Pancreatic neuroendocrine neoplasms: current paradigms and diagnostic challenges [0.03%]
胰腺神经内分泌肿瘤：当前诊治模式与诊断挑战
Grace J Kwon,Chanjuan Shi
Grace J Kwon
Pancreatic neuroendocrine neoplasms (PanNENs) are broadly divided into well-differentiated pancreatic neuroendocrine tumors (PanNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs). Grading is based on the mitotic ...
Head and neck xanthogranulomatous epithelial tumors/keratin-positive giant cell-rich tumors [0.03%]
头颈部类上皮黄色肉芽肿样肿瘤/角蛋白阳性巨细胞丰富型肿瘤
Rumeal D Whaley
Rumeal D Whaley
Xanthogranulomatous epithelial tumor (XGET) and keratin-positive giant cell-rich tumor (KPGCT) represent ends along the spectrum of a single neoplastic entity, with overlapping clinical, morphologic, immunohistochemical, and genetic finding...
Adam C Seegmiller
Adam C Seegmiller
Multiparameter flow cytometry is an effective tool in the diagnosis and monitoring of plasma cell neoplasms such as multiple myeloma. This review focuses on how flow cytometry can be used to identify and characterize plasma cells. It discus...
NUT-rearranged sarcoma [0.03%]
NUT易位肉瘤
Sintawat Wangsiricharoen,Jeanne M Meis,Wendong Yu
Sintawat Wangsiricharoen
NUT-rearranged sarcoma is an emerging group of soft tissue sarcomas defined by NUT rearrangement. It is distinct from NUT carcinoma. These sarcomas show a predilection for somatic soft tissue, the thoracic region, the gastrointestinal tract...
Keratocystoma: Molecular insights and diagnostic challenges in a rare salivary gland tumor [0.03%]
keratocyst瘤：罕见唾液腺肿瘤的分子见解和诊断挑战
Yoshitaka Utsumi,Masato Nakaguro,Justin A Bishop et al.
Yoshitaka Utsumi et al.
Keratosytoma is a rare, benign salivary gland tumor designated as a new entity by Nagao et al. in 2002. Recently, the discovery of RUNX2 gene rearrangement as a characteristic genetic alteration has established its classification as a disti...
Carina A Dehner,John S A Chrisinger
Carina A Dehner
John S A Chrisinger,Carina A Dehner
John S A Chrisinger
Keratin-positive giant cell-rich tumor is a recently described mesenchymal neoplasm, which occurs predominantly in young women and often arises in the subcutis or bone. Histologically, tumors vary from giant cell tumor-like to xanthogranulo...
Ingrid Ferreira,Thomas Brenn
Ingrid Ferreira
The diagnosis of melanoma remains challenging due to its wide clinical, histopathologic and molecular spectrum. While melanomas typically display a melanocytic phenotype by immunohistochemistry, staining for the conventional markers of mela...
Role of the bone marrow microenvironment in multiple myeloma: Impact of niches on drug resistance mechanisms [0.03%]
骨髓微环境在多发性骨髓瘤中的作用：生态位对耐药机制的影响
Lijie Wang,Mingyue Shi,Andrew Y Sung et al.
Lijie Wang et al.
Multiple myeloma (MM) is a blood cancer characterized by the uncontrolled growth of plasma cells in the bone marrow. These malignant plasma cells can proliferate locally and spread to other tissues and organs. The M-protein they produce can...
Cytogenetic and molecular aberrations at diagnosis and in prognosis of multiple myeloma [0.03%]
多发性骨髓瘤诊断和预后中的细胞遗传学和分子异常
Beenu Thakral,Anjanaa Vijayanarayanan,L Jeffrey Medeiros et al.
Beenu Thakral et al.
Multiple myeloma accounts for ∼10 % of all hematologic malignancies. It is genetically a highly heterogeneous disease. Cytogenetic aberrations can be found in only one-third of myeloma cases by karyotyping, in contrast to >90 % by interpha...