Endocannabinoid system upregulates the enrichment and differentiation of human iPSC- derived spermatogonial stem cells via CB2R agonism [0.03%]
内源性大麻素系统通过CB2R激动作用上调人iPSC衍生的精原干细胞的富集和分化
Merve Gizer,Selin Önen,Özgür Doğuş Erol et al.
Merve Gizer et al.
Background: Male factor infertility (MFI) is responsible for 50% of infertility cases and in 15% of the cases sperm is absent due to germ cell aplasia. Human induced pluripotent stem cell (hiPSC)-derived spermatogonial st...
Small extracellular vesicles enhance the survival of Sca-1+ cardiac stem cells against ROS-induced ischemic-reoxygenation injury in vitro [0.03%]
小型细胞外囊泡提高Sca-1+心脏干细胞对抗ROS诱导的体外缺氧再复氧损伤的存活率
Radwa A Mehanna,Hagar Elkafrawy,Marwa M Essawy et al.
Radwa A Mehanna et al.
Background: Ischemic reperfusion (IR) generates reactive oxygen species (ROS) that inevitably result in myocardial cell death and heart failure. The regenerative power of cardiac progenitor/stem pools (CSCs), especially t...
Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells [0.03%]
血清素以细胞类型特异性方式调节小鼠视网膜神经节细胞的光诱发反应和突触活性
Claudia Di Berardino,Sebastián F Estay,Alejandro Alcaino et al.
Claudia Di Berardino et al.
Background: Serotonin (5-HT) is known to be synthesized and accumulated in the vertebrate retina through the 5-HT transporter, SERT. While manipulation of the serotonergic system has been shown to impact visual processing...
Calcium electroporation induces stress response through upregulation of HSP27, HSP70, aspartate β-hydroxylase, and CD133 in human colon cancer cells [0.03%]
钙电穿孔通过上调人结肠癌细胞中HSP27，HSP70，天冬氨酸β-羟化酶和CD133诱导应激反应
Anna Szewczyk,Nina Rembiałkowska,Jolanta Saczko et al.
Anna Szewczyk et al.
Background: Electroporation (EP) leverages electric pulses to permeabilize cell membranes, enabling the delivery of therapeutic agents like calcium in cancer treatment. Calcium electroporation (CaEP) induces a rapid influ...
Correction: The periplasmic protein HslJ is the firstline of defense against oxidative stress in Acinetobacter baumannii [0.03%]
订正：HslJ是阿氏菌对抗氧化应激的一线防御蛋白
Daniela Scribano,Martina Pasqua,Dolores Limongi et al.
Daniela Scribano et al.
Published Erratum
Biological research. 2025 Jan 30;58(1):9. DOI:10.1186/s40659-025-00588-4 2025
hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling [0.03%]
人脐带间充质干细胞通过SIRT1/PGC-1α/TFAM信号通路修复海绵体神经损伤大鼠阴茎平滑肌细胞线粒体质量以维持勃起功能
Mengbo Yang,Xinda Chen,Ming Zhang et al.
Mengbo Yang et al.
Background: Cavernous nerve injury-induced erectile dysfunction (CNI-ED) is a common complication following radical prostatectomy and severely affects patients' quality of life. The mitochondrial impairment in corpus cave...
Fluoride-induced testicular and ovarian toxicity: evidence from animal studies [0.03%]
动物研究证据表明氟导致睾丸和卵巢毒性
Seyedeh Fahimeh Talebi,Mohammad Seify,Ramji Kumar Bhandari et al.
Seyedeh Fahimeh Talebi et al.
Fluoride (F), as a natural element found in a wide range of sources such as water and certain foods, has been proven to be beneficial in preventing dental caries, but concerns have been raised regarding its potential deleterious effects on ...
Exposure of Apis mellifera (Hymenoptera: Apidae) colonies to imidacloprid impairs larval development, promotes oxidative stress in pupae, and induces changes in the midgut of adult bees [0.03%]
啶虫脒对Apis mellifera(Hymenoptera：Apidae)蜂群的影响会损害幼虫发育，促进蛹氧化应激，并引起成年蜜蜂中肠变化
Daiani Rodrigues Moreira,Tuan Henrique Smielevski de Souza,Douglas Galhardo et al.
Daiani Rodrigues Moreira et al.
Bees are essential pollinators that contribute to maintaining biodiversity and increasing agricultural production. However, by foraging on agricultural crops, bees may become contaminated with compounds used for pest control. In this study,...
Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival [0.03%]
Maraviroc/顺铂联合抑制胃癌肿瘤生长并延长小鼠生存时间
Bárbara Mora-Lagos,María Elena Reyes,Lorena Lobos-Gonzalez et al.
Bárbara Mora-Lagos et al.
Background: Gastric cancer (GC) is a significant cancer-related cause of death worldwide. GC's most used chemotherapeutic regimen is based on platinum drugs such as cisplatin (CDDP). However, CDDP chemoresistance reduces ...
Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species [0.03%]
蛋白质棕榈酰化通过钙信号、蛋白酪氨酸磷酸化和活性氧信号参与调控小鼠精子运动性
Yuping Xiong,Chenchen Yi,Haixia Zheng et al.
Yuping Xiong et al.
Background: Protein palmitoylation, a critical posttranslational modification, plays an indispensable role in various cellular processes, including the regulation of protein stability, mediation of membrane fusion, facili...