Fine structure of the subitaneous eggshell of the sessile rotifer Stephanoceros millsii (Monogononta) with observations on vesicle trafficking in the integument during ontogeny [0.03%]
盘纤羽摇蚊卵壳亚显微结构及其外壳囊泡运输的观察
Rick Hochberg,Hui Yang,Elizabeth J Walsh et al.
Rick Hochberg et al.
Rotifers that engage in cyclical parthenogenesis produce two types of eggs: subitaneous eggs that hatch as clonal females and meiotic eggs that hatch as haploid males, or if fertilized, as females after a period of diapause (resting eggs). ...
Mahadev Murthy,Jeffrey L Ram
Mahadev Murthy
Invertebrate model systems, such as nematodes and fruit flies, have provided valuable information about the genetics and cellular biology involved in aging. However, limitations of these simple, genetically tractable organisms suggest the n...
Heidi A Tissenbaum
Heidi A Tissenbaum
Over a century ago, the zoologist Emile Maupas first identified the nematode, Rhabditis elegans, in the soil in Algiers. Subsequent work and phylogenic studies renamed the species Caenorhabditis elegans or more commonly referred to as C. el...
Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster [0.03%]
探索果蝇(Drosophila melanogaster)肠道衰老的生理和病理机制
Heinrich Jasper
Heinrich Jasper
The gastrointestinal tract, due to its role as a digestive organ and as a barrier between the exterior and interior milieus, is critically impacted by dietary, environmental, and inflammatory conditions that influence health and lifespan. W...
Roma Munday,Delany Rodriguez,Alessandro Di Maio et al.
Roma Munday et al.
What mechanisms underlie aging? One theory, the wear-and-tear model, attributes aging to progressive deterioration in the molecular and cellular machinery which eventually lead to death through the disruption of physiological homeostasis. T...
Anthony J Bellantuono,Diane Bridge,Daniel E Martínez
Anthony J Bellantuono
Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacem...
Botryllus schlosseri, an emerging model for the study of aging, stem cells, and mechanisms of regeneration [0.03%]
Botryllus schlossери成为衰老、干细胞和再生机制研究新模式动物的发展前景
Ayelet Voskoboynik,Irving L Weissman
Ayelet Voskoboynik
The decline of tissue regenerative potential with the loss of stem cell function is a hallmark of mammalian aging. We study Botryllus schlosseri, a colonial chordate which exhibits robust stem cell-mediated regeneration capacities throughou...
Independent chemical regulation of health and senescent spans in Drosophila [0.03%]
独立的化学调节可影响果蝇的健康寿命和衰老速率
Robert Arking
Robert Arking
Curcumin feeding of Drosophila larvae or young adults inhibits TOR and other known longevity genes and induces an extended health span in a normal-lived Ra strain adult. Combining larval curcumin feeding with an adult dietary restriction (D...
Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin [0.03%]
近乎无衰老的细胞及分子机制：海胆提供新见解
Andrea G Bodnar
Andrea G Bodnar
Sea urchins exhibit a very different life history from humans and short-lived model animals and therefore provide the opportunity to gain new insight into the complex process of aging. Sea urchins grow indeterminately, regenerate damaged ap...
Szymon Tomczyk,Kathleen Fischer,Steven Austad et al.
Szymon Tomczyk et al.
Cnidarian Hydra polyps escape senescence, most likely due to the robust activity of their three stem cell populations. These stem cells continuously self-renew in the body column and differentiate at the extremities following a tightly coor...