[Screening of small molecule inhibitors for PLK1 PBD and evaluation of antitumor activities]
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With the method of fluorescence polarization (FP), we screened small molecule inhibitors for PLK1 PBD to identify the lead compounds for antitumor drugs. FP led to the identification of a potent hit, F083-0063, whose inhibition rate was (99.7 ± 0.4) % at 10 ... ...
