Clinicopathologic mismatch in young-onset parkinsonism: Multiple system atrophy masquerading as a neurotransmitter synthesis disorder [0.03%]
青年期发病帕金森综合征的临床病理不匹配：一种伪装成神经递质合成障碍的多系统萎缩病例报告
John Michael Newman,Jin Kyung Kim,Jeff Nirschl et al.
John Michael Newman et al.
Background: Multiple system atrophy (MSA) is a progressive adult-onset synucleinopathy that remains difficult to diagnose clinically, particularly in younger patients and during early disease stages. Brainstem nuclei dege...
Clinicopathologic mismatch in young-onset parkinsonism: Multiple system atrophy masquerading as a neurotransmitter synthesis disorder [0.03%]
年轻发病帕金森综合征的临床病理不匹配：多系统萎缩伪装成神经递质合成障碍
John Michael Newman,Jin Kyung Kim,Jeff Nirschl et al.
John Michael Newman et al.
Background: Multiple system atrophy (MSA) is a progressive adult-onset synucleinopathy that remains difficult to diagnose clinically, particularly in younger patients and during early disease stages. Brainstem nuclei dege...
Medial accessory olivary nucleus asymmetry and its selective degeneration in Parkinson's disease: A human neuropathological study [0.03%]
人类神经病理学研究揭示帕金森病中的中橄榄核不对称及其选择性退行性病变
Tahreem Fatima,Shahzad Shams
Tahreem Fatima
Objective: The medial accessory olivary nucleus (MAO), a distinct but inconsistently present subnucleus of the human inferior olivary complex, is poorly characterized despite its proposed role in cerebellar motor circuitr...
Human bornavirus encephalitis: Neuropathological insights from a rare but lethal disease [0.03%]
人博卡病毒性脑炎：一种罕见但致命疾病的神经病理学见解
Nicola Jungbäck,Przemyslaw Grochowski,Patrick Adam et al.
Nicola Jungbäck et al.
Aims: This work aims at supporting structured neuropathological assessment and early case identification for human bornavirus encephalitis. It summarizes current neuropathological and immunopathogenic findings of infectio...
Human West Nile virus lineage 2 neuroinvasive infection as a cause of fatal Guillain-Barré syndrome [0.03%]
人感染西尼罗病毒2型导致的吉兰-巴雷综合征致命病例
Antonio Mastroianni,Sonia Greco,Concetta Castilletti
Antonio Mastroianni
Background: West Nile virus (WNV) is now endemic in Europe and continues to spread to several countries, with strains 1 and 2 primarily responsible for outbreaks. According to the European Centre for Disease Prevention an...
Postmortem cerebellar and brainstem alterations in episodic ataxia type 1 and 2: Expanding the clinicopathological spectrum [0.03%]
遗传性阵发性共济失调1型和2型死后小脑和脑干改变：扩大临床病理学谱系
Jeroen J de Vries,Maria João da Costa Caiado,Wilfred F A den Dunnen
Jeroen J de Vries
Background: Episodic ataxias (EAs) are rare autosomal-dominant channelopathies presenting with recurrent attacks of ataxia and variable neurological features. While MRI studies suggest mild cerebellar atrophy in some pati...
From genes to neuropathology: Integrative perspectives on the spectrum of spinocerebellar ataxias [0.03%]
从基因到神经病理学：脊髓小脑共济失调谱系的综合视角
Jeroen J de Vries,Maria João da Costa Caiado,Wilfred F A den Dunnen
Jeroen J de Vries
This review describes the clinically and genetically heterogenous group of 52 Spinocerebellar ataxias (SCAs). After a brief description of the epidemiology and clinical spectrum, this review highlights the functional neuroanatomy, the need ...
Progressive multifocal leukoencephalopathy as the first presentation of an underlying lymphoproliferative disorder [0.03%]
淋巴增生性疾病的最初表现为进行性多灶性白质脑病
Jennifer Garry,Sophie Sabherwal,Seamus Looby et al.
Jennifer Garry et al.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease caused by John Cunningham virus (JCV) reactivation in immunosuppressed patients. Although classically associated with advanced HIV infection,...
Rapid polymer-based immunohistochemistry for intraoperative CNS tumor diagnosis: A validation study [0.03%]
基于聚合物的快速免疫组化技术在脑神经肿瘤术中诊断中的应用价值研究
Julia Schuler,Sandra Baur,Federico Fusco et al.
Julia Schuler et al.
Intraoperative diagnostics in neuro-oncology face a critical gap between the morphological limitations of hematoxylin-eosin staining or toluidine blue staining and the time-intensive nature of conventional immunohistochemistry (IHC). This d...
Christian Mawrin
Christian Mawrin