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[Synthesis and anti-tumor activity of ciprofloxacin-histone deacetylase inhibitor conjugates]

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Eighteen novel ciprofloxacin-histone deacetylase inhibitor (HDACi) conjugates were designed and synthesized from suberic acid and ciprofloxacin via esterification and amidation reaction. All conjugates were confirmed by the application of (1)H NMR and HR-MS sp... ...