Development of Selective Plane Illumination Surface Enhanced Raman Scattering Spectral Microscopy for Improved Cellular Imaging [0.03%]
用于改进细胞成像的选择性平面照明表面增强拉曼散射光谱显微镜的发展
Abigail E Smith,Zachary D Schultz
Abigail E Smith
The combination of optical microscopy and spectroscopy is a powerful tool for accessing both spatial and chemical information from a diverse range of samples. Applications of spectroscopic imaging techniques in biological samples are often ...
Assessment of unmixing approaches for the quantitation of SERS nanoparticles in highly multiplexed spectral images [0.03%]
用于高复用性光谱图像中SERS纳米颗粒定量的解混方法评估
Alexander Czaja,Samer Awad,Olga E Eremina et al.
Alexander Czaja et al.
Surface-enhanced Raman scattering nanoparticles (SERS NPs) offer powerful optical contrast features for imaging assays. Their gold core enhances the inelastic scattering cross section, allowing highly sensitive and rapid detection, and thei...
Non-negative matrix factorisation of Raman spectra finds common patterns relating to neuromuscular disease across differing equipment configurations, preclinical models and human tissue [0.03%]
非负矩阵分解发现拉曼光谱中与神经肌肉疾病相关的常见模式，涉及不同的设备配置、前临床模型和人体组织
James J P Alix,Maria Plesia,Chlöe N Schooling et al.
James J P Alix et al.
Raman spectroscopy shows promise as a biomarker for complex nerve and muscle (neuromuscular) diseases. To maximise its potential, several challenges remain. These include the sensitivity to different instrument configurations, translation a...
Coherent Raman scattering microscopy of lipid droplets in cells and tissues [0.03%]
细胞和组织中脂滴的相干拉曼散射显微镜研究
Chi Zhang
Chi Zhang
Lipid droplets (LDs) play a key role as the hub for lipid metabolism to maintain cellular metabolic homeostasis. Understanding the functions and changes of LDs in different pathological conditions is crucial for identifying new markers for ...
Machine learning using convolutional neural networks for SERS analysis of biomarkers in medical diagnostics [0.03%]
基于机器学习的卷积神经网络用于医疗诊断中生物标志物表面增强拉曼光谱分析
Joy Qiaoyi Li,Priya Vohra Dukes,Walter Lee et al.
Joy Qiaoyi Li et al.
Surface-enhanced Raman spectroscopy (SERS) has wide diagnostic applications because of narrow spectral features that allow multiplexed analysis. Machine learning (ML) has been used for non-dye-labeled SERS spectra but has not been applied t...
Bone quality assessment of osteogenic cell cultures by Raman microscopy [0.03%]
拉曼显微镜在成骨细胞培养骨质量评估中的应用研究
Gurjit S Mandair,Pieter Steenhuis,Michael A Ignelzi Jr et al.
Gurjit S Mandair et al.
The use of autologous stem/progenitor cells represents a promising approach to the repair of craniofacial bone defects. The calvarium is recognized as a viable source of stem/progenitor cells that can be transplanted in vitro to form bone. ...
SARS-CoV-2 severity classification from plasma sample using confocal Raman spectroscopy [0.03%]
基于共焦拉曼光谱的血浆样本新冠病毒肺炎病情分类研究
Arghya Banerjee,Ankit Halder,Priyanka Jadhav et al.
Arghya Banerjee et al.
The world is on the brink of facing coronavirus's (COVID-19) fourth wave as the mutant forms of viruses are escaping neutralizing antibodies in spite of being vaccinated. As we have already witnessed that it has encumbered our health system...
Quantification of the nonlinear susceptibility of the hydrogen and deuterium stretch vibration for biomolecules in coherent Raman micro-spectroscopy [0.03%]
相干拉曼显微光谱中生物分子氢和氘伸缩振动非线性率的定量研究
Dale Boorman,Iestyn Pope,Francesco Masia et al.
Dale Boorman et al.
Deuterium labelling is increasingly used in coherent Raman imaging of complex systems, such as biological cells and tissues, to improve chemical specificity. Nevertheless, quantitative coherent Raman susceptibility spectra for deuterated co...
Spectroscopic evidence of the effect of hydrogen peroxide excess on the coproheme decarboxylase from actinobacterial Corynebacterium diphtheriae [0.03%]
过量双氧水对棒状杆菌二氢丙醇脱羧酶考普罗血红素的作用的光谱证据
Federico Sebastiani,Chiara Niccoli,Hanna Michlits et al.
Federico Sebastiani et al.
The actinobacterial coproheme decarboxylase from Corynebacterium diphtheriae catalyzes the final reaction to generate heme b via the "coproporphyrin-dependent" heme biosynthesis pathway in the presence of hydrogen peroxide. The enzyme has a...
Lipid profiling using Raman and a modified support vector machine algorithm [0.03%]
基于拉曼光谱和改进支持向量机算法的脂质组学研究
Mariana C Potcoava,Gregory L Futia,Emily A Gibson et al.
Mariana C Potcoava et al.
Lipid droplets are dynamic organelles that play important cellular roles. They are composed of a phospholipid membrane and a core of triglycerides and sterol esters. Fatty acids have important roles in phospholipid membrane formation, signa...