[Current status of ion channels as drug targets for diabetic neuropathic pain] [0.03%]
离子通道在糖尿病神经痛药物研发中的作用及其现状
Yu Zhou,Xiao-liang Wang,Hai-bo Yu
Yu Zhou
Diabetic neuropathic pain (DNP) is the most common chronic complication of diabetes mellitus, significantly affecting people’s quality of life. Studies have indicated that ion channels play a very important role in the occurrence of DNP. T...
[Advances in the study of the rat model of aging induced by D-galactose] [0.03%]
[D-半乳糖诱导大鼠衰老模型的研究进展]
Fan-fan Zhao,Yu-zhi Zhou,Li Gao et al.
Fan-fan Zhao et al.
D-galactose (D-gal)-induced aging model is widely used in the study of the pharmacodynamics of antiaging drugs. The model has a shorter life-span, disorders in learning and memory, reduced immune function and other aging characteristics. Re...
[Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke] [0.03%]
[缺血性卒中治疗药物临床前评价进展与挑战]
Ying Feng,Fei Ma,Ting-ting Xu et al.
Ying Feng et al.
Translating of scientific advances into clinical practice is a major challenge in the stroke research field in the past decades. There were many reasons involved: animal models might not accurately capture all aspects of clinical stroke in ...
[Molecular cloning and prokaryotic expression of a type II ribosome inactivating protein from Polyporus umbellatus] [0.03%]
[秀珍菇II型核糖体失活蛋白的分子克隆与原核表达]
Meng-meng Liu,Yong-mei Xing,Shun-xin Guo
Meng-meng Liu
A type Ⅱ ribosome inactivating protein (RIP) gene was cloned from Polyporus umbellatus sclerotia by RT-PCR method. The full open reading frame cDNA sequence of this gene was 873 bp in length and encoded a 290-aa protein with a molecular we...
[The molecular identification of licorice species and the quality evaluation of licorice slices] [0.03%]
甘草类资源的分子鉴定及粉甘草的质量评价
Rui Yang,Wen-dong Li,Yong-sheng Ma et al.
Rui Yang et al.
Licorice is one of the most common herbs in traditional Chinese medicine, and classified as top grade in Shen Nong Ben Cao Jing. There are three different original plants of licorice stipulated in Chinese Pharmacopeia, Glycyrrhiza uralensis...
[GGI as a gene carrier delivering MDR1 siRNA to A549/DDP cells for reversal of multidrug resistance] [0.03%]
作为载体的GGI蛋白将MDR1-siRNA递送入A549/DDP细胞以逆转多药耐药性研究
Zi-rui Wang,Feng Bai,Xiao-ying Zhang et al.
Zi-rui Wang et al.
This study was designed to reverse multidrug resistance of lung cancer cells by downregulating MDR1 genes through RNA interference (RNAi) technology. A novel biodegradable cationic polymer (PEG- b- PLG-g-PEIs, GGI) was synthesized and chara...
[Inhibition of transformation from puerarin monohydrate to puerarin dihydrate by polyvinylpyrrolidones during dissolution] [0.03%]
聚维酮对葛根素一水合物溶解过程中向二水合物转化的抑制作用
Zhao-yi Zhong,Min Wu,Shuai Qian et al.
Zhao-yi Zhong et al.
Puerarin (PUE), an isoflavone with anti-inflammation, anti-oxidation and neuroprotection effects, has been widely applied to the treatment of cardiovascular diseases in clinics in China. In the current study, we reported that the active pha...
[Simultaneous determination of salidroside and tyrosol in Beagle dog plasma using UHPLC-MS/MS after pre-column dansyl chloride derivatization] [0.03%]
高效液相色谱-串联质谱法结合预柱 Dans 酰氯衍生化同时测定狗血浆中山奈素和酪醇的方法学研究
Shuai Chen,Yuan-yuan Xia,Guang-li Wei et al.
Shuai Chen et al.
A pre-column derivatization method combined with UHPLC-MS/MS was developed for the simultaneous determination of salidroside and tyrosol in Beagle dog plasma. After protein precipitation by acetonitrile, the liquid supernatant was treated w...
Si-cheng Liang,Guang-bo Ge,Yang-liu Xia et al.
Si-cheng Liang et al.
Daphnetin is quickly eliminated in rats after dosing, but the mechanism remains unclear. This study was aimed to investigate the in vitro metabolism of daphnetin using rat liver S9 fractions (RLS9). The metabolites formed in RLS9 were ident...
[Investigation of the potentially effective components of Semen Ziziphi Spinosae based on “in vitro to in vivo” translation approach] [0.03%]
基于“从体外到体内”转化研究方法的刺五加种子潜在有效成分考察
Yan Yan,Qiang Li,Chen-hui Du et al.
Yan Yan et al.
The study aims to investigate the effective components of Semen Ziziphi Spinosae (SZR) in nourishing the heart and tranquilizing the mind. A method of ultra high liquid chromatography (UHPLC) coupled with Q Exactive high resolution mass spe...