S-T Chou,Qixin Leng,A J Mixson
S-T Chou
Genome editing with the use of zinc finger nucleases has been successfully applied to variety of a eukaryotic cells. Furthermore, the proof of concept for this approach has been extended to diverse animal models from Drosophila to mice. Eng...
Carboxyethylpyrrole plasma biomarkers in age-related macular degeneration [0.03%]
年龄相关性黄斑变性中的丙酮基乙基吡咯类血浆生物标志物
Daniel Ardeljan,Jingsheng Tuo,Chi-Chao Chan
Daniel Ardeljan
Age-related macular degeneration causes irreversible central blindness in people over the age of 50 and is increasing in prevalence among elderly populations. There are currently limited treatment options available for the exudative form of...
D G Cordek,J T Bechtel,A T Maynard et al.
D G Cordek et al.
Hepatitis C virus (HCV) infects more than 3% of the world's population, leading to an increased risk of cirrhosis and hepatocellular carcinoma. The current standard of care, a combination of pegylated interferon alfa and ribavirin, is poorl...
Fostamatinib Disodium [0.03%]
氟西汀钠盐
Stephen P McAdoo,Frederick W K Tam
Stephen P McAdoo
The non-receptor tyrosine kinase Syk has a diverse range of biological functions, including a critical role in the intracellular signalling cascade for the surface immunoglobulin receptor on B lymphocytes, and the Fc receptor expressed on n...
GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA) [0.03%]
GAD65自身抗体及其作为1型糖尿病和成人隐匿性自身免疫糖尿病生物标志物的作用
Roberto Towns,Massimo Pietropaolo
Roberto Towns
One of the hallmarks of autoimmune diabetes is the presence of adaptive responses directed to neuroendocrine proteins. One of these proteins is glutamic acid decarboxylase (GAD). While GAD is widely distributed in neuroendocrine tissues, it...
Shaymaa S Mousa,Robert C Block,Shaker A Mousa
Shaymaa S Mousa
Given the strong genetic determinants of favorable HDL-C levels, the ability to procure the cardiovascular disease and longevity benefits associated with this mediator of the reverse cholesterol transport pathway through pharmaceutical inte...
ELIGLUSTAT TARTRATE: Glucosylceramide Synthase Inhibitor Treatment of Type 1 Gaucher Disease [0.03%]
eliglustat tartrate：用于治疗I型戈谢病的糖基鞘氨醇合酶抑制剂疗法
J A Shayman
J A Shayman
Eliglustat tartrate (Genz-112638) is a novel, orally administered agent currently in development for the treatment of lysosomal storage disorders, including type 1 Gaucher disease and Fabry disease. This glucosylceramide analogue acts as an...
ONCOLYTIC HERPES SIMPLEX VIRUS 1 (HSV-1) VECTORS: INCREASING TREATMENT EFFICACY AND RANGE THROUGH STRATEGIC VIRUS DESIGN [0.03%]
溶瘤HSV-1病毒载体的策略设计以提高治疗效果和适用范围
J Carson,D Haddad,M Bressman et al.
J Carson et al.
Viruses have long been considered potential anticancer treatments. Wild-type viruses have been tested as anticancer agents in clinical trials since the 1960s. The possibility of viral oncolysis as an alternate cancer therapy was transformed...
Jennifer Stedman,Aldo Roccaro,Xavier Leleu et al.
Jennifer Stedman et al.
Waldenstrom Macroglobulinemia (WM) is a B-cell disorder characterized by the infiltration of the bone marrow (BM) with lymphoplasmacytic cells, as well as detection of an IgM monoclonal gammopathy in the serum. WM is an incurable disease, w...
Berma M Kinsey,Thomas R Kosten,Frank M Orson
Berma M Kinsey
Although cocaine is illegal in most countries of the world, addiction is common and increasing in many populations, and the effectiveness of current treatment options for those afflicted has been very limited. The availability of an anti-co...