[Update on immune and metabolic dysregulation in major depressive disorder and the implications for drug intervention] [0.03%]
[抑郁症免疫和代谢紊乱研究进展及对药物干预的启示]
Xiao Zheng,Guang-ji Wang,Hai-ping Hao
Xiao Zheng
Traditional anti-depressant therapy based on the regulation of monoamine neurotransmitters has shown certain limitations. Recently, accumulating clinical and preclinical studies have reported the tantalizing link between immune dysregulatio...
Lei Zhou,Da-fang Zhong,Xiao-yan Chen
Lei Zhou
The major non-P450 enzymes involved in the oxidative metabolism of drugs are: the flavin- containing monooxygenase (FMO), the monoamine oxidase (MAO), the aldehyde oxidase (AO), the xanthine oxidase (XO), the alcohol dehydrogenase (ADH) and...
[Personalized dosing from perspective of pharmacogenomics of drug metabolizing enzymes and transporters] [0.03%]
药物代谢酶和转运体药动基因组学视角下的个体化给药
Quan Zhou,Lu-shan Yu,Su Zeng
Quan Zhou
Pharmacogenomics is defined as research into the relationship between inherited genetic variations in drug metabolizing enzymes, transporters and targets and individual variations in person’s response to drugs (fate of drug in human body, ...
[Determination of hepatic and small intestinal distribution of lignans of Wuzhi tablet in rats by liquid chromatography tandem mass spectrometry method] [0.03%]
高效液相色谱-质谱法测定五味子 Tablet在大鼠肝和小肠中的分布成分（木脂素类）
Xiao-ling Qin,Wen-hai Duan,Hai-fan Wang et al.
Xiao-ling Qin et al.
This study was aimed to determine the hepatic and small intestinal distribution of active lignans in rats after treated with Wuzhi tablet (WZ, Schisandra sphenanthera extract) by LC-MS/MS method. Male Sprague-Dawley rats were sacrificed at ...
[Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study] [0.03%]
[method for determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic studies]
Dong-xia Cheng,Xiao-jian Dai,Yi-fan Zhang et al.
Dong-xia Cheng et al.
Anaprazole is a proton pump inhibitor clinically used for curing peptic ulcer. A rapid, sensitive and convenient LC-MS/MS method was first established for the determination of anaprazole in human plasma. d(3), (13)C-anaprazole was used as i...
Li Meng,Xiao-ke Zheng,Zhi-guang Zhang et al.
Li Meng et al.
The chemical constituents of the seeds of Lepidium apetalum Willd. were investigated using chromatographic methods, including Diaion HP-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, silica gel chromatography and semi-preparative-HPLC. Three com...
[Synthesis and anti-tumor activity of ciprofloxacin-histone deacetylase inhibitor conjugates] [0.03%]
环丙沙星-组蛋白去乙酰化酶抑制剂共轭物的合成及其抗肿瘤活性研究
Ting Pei,Fang Liu,Ai-ping Deng
Ting Pei
Eighteen novel ciprofloxacin-histone deacetylase inhibitor (HDACi) conjugates were designed and synthesized from suberic acid and ciprofloxacin via esterification and amidation reaction. All conjugates were confirmed by the application of (...
[The in vitro inhibition and induction of cytochrome P450 activities by bentysrepinine: a novel candidate of anti-hepatitis B virus drug] [0.03%]
蝙蝠葛仁碱体外抑制和诱导细胞色素P450活性的作用研究-一种抗乙肝候选药物的非临床评价毒理学研究之一
Hui-rong Fan,Xiao-yan Ci,Wei Li et al.
Hui-rong Fan et al.
Bentysrepinine (Y101), a derivative of phenyalanine dipeptide, has a novel mechanism in the treatment of hepatitis B virus (HBV) infection with a good anti-HBV effect. In the present study, a fluorometric-based high throughput method using ...
[Effect and mechanism of miR-206/miR-613 on expression of OATP1B1] [0.03%]
[miR-206/miR-613对OATP1B1表达的影响及机制]
Yun Rao,Gao-feng Jin,Ming-yi Liu et al.
Yun Rao et al.
This study was designed to explore the effect and mechanism of miR-206/miR-613 on the expression of OATP1B1 gene. Bioinformatic analysis was used to predict the potential miRNAs target sites in 3’-untranslated region (3’-UTR) of OATP1B1 m...
[The reverse effects of allitridum on sodium current decrease caused by SCN5A-F1473S mutation] [0.03%]
全氢quina对SCN5A-F1473S突变所致钠电流减少的逆转作用
Zhong-qi Cai,Wan-peng Li,Xi Chen et al.
Zhong-qi Cai et al.
This study was designed to test the allitridum (All) activity in correction of sodium current decrease caused by SCN5A-F1473S mutation in HEK293 cells. The result may provide a theoretical basis for screening of new drugs in the treatment o...