The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers [0.03%]
慢缩骨骼肌纤维中的抗坏血酸钠共转运蛋白SVCT2定位于M线水平的板层膜富集区
Daniel Sandoval,Jessica Mella,Jorge Ojeda et al.
Daniel Sandoval et al.
Background: Vitamin C plays key roles in cellular homeostasis, functioning as a potent antioxidant and a positive regulator of cell differentiation. In skeletal muscle, the vitamin C/sodium co-transporter SVCT2 is prefere...
GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions [0.03%]
GLUT1和前肾素受体介导高糖条件下肾髓质集合管细胞TGF-β和CTGF的差异调节
Paulina E Larenas,Pilar Cárdenas,Monserrat Aguirre-Delgadillo et al.
Paulina E Larenas et al.
Background: During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor (PRR) on the apical plasma membrane triggers intracellular profibrotic genes, includin...
Advances in genomic tools for plant breeding: harnessing DNA molecular markers, genomic selection, and genome editing [0.03%]
植物育种的基因组工具研究进展：开发和利用DNA分子标记、全基因选择以及基因组编辑技术
Rahul Kumar,Sankar Prasad Das,Burhan Uddin Choudhury et al.
Rahul Kumar et al.
Conventional pre-genomics breeding methodologies have significantly improved crop yields since the mid-twentieth century. Genomics provides breeders with advanced tools for whole-genome study, enabling a direct genotype-phenotype analysis. ...
Increasing carotenoid production in Xanthophyllomyces dendrorhous/Phaffia rhodozyma: SREBP pathway activation and promoter engineering [0.03%]
提高红霉负球子酶生产类胡萝卜素水平：SREBP 途径激活与启动子工程
Alejandro Durán,Maximiliano Venegas,Salvador Barahona et al.
Alejandro Durán et al.
The yeast Xanthophyllomyces dendrorhous synthesizes astaxanthin, a high-value carotenoid with biotechnological relevance in the nutraceutical and aquaculture industries. However, enhancing carotenoid production through strain engineering re...
DLK1 and DLK2, two non-canonical ligands of NOTCH receptors, differentially modulate the osteogenic differentiation of mesenchymal C3H10T1/2 cells [0.03%]
DLK1和DLK2通过非经典NOTCH信号通路不同地调节成脂前体细胞的成骨分化的作用及机制研究
María-Milagros Rodríguez-Cano,María-Julia González-Gómez,Eva-María Monsalve et al.
María-Milagros Rodríguez-Cano et al.
Background: C3H10T1/2 is a mesenchymal cell line capable of differentiating into osteoblasts, adipocytes and chondrocytes. The differentiation of these cells into osteoblasts is modulated by various transcription factors,...
Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development [0.03%]
家畜卵泡发育关键时期的卵泡细胞景观转录组分析
Henry David Mogollón García,Rodrigo de Andrade Ferrazza,Julian Camilo Ochoa et al.
Henry David Mogollón García et al.
Background: There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particularly regarding follicular deviation, acquisition of ovulatory capacity, and preovulatory...
Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years [0.03%]
利用蛋白质组学和机器学习整合方法区分15年以上人类骨骼残余物的初步研究
Camila Garcés-Parra,Pablo Saldivia,Mauricio Hernández et al.
Camila Garcés-Parra et al.
Background: Determining the postmortem interval (PMI) accurately remains a significant challenge in forensic sciences, especially for intervals greater than 5 years (late PMI). Traditional methods often fail due to the ex...
Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells [0.03%]
肺肿瘤细胞中内皮素转换酶-1c通过增强顺铂耐药性和恶性表型促进肺癌恶化
Cristopher Almarza,Karla Villalobos-Nova,María A Toro et al.
Cristopher Almarza et al.
Background: Lung cancer constitutes the leading cause of cancer mortality. High levels of endothelin-1 (ET-1), its cognate receptor ETAR and its activating enzyme, the endothelin-converting enzyme-1 (ECE-1), have been rep...
Oviduct epithelial spheroids during in vitro culture of bovine embryos mitigate oxidative stress, improve blastocyst quality and change the embryonic transcriptome [0.03%]
体外培养牛胚胎期间输卵管上皮球体减轻氧化应激、改善囊胚质量和改变胚胎转录组
Thanya Pranomphon,Álvaro López-Valiñas,Carmen Almiñana et al.
Thanya Pranomphon et al.
Background: In vitro embryo production is increasingly used for genetic improvement in cattle but bypasses the oviduct environment and exposes the embryos to oxidative stress with deleterious effects on further developmen...
H Antigen expression modulates epidermal Keratinocyte Integrity and differentiation [0.03%]
H 抗原的表达调控表皮角质形成细胞完整性和分化
Seon-Pil Jin,Jang-Hee Oh,Namjoo Kaylee Kim et al.
Seon-Pil Jin et al.
Background: ABO blood group antigens (ABH antigens) are carbohydrate chains glycosylated on epithelial and red blood cells. Recent findings suggest reduced ABH expression in psoriasis and atopic dermatitis, a chronic infl...