C W Heath Jr,P R Fortin
C W Heath Jr
We (1) review the current status of epidemiologic studies of rheumatoid arthritis (RA); (2) consider the strengths and weaknesses of such studies and (3) offer suggestions regarding directions which future work might take. We will not exami...
G Murphy,R M Hembry
G Murphy
The role of proteinases in the extracellular breakdown of the connective tissue matrix during disease processes is outlined. Focussing on the matrix metalloproteinases, we present an overview of the mechanisms regulating their activity. Met...
Binding characteristics of human hybridoma IgG and IgM rheumatoid factors: influence of IgG isotype and carbohydrate content [0.03%]
人科斯米伊格G和伊格M类风湿因子的结合特性：伊格G亚类及糖链含量的影响
M M Newkirk,J Rauch,K Commerford
M M Newkirk
The interaction of human monoclonal rheumatoid factors (RF) with the Fc portion of IgG is complex. We have investigated the influence of the nature of the antigen (Fc) on the binding of hybridoma-generated RF derived from patients with rheu...
IgM rheumatoid factors in patients with rheumatoid arthritis derive from a diverse array of germline immunoglobulin genes and display little evidence of somatic variation [0.03%]
类风湿关节炎患者体内的IgM型类风湿因子源自多种免疫球蛋白基因，并且几乎没有体细胞变异的证据
V Pascual,K Victor,I Randen et al.
V Pascual et al.
Rheumatoid factors (RF) are present in the plasma of patients with rheumatoid arthritis (RA) although the site of synthesis of most of these antibodies is within the synovium. This report primary concerns RF of the IgM isotype. While a few ...
M Mannik
M Mannik
Rheumatoid factors (RF) participate in the pathogenesis of rheumatoid arthritis by formation of immune complexes. IgM-RF form complement activating immune complexes with IgG-containing antigen-antibody complexes. IgG-RF form unique immune c...
Rheumatoid factors: historical perspective, origins and possible role in disease [0.03%]
类风湿因子：历史回顾、起源及可能作用
R C Williams Jr
R C Williams Jr
The recognition of antibodies by the immune system is more complex than previously believed. Rheumatoid factor (RF), a family of autoantibodies against gammaglobulin, has long been recognized as an important biologic marker for rheumatoid a...
Excitement in synovium: the rapid evolution of understanding of rheumatoid arthritis and expectations for therapy [0.03%]
滑膜中的兴奋：类风湿关节炎的理解迅速演进及其治疗前景
E D Harris Jr
E D Harris Jr
Multiple events give rise to rheumatoid arthritis (RA) and many different elements create an overall pathological effect. It is highly unlikely that a single cause for RA will be identified. A greater appreciation of the multiple events tha...
What a rheumatologist needs to know about T cell receptor structure and function [0.03%]
风湿病学家需要了解的T细胞受体结构和功能知识
C G Fathman
C G Fathman
By understanding normal immune response, it has been possible to develop therapeutic strategies toward the treatment of autoimmune disease. The association of autoimmune disease with the major histocompatibility complex (MHC) class II gene ...
M Harth
M Harth
The relationship between the biologic activities of disease modifying antirheumatic drugs (DMARD) and their therapeutic effects are complex. Some DMARD are prodrugs, e.g., azathioprine; others may act in combination with endogenous substanc...