Cardiac endothelial cells and cardiomyocytes alter their communication properties in diabetic mice [0.03%]
糖尿病小鼠的心内皮细胞和心肌细胞改变其通讯特性
Yan Wen,Qing Wang
Yan Wen
Objective: We aimed to explore the heterogeneities and communication properties of cardiac CMs and ECs in diabetes. Methods: GSE213337 ...
Palmitoylation in focus: bridging reproductive biology and translational research [0.03%]
棕榈酰化研究专论：生殖生物学与转化医学研究齐头并进
Suriyaraj Shanmugasundaram Prema,Deepankumar Shanmugamprema
Suriyaraj Shanmugasundaram Prema
Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome [0.03%]
脆性X综合征小鼠模型中的嗅觉障碍和皮质兴奋性改变
Felipe Arancibia,Marcelo Rojas,Diego Becerra et al.
Felipe Arancibia et al.
Fragile X Syndrome (FXS) is the most common monogenetic cause of autism and inherited intellectual disability. A key feature of FXS symptomatology is altered sensory processing greatly affecting FXS individual's life quality. Here, we use a...
Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal [0.03%]
伴侣蛋白辅助的E3泛素连接酶修饰间充质干细胞靶向降解高糖诱导的p53蛋白改善自我更新能力
Ayaz Ali,Wei-Wen Kuo,Chia-Hua Kuo et al.
Ayaz Ali et al.
Background: Stem cell therapies may potentially be used in regenerative and reconstructive medicine due to their ability for self-renewal and differentiation. Stressful conditions, such as hyperglycemia, adversely affect ...
Uncovering leading compounds for alzheimer's disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation [0.03%]
阿尔茨海默病治疗的领先化合物发现：针对血浆蛋白调控的孟德尔随机化和虚拟筛选研究见解
Xiaohan Sun,Xiaofei Hu,Jianming Wei et al.
Xiaohan Sun et al.
Alzheimer's disease (AD) is a neurodegenerative disorder influenced by both genetic and environmental factors. Identifying therapeutic targets and interventions remains challenging. This study utilized Mendelian Randomization (MR) to invest...
Functional characterization of two KCND3 variants associated with SCA 19/22 ataxia in Latin American families [0.03%]
与拉丁美洲家族的SCA 19/22 共济失调相关的两个KCND3基因变异的功能表征
Felipe Arancibia,Fernanda Martin,Jenny Ruiz-Fuentes et al.
Felipe Arancibia et al.
Background: Spinocerebellar ataxia 19/22 (SCA19/22) represents a rare autosomal dominant genetic disorder resulting in progressive ataxia and cerebellar atrophy. SCA19/22 is caused by variants in the KCND3 gene, which enc...
Interactive and evolutionary effect of CASZ1 gene variants on varicose veins susceptibility in South Asian Indians [0.03%]
CASZ1基因多态性交互作用及其对南亚印度人静脉曲张易感性的进化效应研究
Rohit Mehra,Vikram Patra,Rishi Dhillan et al.
Rohit Mehra et al.
Background: Varicose veins (VV) are spectrum of common vascular diseases having complex genetic etiology. The Castor Zinc Finger 1 (CASZ1) gene has been involved in vascular development and its variant has shown associati...
Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review [0.03%]
胃癌中PD-L1表达机制的最新进展：一项回顾
Peifeng Chen,Zhangming Chen,Wannian Sui et al.
Peifeng Chen et al.
In the progression of gastric cancer (GC), various cell types in the tumor microenvironment (TME) exhibit upregulated expression of programmed death ligand 1 (PD-L1), leading to impaired T-cell function and evasion of immune surveillance. I...
Investigation of the synergistic effect of metformin and FX11 on PANC-1 cell lines [0.03%]
二甲双胍和FX11对PANC-1细胞系联合作用的研究
Melike Bayindir-Bilgic,Ezgi Duman,Deniz Turgut et al.
Melike Bayindir-Bilgic et al.
Background: Pancreatic cancer is among the most aggressive and malignant tumors and is a leading cause of cancer-related mortality. It is characterized by its metabolic Warburg effect and glucose dependence. Aerobic glyco...
Jordi Ribas-Maynou,Ana Parra,Pablo Martínez-Díaz et al.
Jordi Ribas-Maynou et al.
Background: Oxidative stress, a source of genotoxic damage, is often the underlying mechanism in many functional cell disorders. Extracellular vesicles (EVs) have been shown to be key regulators of cellular processes and ...