NRP1 transport of cancer therapeutics mediated by tumor-penetrating peptides [0.03%]
肿瘤穿透肽介导的NRP1癌症疗法转运
Qixin Leng,Martin C Woodle,A James Mixson
Qixin Leng
Whereas uptake of low molecular weight agents is generally inhibited in tumors due to high interstitial pressure, tumor uptake of macromolecules is increased due to enhanced permeability and retention (EPR). Small molecule drugs alone or in...
Dipongkor Saha,Seemin S Ahmed,Samuel D Rabkin
Dipongkor Saha
Malignant gliomas are the most common type of primary malignant brain tumor with no effective treatments. Current conventional therapies (surgical resection, radiation therapy, temozolomide (TMZ), and bevacizumab administration) typically f...
Crizotinib (PF02341066) as a ALK /MET inhibitor- Special Emphasis as a Therapeutic Drug Against Lung Cancer [0.03%]
克唑替尼(PF02341066)作为一种ALK/MET抑制剂及其作为肺癌治疗药物的特殊作用
Tobenna Nwizu,Rajani Kanteti,Ichiro Kawada et al.
Tobenna Nwizu et al.
There are a number of molecular abnormalities that can occur in normal cells to induce a malignant phenotype. Recently, the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) has been shown to have gain-of-function when partnered wit...
E A Griffiths,G Choy,S Redkar et al.
E A Griffiths et al.
SGI-110 is a second-generation hypomethylating prodrug whose active metabolite is the well-characterized drug decitabine. This novel compound is an oligonucleotide consisting of decitabine linked through a phosphodiester bond to the endogen...
Ilya Bezprozvanny,Thomas Klockgether
Ilya Bezprozvanny
Spinocerebellar ataxia type 2 (SCA2) and type 3 (SCA3) are autosomal-dominant neurodegenerative disorders. SCA2 primarily affects cerebellar Purkinje neurons. SCA3 primarily affects dentate and pontine nuclei and substantia nigra. Both diso...
Patrick C Gedeon,Bryan D Choi,John H Sampson et al.
Patrick C Gedeon et al.
Glioblastoma, the most common primary malignant brain tumor, is among the most difficult cancers to treat. Despite the aggressive standard of care, including surgical removal followed by radiotherapy with concomitant and adjuvant chemothera...
Sofie Claerhout,Philip L Lorenzi,John N Weinstein et al.
Sofie Claerhout et al.
Autophagy is a process in which cellular contents are captured in specialized, membrane-bounded vesicles and delivered to lysosomes for final degradation. Most studies support an inherent connection between autophagy and survival, but incre...
A3-adenosine receptors: design of selective ligands and therapeutic prospects [0.03%]
A3腺苷受体：特异性配体的设计和治疗前景
Kenneth A Jacobson,Hea O Kim,Suhaib M Siddiqi et al.
Kenneth A Jacobson et al.
Farnesoid X receptor-Acting through bile acids to treat metabolic disorders [0.03%]
法尼醇X受体——通过胆汁酸作用治疗代谢性疾病
Yanqiao Zhang
Yanqiao Zhang
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and plays an important role in maintaining bile acid, lipid and glucose homeostasis. Bile acids are endogenous ligands for FXR. However, bile acids may also activate...
Letermovir Treatment of Human Cytomegalovirus Infection Antiinfective Agent [0.03%]
人类巨细胞病毒的Letermovir治疗抗菌剂
Priya S Verghese,Mark R Schleiss
Priya S Verghese
Novel therapies are urgently needed for the management of cytomegalovirus (CMV) disease in high-risk patients. Currently licensed agents target the viral DNA polymerase, and although they are effective, they are fraught with toxicities to p...