[Structural, mechanistic and functional insights into topoisomerase II] [0.03%]
拓扑异构酶II的结构、机理和功能研究进展
Shang-Yao Qin,Yi-Min Yuan,Xin Hu et al.
Shang-Yao Qin et al.
Topoisomerases are nuclear enzymes that regulate the overwinding or underwinding of DNA helix during replication, transcription, recombination, repair, and chromatin remodeling. These enzymes perform topological transformations by providing...
["Gating-Spring" model and molecular basis of mechanotransduction in Drosophila melanogaster] [0.03%]
“ gating-spring ”模型与果蝇机械门控离子通道的力学转导机制分子基础研究
Xin Liang
Xin Liang
The sense of mechanical stimuli (e.g. force or deformation) in the environment underlies several important physiological processes, for example the perception of sound, touch, pain and acceleration. The key step in mechanosensation is to co...
Jian-Xin Tan,Ya-Jun Wang,Xi-Ke Zhu
Jian-Xin Tan
The thymus is a vital primary lymphoid organ that provides unique microenvironments for the proliferation, differentiation, and maturation of T cells. With advancing age, however, the thymus gradually undergoes age-related involution and re...
Yi Ren,Zhi-Cai Zuo,Tao-Mei Wan
Yi Ren
Resistin is a new adipokine found in vivo in recent years. Recent studies have indicated that resistin contributes to the development of insulin resistance and type 2 diabetes mellitus (T2DM) and mediates inflammatory reaction via different...
[Structure and function of the adapter protein Gab and its role in the development of tumor, inflammation and cardiovascular diseases] [0.03%]
衔接蛋白Gab的结构、功能及其在肿瘤、炎症和心血管疾病中的作用研究进展
An-Yi Li,Xiao-Xi Guo,Ying Liu et al.
An-Yi Li et al.
Gab proteins, Grb2 (growth factor receptor binding protein 2)-associated binder, are important scaffolding adapter proteins required by many signaling pathways. In mammals, the Gab proteins mainly consist of Gab1, Gab2 and Gab3, and are inv...
A rabbit pulmonary vein myocyte isolation method based on simultaneous heart and pulmonary vein perfusion [0.03%]
基于同时灌注心脏和肺静脉的兔肺静脉肌细胞分离方法
Lin-Lin Gao,Miao-Miao Zhang,Liang-Pin Zhang et al.
Lin-Lin Gao et al.
Myocytes in the pulmonary veins (PV) play a pivotal role in the development of paroxysmal atrial fibrillation (AF). It is therefore important to understand physiological characteristics of these cells. Studies on these cells are, however, m...
[AMP-activated protein kinase activation regulates adhesion of monocytes to vascular endothelial cells and the underlying mechanism] [0.03%]
[AMP活化的蛋白激酶活化调节单核细胞粘附于血管内皮细胞及其作用机制]
Hong-Bo Bai,Yun Wang,Yu-Hua Zhang et al.
Hong-Bo Bai et al.
The present study was aimed to explore the effect of AMP-activated protein kinase (AMPK) on monocyte adhesion to vascular endothelial cells and underlying molecular mechanism. Tumor necrosis factor α (TNFα)-activated human aortic endothel...
[AMPK activator down-regulates the expression of tissue factor in fulminant hepatitis mice] [0.03%]
[AMPK激活剂下调急性重型肝炎小鼠组织因子的表达]
Jie Dai,Ling Lin,Dan Zhou et al.
Jie Dai et al.
AMP activated protein kinase (AMPK) is a pivotal metabolic regulatory enzyme and novel target of controlling inflammation. Our previous studies had demonstrated that 5-amino-4-imidazolecarboxamide riboside (AICAR), an AMPK activator, attenu...
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor [0.03%]
染料木黄酮通过表皮生长因子诱导的人乳腺癌细胞系的增殖抑制作用
Jia-Qi Sui,Kun-Peng Xie,Ming-Jie Xie
Jia-Qi Sui
The aim of the present study was to investigate the mechanism of the inhibitory effect of luteolin on the proliferation of breast cancer cells induced by epidermal growth factor (EGF) in vitro. MTT assay was used to detect the inhibitory ef...
[Time course study of growth hormone releasing peptide-6-induced c-fos expression in neurons of feeding-related nuclei of hypothalamus] [0.03%]
生长抑素六肽诱导下丘脑摄食相关核团神经元c-fos表达的时间过程研究
Yan-Juan Yu,Jing Dong,Zheng-Yao Jiang et al.
Yan-Juan Yu et al.
The present study was aimed to explore the effects of intraperitoneal injection of growth hormone releasing peptide-6 (GHRP-6), a ghrelin receptor agonist, on food intake and neuronal activity of feeding-related nuclei in the hypothalamus o...