Hua Wei,Jie Zheng,Yi-han Liu et al.
Hua Wei et al.
Four casssane diterpenes were isolated from the ethanol extract of the seeds of Caesalpinia decapetala (Fabaceae), with a combination of various chromatographic approaches, including silica gel, Sephadex LH-20, reverse phase C18 and so on. ...
[Design, synthesis and evaluation of 4-pyridinylthiazole-2-amines as acetylcholinesterase inhibitors] [0.03%]
作为乙酰胆碱酯酶抑制剂的4-吡啶基硫唑-2-胺的设计、合成及评价
Ting-ting Cao,Jun-tao Chen,Chun-liu Yang et al.
Ting-ting Cao et al.
Alzheimer’s disease (AD) is a degenerative disease of the nervous system. Compound I reported to have inhibitory activity on AChE was used as a lead compound in this study, and 4-pyridinylthiazole-2-amines were designed by optimizing compo...
[Effect of Huangqi decoction on entecavir pharmacokinetics in rat plasma] [0.03%]
黄芪汤对恩替卡韦药代动力学影响的实验研究
Yuan-yuan Li,Jia-kai Zeng,Xue-yan Zhang et al.
Yuan-yuan Li et al.
Entecavir (ETV), a guanosine nucleotide antiviral agent with activity against hepatitis B virus (HBV) and Huangqi decoction (HQD) that exerts significant therapeutic effects in liver cirrhosis are used as an effective drug combination in th...
[Effect of Valerian Ligusticum Pill on angiogenesis after injury of cerebral ischemia reperfusion in rats] [0.03%]
补脑八味丸对脑缺血再灌注损伤后新生血管生成的影响
Liang-min Gan,Shou-rong Wei,Ben-xu Xiang et al.
Liang-min Gan et al.
This study was designed to detect the impact of Valerian Ligusticum Pill（VLP） on cerebral ischemia reperfusion injury in rats, and explore the mechanism of angiogenesis. Sixty SD male rats were randomly divided into five groups, including sha...
[Anti-tumor effect and impact on tumor immune microenvironment of tumor-targeted Salmonella VNP20009] [0.03%]
肿瘤靶向沙门氏菌VNP20009的抑瘤效果及其对肿瘤免疫微环境的影响
Yu-heng Han,Xing-huan Lai,Zi-wei Le et al.
Yu-heng Han et al.
Salmonella is a gram-negative bacterium that has an ability of tumor-targeting growth and proliferation. Attenuated Salmonella VNP20009 is a virulence genes-knockout bacterial strain based on Salmonella typhimurium, and it has an advantage ...
[Changes of P-gp expression in rats’ small intestine and effects on uptake of levofloxacin after acute exposure to hypoxia] [0.03%]
缺氧大鼠小肠P-糖蛋白表达变化及对左氧氟沙星吸收的影响
Wen-bin Li,Bing-feng Luo,Rong Wang et al.
Wen-bin Li et al.
The drug transporter play a key role in the absorption of drugs. Investigation of the changes of drug transporters in response to hypoxia will provide insight into the mechanism of drug absorption. In this study we investigated the mRNA and...
[Effect of long-term treatment of Wuzhi tablet on the expression and activity of cytochrome P450 3A in rats] [0.03%]
补肾填精中药五子衍宗丸长期给药对大鼠细胞色素P450 3A表达及活性的影响
Xiao-ling Qin,Wen-hai Duan,Ling-jue Li et al.
Xiao-ling Qin et al.
The study aims to evaluate the effect of long-term pretreatment of the rat with Wuzhi tablet（WZ） on hepatic and intestinal CYP3A mRNA and protein expression and activity. Male Sprague-Dawley rats were orally administered of midazolam (2 mg·k...
[Baicalein prolongs the lifespan of Drosophila melanogaster through antioxidation activity] [0.03%]
黄芩素通过抗氧化活性延长果蝇寿命
Dan-dan Duan,Li Gao,Ke-xin Wang et al.
Dan-dan Duan et al.
In order to explore the anti-aging effect of baicalein, female Drosophila melanogaster as a model organism was used to study the effects of baicalein on natural aging model and aging models induced by hydrogen peroxide（H2O2） and paraquat. The...
[Progress of marine anticancer agents targeting cellular proapoptotic molecules] [0.03%]
海洋抗癌药研究进展：靶向细胞促凋亡分子
Cong Li,Huan-li Xu,Ming Liu et al.
Cong Li et al.
Apoptosis, a form of programmed cell death, is a critical defense mechanism against the formation and progression of cancer. In vivo, apoptosis functions to eliminate potentially deleterious cells without causing such adverse effects as inf...
Fang-fang Li,Dan Zhang,Xiu-qi Bao et al.
Fang-fang Li et al.
Sphingolipids are a class of lipids that have important signaling functions. The most widely studied bioactive shingolipids include ceramides, sphingosine-1-phosphate and so on. In contrast, dihydroceramides have received poor attention. Ho...