Qin-pei Deng,Ran An,Tong-ze Xu et al.
Qin-pei Deng et al.
Human chorionic gonadotrophin (hCG), a glycohormone widely used in treatment of infertility, is a heterodimer composed of an alpha- and a beta-subunit. The heterodimer could be dissociated during production and storage with an impact on its...
Yu-lu Li,Hua-nian Dai,Guo-xu Ma et al.
Yu-lu Li et al.
This study was designed to investigate triterpenoids from the roots of Rosa laevigata Michx. The silica gel column chromatography was used to separate the chemical constituents from the roots of Rosa laevigata Michx. HPLC was used to analyz...
Bin-bin Song,Zi-kuo Zhang,Qing-feng Zhu et al.
Bin-bin Song et al.
This study was conducted to design and synthetize highly efficient, specific, non-resistant small MEK inhibitors. Based on active small molecules which have been reported, we studied the action mode with MEK protein using Autodock 4.2, gene...
[Screening of small molecule inhibitors for PLK1 PBD and evaluation of antitumor activities] [0.03%]
[PLK1 PBD的小分子抑制剂筛选及抗肿瘤活性评价]
Yu-huan Jiang,Jing Zhang,Yun-yu Chen et al.
Yu-huan Jiang et al.
With the method of fluorescence polarization (FP), we screened small molecule inhibitors for PLK1 PBD to identify the lead compounds for antitumor drugs. FP led to the identification of a potent hit, F083-0063, whose inhibition rate was (99...
[Transglutaminase-based antibody-drug conjugation: antibody site-specific mutation and identification] [0.03%]
【基于转谷氨酰胺酶的抗体药物偶联物技术：抗体定点突变和位点识别】
Zhao-xiong Ma,Yao Xu,Hong Zhao et al.
Zhao-xiong Ma et al.
Transglutaminase (TG) posttranslational modification of antibody permits more precisely conjugating. Based on the amino acid sequence of an anti-CD24 antibody (cG7), this article is aimed to generate a deglycosylated cG7 mutant (cG7Q). Firs...
[Effect of apigenin on dendritic cells maturation and function in murine splenocytes] [0.03%]
[芹菜素对小鼠脾细胞树突状细胞成熟和功能的影响]
Yi-fei Liu,Xiao-xu Xue,Zheng-yi Li et al.
Yi-fei Liu et al.
This study was designed to explore the effect of apigenin (Api) on dendritic cell (DCs) maturation and function in murine spleen cells. The single spleen cell was isolated, and then cultured with lipopolysaccharide (LPS) in the present and ...
[Protection effects of schizandrin B against liver injury induced by clozapine in mice] [0.03%]
五味子醇B对氯氮平致小鼠肝损伤的保护作用
Hui-yuan Bai,Shan Feng
Hui-yuan Bai
This study was conducted to test the effects of schizandrin B (Sch B) on clozapine (CLZ) induced chronic liver injury in mice and the mechanism of action, and this may provide a new approach for clinical prevention of CLZ-induced side effec...
Ying-ying Wang,Lei-yu Tian,Yan Yang et al.
Ying-ying Wang et al.
The pharmacological activities of natural glycosides are closely related to the polyfunctional sugar moieties. Modification of active natural products by glycosylation can change the stereochemical configuration, improve the solubility, tun...
Wen-jun Chen,Tian-yan Zhou,Wei Lu
Wen-jun Chen
Population pharmacokinetics is an emerging discipline developed from the combination of classical pharmacokinetic compartment model and statistics principles, which has been received more and more attention in recent years. Population pharm...
[Advances in the research of inhibitors of enzymes of bacterial peptidoglycan biosynthesis] [0.03%]
细菌肽聚糖生物合成酶抑制剂研究进展
Fan Liu,Hao-yi Meng,Zheng-yang Sun et al.
Fan Liu et al.
In recent years, owing to the abuse of antibiotics, the widespread of resistant bacterial strains became a serious threat to public health. This status demands development of new antibacterial agents with novel mechanisms of action. The rea...