Jiahui Li,Xiaolei Liu,Zengze Wang et al.
Jiahui Li et al.
Background: Stroke is a leading cause of death worldwide, with oxidative stress and calcium overload playing significant roles in the pathophysiology of the disease. Ozone, renowned for its potent antioxidant properties, ...
Virginia Ruiz-Martín,Tamara Marcos,José María de Pereda et al.
Virginia Ruiz-Martín et al.
Background: The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and...
Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies [0.03%]
人类穆勒管畸形的CHD1L基因变异体的鉴定及其功能特征
Shuya Chen,Yali Fan,Yujun Sun et al.
Shuya Chen et al.
Background: Müllerian duct anomalies (MDAs) are congenital developmental disorders that present as a series of abnormalities within the reproductive tracts of females. Genetic factors are linked to MDAs and recent advanc...
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus [0.03%]
孕期母体压力会改变循环中的小型细胞外囊泡并增强其向胎盘和胎儿的靶向定位
Mario Sánchez-Rubio,Lorena Abarzúa-Catalán,Ana Del Valle et al.
Mario Sánchez-Rubio et al.
Background: Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenata...
Comparative study of the growth, stress status and reproductive capabilities of four wild-type zebrafish (Danio rerio) lines [0.03%]
四种野生型斑马鱼(Danio rerio)品系的生长、应激状态和繁殖能力的比较研究
Céline Chevalier,Clémence Denis,Sid-Ahmed Nedjar et al.
Céline Chevalier et al.
Background: Zebrafish are widely used in various research fields and to fulfil the diverse research needs, numerous zebrafish lines are available, each with a unique domestication background, potentially resulting in intr...
Comparative Study
Biological research. 2024 Sep 19;57(1):67. DOI:10.1186/s40659-024-00549-3 2024
PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1 [0.03%]
来源于Leydig细胞的PTN通过GFRA1调节人 spermatogonial干细胞增殖和存活
Xueheng Zhao,Lvjun Liu,Zenghui Huang et al.
Xueheng Zhao et al.
Background: Spermatogonial stem cells (SSCs) are essential for the maintenance and initiation of male spermatogenesis. Despite the advances in understanding SSC biology in mouse models, the mechanisms underlying human SSC...
The effect of CGRP and SP and the cell signaling dialogue between sensory neurons and endothelial cells [0.03%]
CGRP和SP的作用及感觉神经元与内皮细胞之间的信号转导对话的效果
Alice Leroux,Micaela Roque,Elina Casas et al.
Alice Leroux et al.
Increasing evidences demonstrate the role of sensory innervation in bone metabolism, remodeling and repair, however neurovascular coupling in bone is rarely studied. Using microfluidic devices as an indirect co-culture model to mimic in vit...
Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb [0.03%]
小鼠睾丸巨噬细胞可独立产生睾酮并受Cebpb调节
Nengliang Duan,Yuanshuai Ran,Huapei Wang et al.
Nengliang Duan et al.
Background: Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, ha...
Fruit sugar hub: gene regulatory network associated with soluble solids content (SSC) in Prunus persica [0.03%]
桃果实糖分遗传调控网络的解析与关键基因挖掘
Gerardo Núñez-Lillo,Victoria Lillo-Carmona,Alonso G Pérez-Donoso et al.
Gerardo Núñez-Lillo et al.
Chilean peach growers have achieved worldwide recognition for their high-quality fruit products. Among the main factors influencing peach fruit quality, sweetness is pivotal for maintaining the market's competitiveness. Numerous studies hav...
Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism [0.03%]
人工智能发现引擎识别的针对淋球菌肽聚糖代谢相关酶的小分子抗菌活性研究
Ravi Kant,Hannah Tilford,Camila S Freitas et al.
Ravi Kant et al.
Background: Neisseria gonorrhoeae (Ng) causes the sexually transmitted disease gonorrhoea. There are no vaccines and infections are treated principally with antibiotics. However, gonococci rapidly develop resistance to ev...