Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling [0.03%]
糖尿病前期大鼠血管功能障碍的性别差异及亚硫酸盐和硫化物信号的作用机制
Sona Cacanyiova,Andrea Berenyiova,Hana Malinska et al.
Sona Cacanyiova et al.
Background: The activity of perivascular adipose tissue (PVAT), a specific deposit of adipose tissue surrounding blood vessels, could contribute to sex differences in vascular tone control, particularly in dyslipidemic di...
Study on the therapeutic potential of induced neural stem cells for Alzheimer's disease in mice [0.03%]
小鼠诱导神经干细胞治疗阿尔茨海默病的潜力研究
Qiongqiong Ji,Yuanhao Lv,Bei Hu et al.
Qiongqiong Ji et al.
Induced neural stem cells (iNSCs), which have similar properties to neural stem cells and are able to self-proliferate and differentiate into neural cell lineages, are expected to be potential cells for the treatment of neurodegeneration di...
Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ [0.03%]
RHBDF1介导的PKCζ核转位扰乱乳腺上皮细胞极性
Huan-Yu Zhao,Yi-Pan Zhu,Ying Wen et al.
Huan-Yu Zhao et al.
Background: The establishment of apicobasal polarity in epithelial cells is of critical importance in morphogenesis of mammary gland and other secretive gland tissues. The demise of the polarity is a critical step in earl...
Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats [0.03%]
慢性外源性缩宫素在低氧条件下对大鼠运动能力及心迷走神经功能的影响
Camila Salazar-Ardiles,Carlos Cornejo,Cristobal Paz et al.
Camila Salazar-Ardiles et al.
Background: Outstanding exercise performance has been associated with an exacerbated vagal outflow. Nevertheless, during high-altitude hypobaric-hypoxia (HH), there is a baroreflex-dependent parasympathetic withdrawal and...
Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration [0.03%]
甲基甘油诱发的行为抑郁症和记忆力丧失与色氨酸耗尽及氧化应激有关：一种新的神经退行性病变体内模型
Md Samsuzzaman,Seong-Min Hong,Jae Hyuk Lee et al.
Md Samsuzzaman et al.
Background: Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing t...
Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model [0.03%]
自噬增强子PACER/RUBCNL在神经元中的过表达会加速SOD1G93A渐冻鼠模型的疾病进展
Luis Labrador,Leonardo Rodriguez,Sebastián Beltran et al.
Luis Labrador et al.
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to familial ALS, with the accumulation o...
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12 [0.03%]
叶酸过量和维生素B12缺乏的饮食操纵通过组蛋白3赖氨酸4三甲基化影响DLK1和GRB10基因进而影响妊娠结局
Divika Sapehia,Aatish Mahajan,Parampal Singh et al.
Divika Sapehia et al.
The aberrant expression of placental imprinted genes due to epigenetic alterations during pregnancy can impact fetal development. We investigated the impact of dietary modification of low vitamin B12 with varying doses of folic acid on the ...
Impact of salmon farming in the antibiotic resistance and structure of marine bacterial communities from surface seawater of a northern Patagonian area of Chile [0.03%]
智利北部巴塔哥尼亚地区海水表面细菌群落的抗生素抗性及大西洋鲑养殖的影响
Javiera Ortiz-Severín,Christian Hodar,Camila Stuardo et al.
Javiera Ortiz-Severín et al.
Background: Aquaculture and salmon farming can cause environmental problems due to the pollution of the surrounding waters with nutrients, solid wastes and chemicals, such as antibiotics, which are used for disease contro...
Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains [0.03%]
一个新的酵母图谱群体表型研究揭示了野生菌株和家养菌株活化TORC1信号通路的差异
Guilherme Rocha,Melissa Gómez,Camila Baeza et al.
Guilherme Rocha et al.
Domestication can be understood as a symbiotic relationship that benefits both domesticator and domesticated species, involving multiple genetic changes that configure the phenotype of the domesticated species. One of the most important dom...
Ting Jiang,Chengxiu Zhang,Xinjing Cao et al.
Ting Jiang et al.
Backgroud: abnormalities or defects in oocyte meiosis can result in decreased oocyte quality, reduced ovarian reserve, and female diseases. However, the mechanisms of oocyte meiosis remain largely unknown, especially epig...