Histopathological and genetic landscape of pancreatic ductal adenocarcinoma and its variants [0.03%]
胰腺导管腺癌及其变异体的组织病理学和遗传特征
Nicholas J Caldwell,M Lisa Zhang
Nicholas J Caldwell
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease where proper pathologic evaluation ensures appropriate clinical management. This review article summarizes literature regarding problematic, uncommon, and new challenges in PD...
Extrahepatic cholangiocarcinoma: Current concepts in histopathology, immunohistochemistry, and molecular diagnostics [0.03%]
肝外胆管癌：组织病理学、免疫组织化学和分子诊断的当前概念
Jared Beyersdorf,M Lisa Zhang
Jared Beyersdorf
Cholangiocarcinoma (CCA) makes up a diverse group of malignancies that originate from the biliary epithelium. Despite its rarity, this is a highly aggressive group of diseases with a high mortality, which has been increasing on a global sca...
Miguel Dario Cantu,Weina Chen
Miguel Dario Cantu
Distinguishing multiple myeloma from B-cell lymphomas can be a diagnostic challenge. There can be significant morphologic, immunophenotypic and clinical overlap that may require additional molecular genetic ancillary studies and careful cli...
NCOA1/2/3-rearranged low-grade fibroblastic/myofibroblastic spindle cell tumors: including emerging entities beyond the WHO 5th edition of Bone and Soft Tissue Tumors - a systematic review [0.03%]
NCOA1/2/3重排的低级别成纤维细胞/肌成纤维细胞梭形细胞肿瘤：包括超越WHO第五届骨和软组织肿瘤版的新兴实体-系统性综述
Rayan Sibira,Josephine K Dermawan
Rayan Sibira
Abbas Agaimy
Abbas Agaimy
The increasing use of next generation sequencing (NGS) technologies has resulted in a rapid increase in molecularly defined mesenchymal entities and enabled molecular characterization of existing phenotypically defined entities. These recen...
Pancreatic neuroendocrine neoplasms: current paradigms and diagnostic challenges [0.03%]
胰腺神经内分泌肿瘤：当前诊治模式与诊断挑战
Grace J Kwon,Chanjuan Shi
Grace J Kwon
Pancreatic neuroendocrine neoplasms (PanNENs) are broadly divided into well-differentiated pancreatic neuroendocrine tumors (PanNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs). Grading is based on the mitotic ...
Head and neck xanthogranulomatous epithelial tumors/keratin-positive giant cell-rich tumors [0.03%]
头颈部类上皮黄色肉芽肿样肿瘤/角蛋白阳性巨细胞丰富型肿瘤
Rumeal D Whaley
Rumeal D Whaley
Xanthogranulomatous epithelial tumor (XGET) and keratin-positive giant cell-rich tumor (KPGCT) represent ends along the spectrum of a single neoplastic entity, with overlapping clinical, morphologic, immunohistochemical, and genetic finding...
Adam C Seegmiller
Adam C Seegmiller
Multiparameter flow cytometry is an effective tool in the diagnosis and monitoring of plasma cell neoplasms such as multiple myeloma. This review focuses on how flow cytometry can be used to identify and characterize plasma cells. It discus...
NUT-rearranged sarcoma [0.03%]
NUT易位肉瘤
Sintawat Wangsiricharoen,Jeanne M Meis,Wendong Yu
Sintawat Wangsiricharoen
NUT-rearranged sarcoma is an emerging group of soft tissue sarcomas defined by NUT rearrangement. It is distinct from NUT carcinoma. These sarcomas show a predilection for somatic soft tissue, the thoracic region, the gastrointestinal tract...
Keratocystoma: Molecular insights and diagnostic challenges in a rare salivary gland tumor [0.03%]
keratocyst瘤：罕见唾液腺肿瘤的分子见解和诊断挑战
Yoshitaka Utsumi,Masato Nakaguro,Justin A Bishop et al.
Yoshitaka Utsumi et al.
Keratosytoma is a rare, benign salivary gland tumor designated as a new entity by Nagao et al. in 2002. Recently, the discovery of RUNX2 gene rearrangement as a characteristic genetic alteration has established its classification as a disti...