2',3'-difluoro-D-arabino nucleosides is reported. Their ability to block HIV and HCV replication along with their cytotoxicity toward Huh-7 cells, human lymphocyte, CEM and Vero ce...
Synthesis of 3-benzylidene-dihydrofurochromen-2-ones: promising intermediates for biflavonoid synthesis [0.03%]
3-苯亚甲基二氢呋喃香豆素-2-酮的合成用于茋类黄酮合成的很有前景的中间体
Verna Baron,Keith T Mead
Verna Baron
A route to 3-benzylidene dihydrofurochromen-2-ones from 2H-chromenes is described. Lactonization of 2H-chromenes was achieved using a two-step cyclopropanation-rearrangement sequence. Subsequent conversion of these intermediates to the corr...
Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4 [0.03%]
作为趋化因子受体类型4拮抗剂的吡啶衍生物合成
Suazette Reid Mooring,Theresa Gaines,Zhongxing Liang et al.
Suazette Reid Mooring et al.
A series of pyridine derivatives were synthesized as potential inhibitors of chemokine receptor type 4. This chemokine receptor has been linked to various disease pathways including HIV-1 proliferation, autoimmune disorders, inflammatory di...
Ruben S Vardanyan,Gevork G Danagulyan,Armen D Mkrtchyan et al.
Ruben S Vardanyan et al.
The reaction of 4-amino-2-benzyl-1-methyl-5-ethoxycarbonylpyrimidinium iodide (3) with alcoholic methylamine resulted in the formation of the methylimine of 2-amino-4-hydroxy-6-methylamino-5-phenylpyridine-3-carbaldehyde (5). Heating of the...