Bizarre astrocytes with cytoplasmic/intranuclear inclusions in an individual with alternating hemiplegia, migraine, and brain swelling associated with a GGC repeat expansion in NOTCH2NLC [0.03%]
NOTCH2NLC区GGC重复扩增致一侧半身瘫痪交替发作、偏头痛和脑肿胀患者的奇异星形胶质细胞含细胞质/核内包涵体
Kaoru Yagita,Kyoko Kanazawa,Terunori Sano et al.
Kaoru Yagita et al.
The aberrant GGC repeat expansion in the 5'-untranslated region of the NOTCH2NLC gene causes neuronal intranuclear inclusion disease (NIID), a progressive neurodegenerative disorder. The clinical features of NIID are highly variable and inc...
Brain tumor microenvironment: Mechanisms, interactions, and therapeutic opportunities [0.03%]
脑肿瘤微环境：机制、相互作用及治疗机会
Adil Aziz Khan,Annmy Jose,Sana Ahuja et al.
Adil Aziz Khan et al.
Brain tumors, including primary gliomas and metastatic brain cancers, create a complex and dynamic tumor microenvironment (TME) that significantly influences tumor progression, therapy resistance, and patient outcomes. This review explores ...
Rare encounter of spinal atypical teratoid/rhabdoid tumor in an adult: A case report and review of clinicopathological diagnostic pitfalls [0.03%]
成人罕见脊髓非典型畸胎样/横纹肌样瘤一例及相关临床病理诊断陷阱复习
Naveen Kumar R,Alexandra Kristin Mawlong,Tamajyoti Ghosh et al.
Naveen Kumar R et al.
Atypical teratoid/rhabdoid tumor (AT/RT) is a highly aggressive embryonal tumor that most commonly affects young children, with primary spinal involvement being exceedingly rare in adults. We highlight a rare case of a 26-year-old female wh...
Christian Mawrin
Christian Mawrin
Toxoplasmic ventriculitis with obstructive hydrocephalus in patient with AIDS: Case report with review of literature [0.03%]
艾滋病患者伴发弓形体脑室炎和阻塞性脑积水的病例报告及文献复习
Rangasamy Thiruvengadam Rajeswarie,Valakunja Harikrishna Ganaraj,Manjunath Netravathi et al.
Rangasamy Thiruvengadam Rajeswarie et al.
Toxoplasmosis is a common opportunistic infection in immunocompromised patients. Cerebral toxoplasmosis can be the initial manifestation of acquired immunodeficiency syndrome (AIDS). We report a case diagnosed at autopsy as the primary pres...
Spreading pattern of phosphorylated tau-positive granular glial pathology in the cerebral white matter of patients with multiple system atrophy [0.03%]
多系统萎缩患者脑白质磷酸化tau阳性颗粒性胶质病理性改变的分布模式
Taku Homma,Yoko Mochizuki,Shinsuke Tobisawa et al.
Taku Homma et al.
Multiple system atrophy (MSA) is a major neurodegenerative disorder characterized by phosphorylated α-synuclein-positive oligodendroglial cytoplasmic inclusions. The presence of phosphorylated τ-positive granular glia (pTGrG) in the cereb...
Bette K Kleinschmidt-DeMasters
Bette K Kleinschmidt-DeMasters
Background: Surgical pathology specimens from patients with hypertrophic pachymeningitis are infrequently encountered. After excluding infectious and neoplastic causes, autoimmune conditions should be considered, especial...
Influence of clinical and histological criteria on meningioma recurrence: The decisive role of Ki-67 [0.03%]
增生性与非增生性脑膜瘤的复发率不同及相关影响因素分析
Henri Salle,Stéphanie Durand,Mathilde Duchesne et al.
Henri Salle et al.
Objective: The risk of meningioma recurrence depends mainly on the extent of resection and tumor grade. In a series of 196 meningiomas, we investigated the influence of clinical and histopathological criteria and sought t...
Christian Mawrin
Christian Mawrin
ALK-positive histiocytosis with isolated central nervous system involvement: Report of two cases and review of a newly described entity [0.03%]
以孤立性中枢神经系统受累为主的携带间变淋巴瘤激酶重排的组织细胞增生症：两例报道和文献复习
Amudhakumar Janani,Sathyakumar Rima,Elumalai Hemnath et al.
Amudhakumar Janani et al.
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a novel and rare entity commonly described as a systemic disease affecting infants, while isolated systemic involvement including the central nervous system (CNS) have been reported...