Synthesis of Glycosylphosphatidylinositol Analogues with an Unnatural β-D-Glucosamine-(1→6)- myo-Inositol Motif [0.03%]
具有 unnatural β-D-葡糖胺-(1→6)-肌醇结构单元的 GPI 模拟物的合成
Xin Yan,Zhongwu Guo
Xin Yan
Glycosylphosphatidylinositol (GPI) anchors contain a unique α-D-glucosamine-(1→6)-myo-inositol [αGlcN(1,6)Ins] motif in their conserved core structure. To facilitate investigations of the functional roles of this structural motif, two GP...
Syntheses of Propargyl Glycosides of Disaccharides of the Capsular Polysaccharides from Serotypes 4, 7F, and 9V Streptococcus pneumoniae Useful for Glycoconjugate Vaccines [0.03%]
用于糖缀合疫苗的肺炎链球菌4、7F和9V血清型荚膜多糖双糖 propargyl 糖苷的合成
Seth A Taylor,Kendell White,Regan Patton et al.
Seth A Taylor et al.
We have developed a means of presenting relatively small glycans in a context to make them T cell-dependent antigens. This approach requires synthesis of glycans that remain close to carrier proteins upon conjugation, allowing T cell recogn...
Zhongwu Guo
Zhongwu Guo
Glycosphingolipids (GSLs) are a subclass of glycolipids made of a glycan and a ceramide that, in turn, is composed of a sphingoid base moiety and a fatty acyl group. GSLs represent the vast majority of glycolipids in eukaryotes, and as an e...
Design and synthesis of 4-azido-phosphatidylinositol as a potential probe for metabolic engineering of glycosylphosphatidylinositol on cells [0.03%]
作为细胞中糖基磷脂酰肌醇代谢工程潜在探针的4-叠氮基磷酸肌醇的设计与合成
Kendall C Craig,Zhongwu Guo
Kendall C Craig
A diacyl phosphatidylinositol (PI) derivative with an azide linked to its inositol C4-position was effectively synthesized in 19 steps for the longest linear sequence and in a ca. 1% overall yield from 1,2-distearoyl-sn-glycerol and D-gluco...
Qian Qin,Shuyao Lang,Xuefei Huang
Qian Qin
As typical affinities of carbohydrates with their receptors are modest, polymers of carbohydrates (glycopolymers) are exciting tools to probe the multifaceted biological activities of glycans. In this review, the linear glycopolymers and th...
Peptide Mapping and Glycoanalysis of Cancer Cell-Expressed Glycoproteins CA215 Recognized by RP215 Monoclonal Antibody [0.03%]
RP215单克隆抗体识别的癌细胞表达糖蛋白CA215的肽图分析和糖基化分析
Gregory Lee,Parastoo Azadi
Gregory Lee
RP215 monoclonal antibody was shown to react with carbohydrate-associated epitope(s) in cancer cell-expressed glycoproteins known as CA215 based on indirect experimental evidences. Efforts have been made to identify glycans in CA215 that ma...
Synthesis of glycoimmunogen Tn-Thr-PS A1 via hydrazone bond and stability optimization of PS A1 monosaccharide mimics under vaccine development conditions [0.03%]
用于疫苗开发的Tn-Thr-PS A1的合成及其单糖模拟物在疫苗开发条件下的稳定性优化
F Hossain,S Nishat,S Ghosh et al.
F Hossain et al.
Previously, our group constructed several immunogens utilizing oxime linkage to conjugate a T-cell stimulatory zwitterionic polysaccharide PS A1 and tumor associated carbohydrate antigens (TACAs) in acetate buffer. Here, a semi-synthetic im...
Facile Synthesis of Sugar Lactols via Bromine-Mediated Oxidation of Thioglycosides [0.03%]
通过溴介导的硫苷类化合物氧化简便合成糖醇酯类化合物
Shuai Meng,Bishwa Raj Bhetuwal,Padam P Acharya et al.
Shuai Meng et al.
Synthesis of a variety of sugar lactols (hemiacetals) has been accomplished in moderate to excellent yields by using bromine-mediated oxidation of thioglycosides. It was found that acetonitrile is the optimal solvent for this oxidation reac...
Facile Synthesis of Sugar Lactols via Bromine-Mediated Oxidation of Thioglycosides [0.03%]
通过溴介导的氧化噻糖苷简便合成糖乳醇
Shuai Meng,Bishwa Raj Bhetuwal,Padam P Acharya et al.
Shuai Meng et al.
Synthesis of a variety of sugar lactols (hemiacetals) has been accomplished in moderate to excellent yields by using bromine-mediated oxidation of thioglycosides. It was found that acetonitrile is the optimal solvent for this oxidation reac...
A facile synthesis of a complex type N-glycan thiazoline as an effective inhibitor against the antibody-deactivating endo-β-N-acetylglucosaminidases [0.03%]
一种复杂类型的N连接聚糖噻唑啉的简易合成方法，可作为针对抗体失活的内切-β-N-乙酰氨基葡萄糖酶的有效抑制剂
Chao Li,Shilei Zhu,Xin Tong et al.
Chao Li et al.
Endo-β-N-acetylglucosaminidases are a class of endoglycosidases that deglycosylate N-glycans from glycoproteins. We describe here a facile synthesis of a complex type N-glycan thiazoline as a new mechanism-based inhibitor for this class of...