The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii [0.03%]
铜绿假单胞菌中周质蛋白HslJ是一线抗氧化胁迫分子
Daniela Scribano,Martina Pasqua,Dolores Limongi et al.
Daniela Scribano et al.
Background: Acinetobacter baumannii poses a significant threat globally, causing infections primarily in healthcare settings, with high mortality rates. Its adaptability to antibiotic resistance and tolerance to various s...
A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development [0.03%]
一种新的CUL4B基因变异通过激活Wnt4/β-catenin信号通路导致染色体为46,XY的女性性发育异常患者的研究
Chunlin Wang,Hong Chen,Qingqing Chen et al.
Chunlin Wang et al.
Background: Karyotype 46, XY female disorders of sex development (46, XY female DSD) are congenital conditions due to irregular gonadal development or androgen synthesis or function issues. Genes significantly influence D...
Case Reports
Biological research. 2025 Jan 7;58(1):1. DOI:10.1186/s40659-024-00583-1 2025
Regional Hereditary Cancer Program in Chile: A scalable model of genetic counseling and molecular diagnosis to improve clinical outcomes for patients with hereditary cancer across Latin America [0.03%]
智利区域遗传性癌症计划：一种可扩展的遗传咨询和分子诊断模式，可改善拉丁美洲遗传性癌症患者的临床预后
Natalia Landeros,Laura Vargas-Roig,Silvina Denita et al.
Natalia Landeros et al.
Background: Breast cancer is a leading cause of cancer-related mortality worldwide, with hereditary forms accounting for approximately 10% of cases. In Chile, significant gaps exist in genetic counseling and testing, part...
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development [0.03%]
智利癌症现状（二）：研究、战略及分析框架的更新以实现公平性、创新和国家发展
Cristóbal Vacarezza,Julieta Araneda,Pamela Gonzalez et al.
Cristóbal Vacarezza et al.
Introduction: Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago...
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion [0.03%]
NOX蛋白和ROS生成：在侵袭突质形成及肿瘤细胞转移中的作用
Nelson Quilaqueo-Millaqueo,David A Brown-Brown,Jetzabel A Vidal-Vidal et al.
Nelson Quilaqueo-Millaqueo et al.
NADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at the cellular surface. In cancer, these highly reactive molecules primarily originate in mitochondria and via NOX, play...
Are we cultivating the perfect storm for a human avian influenza pandemic? [0.03%]
人畜共患流感大流行病毒的培育计划？
Tomas Perez-Acle,Cesar Ravello,Mario Rosemblatt
Tomas Perez-Acle
The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter in the ongoing battle against zoonotic diseases. Since its initial detection in 1955, the H5N1 virus has primarily been ass...
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells [0.03%]
连接蛋白在高度恶性的前列腺癌细胞中活性缺失
Catalina Asencio,Loreto Véliz,Emilia Flores-Faúndez et al.
Catalina Asencio et al.
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra- and extra-cellular compartments (hemichannels, HC). Cxs were initially c...
A single-base deletion in exon 2 of Hd1 delineates monogenic recessive photoperiod insensitivity in aromatic Joha rice: a novel allele for seasonal adaptability [0.03%]
水稻Hd1基因外显子2单碱基缺失导致香稻小季早花遗传机制的研究：适应季节变化的新等位基因
Bodeddula Jayasankar Reddy,Shreekant M Baradkar,Tamma V S S Manogna et al.
Bodeddula Jayasankar Reddy et al.
Background: Assam's aromatic Joha rice is a unique rice class famous for its aroma, taste, and nutritional benefits, which fetch high market prices in domestic and international markets. Joha landraces are inherently poor...
Heterogeneity in the formation of primary and secondary visual fields during human prenatal development [0.03%]
人胚前脑发育中视网膜及视皮层的异质性分区机制研究
Olga Godovalova,Alexandra Proshchina,Anastasia Kharlamova et al.
Olga Godovalova et al.
The human neocortex has a huge surface area with unique cytoarchitectonics, most of which is concealed in sulci. Some cytoarchitectonic fields are associated with macroscopic landmarks. In particular, the primary visual field 17 is associat...
Stress drives premature hive exiting behavior that leads to death in young honey bee (Apis mellifera) workers [0.03%]
压力促使年轻的意大利蜜蜂（Apis mellifera）提早出巢而导致其死亡
Jordan Twombly Ellis,Juliana Rangel
Jordan Twombly Ellis
Background: The Western honey bee, Apis mellifera, is an economically important pollinator, as well as a tractable species for studying the behavioral intricacies of eusociality. Honey bees are currently being challenged ...