James M Krueger
James M Krueger
Cytokines including tumor necrosis factor alpha (TNF) play a role in sleep regulation in health and disease. Hypothalamic and cerebral cortical levels of TNF mRNA or TNF protein have diurnal variations with higher levels associated with gre...
PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM [0.03%]
家族性英国痴呆病患者脑外组织中的ABri分子N末端发生焦谷氨酸化现象
Yasushi Tomidokoro,Akira Tamaoka,Janice L Holton et al.
Yasushi Tomidokoro et al.
Amyloid molecules harboring pyroglutamate (pGlu) residue at the N-termini are considered to be important for the development of cerebral amyloidosis such as Alzheimer's disease and thought to be either spontaneously generated or being catal...
Jorge Ghiso,Yasushi Tomidokoro,Tamas Revesz et al.
Jorge Ghiso et al.
Cerebral amyloid angiopathy (CAA) is increasingly recognized as a major contributor of Alzheimer's disease (AD) pathogenesis. To date, vascular deposits and not parenchymal plaques appear more sensitive predictors of dementia. Amyloid depos...