Tanja Knaus,Francesco G Mutti
Tanja Knaus
The exquisite chemoselectivity and the intrinsic compatibility of enzymes have been widely exploited during the past decade for the development of multi-step biocatalytic reactions in one-pot. In this context, hydrogen-borrowing cascades pe...
Manisha DAS,Edison Zuniga,Iwao Ojima
Manisha DAS
A long standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug delivery systems have been explored to overcome this problem. These systems combine a powerful cytotoxic anticancer agent wit...
Stefano Costanzi
Stefano Costanzi
G protein-coupled receptors (GPCRs) are a large superfamily of membrane bound signaling proteins that are involved in the regulation of a wide range of physiological functions and constitute the most common target for therapeutic interventi...
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP) [0.03%]
靶向酸性致病组织：基于pH（低）插入肽(pHLIP)的新技术
Oleg A Andreev,Donald M Engelman,Yana K Reshetnyak
Oleg A Andreev
We discuss a peptide that targets cells in the acidic tissues that result from a range of pathological states, including tumours, and that can also translocate cell-impermeable cargo molecules across cell membranes in a pH-dependent manner....
Investigation of molecular recognition in biological systems using cellular membrane affinity chromatography [0.03%]
利用细胞膜亲和色谱研究生物系统中的分子识别现象
Irving W Wainer
Irving W Wainer
Cellular membrane affinity chromatography (CMAC) columns have been created through the immobilization of cellular membrane fragments on liquid chromatographic supports. A CMAC column containing the human organic cation transporter, CMAC(hOC...
Victor J Hruby,Josef Vagner
Victor J Hruby
Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a num...
Wei Zhang
Wei Zhang
A new technology for high-speed solution-phase parallel synthesis has been developed by the combination of microwave heating and fluorous tagging strategies. This article highlights several applications of this technology in the synthesis o...