Tao-Ling Bi,Jin-Jian Sun,Yu-Zi Tian et al.
Tao-Ling Bi et al.
Exosomes are nanosized small membrane microvesicles of endocytic origin secreted by most cell types. Exosomes, through its carrying protein or RNA from derived cells, affect gene regulation networks or epigenetic reorganization of receptor ...
Shuang-Ping Meng,Bei Ma
Shuang-Ping Meng
P2X7 receptors are closely associated with inflammation, and they have been found to be expressed on colonic cells broadly. In animal model of colonic inflammation, ATP/P2X7 signaling mainly promotes inflammation, and a variety of cells, in...
[Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus] [0.03%]
葡萄糖转运蛋白4在高脂饮食诱导的认知改变及海马区糖代谢中的作用关系研究
Yun-Li Zhang,Lin Wang
Yun-Li Zhang
The hippocampus not only plays a role in appetite and energy balance, but also is particularly important in learning and memory. Figuring out the relationships of hippocampal glucose transporter 4 (GLUT4) with hippocampal glucose metabolism...
Li-Ming Chen,Mei Liu,Ying Liu
Li-Ming Chen
Ion channels and transporters represent two major types of pathways of transmembrane transport for ions. Distinct from ion channels which conduct passive ionic diffusion, ion transporters mediate active transport of ions. In the perspective...
Bing Xu,Yu Zhang,Jiu-Lin DU
Bing Xu
Blood-brain barrier (BBB) precisely controls the material exchange between the blood and brain tissue, and plays a critical role in the maintenance of brain microenvironment homeostasis. Brain microvascular endothelial cells connect tightly...
[Establishment of an anesthesia model induced by etomidate in larval zebrafish] [0.03%]
[异丙酚诱导的斑马鱼麻醉模型的建立]
Wen-Jie DU,Jiu-Lin DU,Tian Yu
Wen-Jie DU
Despite the wide application of general anesthetic drugs in clinic, it is still unclear how these drugs induce the state of general anesthesia. Larval zebrafish has emerged as an ideal model for dissecting the mechanism of neural systems du...
[Serum amyloid A promotes the inflammatory response via p38-MAPK/SR-BI pathway in THP-1 macrophages] [0.03%]
[SAA通过p38 MAPK/SR-BI信号通路促进THP-1单核细胞的炎症反应]
Ming-Yan Zhu,Yan Wang,Yu Wang et al.
Ming-Yan Zhu et al.
To investigate the effect and mechanism of serum amyloid A (SAA) on the expression of scavenger receptor class B type I (SR-BI) and inflammatory response in THP-1 macrophages, the human THP-1 cells were treated with SAA and p38-MAPK agonist...
[Inhibitory effect of total saponins of Panax notoginseng on rat bone marrow mesenchymal stem cell apoptosis] [0.03%]
田七总皂苷对骨髓间充质干细胞凋亡的抑制作用
Yong-Fang Ou,Xue-Kun Fu,Xing-Sha Mei et al.
Yong-Fang Ou et al.
The study was aimed to investigate the effects of total saponins of Panax notoginseng (tPNS) on cobalt chloride (CoCl2)-induced apoptosis of rat bone marrow mesenchymal stem cells (rBMSCs) and the underlying mechanism. rBMSCs were isolated ...
Target genes regulated by transcription factor E2F1 in small cell lung cancer [0.03%]
小细胞肺癌中转录因子E2F1的靶基因
Zun-Ling Li,Fei Jiao,Ying Ma et al.
Zun-Ling Li et al.
Previously, we have reported that transcription factor E2F1 expression is up-regulated in approximately 95% of small cell lung cancer tissue samples and closely associated with invasion and metastasis, but few studies have investigated spec...
[Neuroprotective effects of a novel antidiabetic drug (D-Ser2)Oxm on amyloid β protein-induced cytotoxicity] [0.03%]
[D- Ser2]Oxm新型抗糖尿病药物对淀粉样β蛋白诱导的细胞毒性的神经营养保护作用研究
Yu-Fei Han,Christian Holscher,Zhao-Jun Wang et al.
Yu-Fei Han et al.
The accumulation and neurotoxicity of amyloid β protein (Aβ) in the brain is one of major pathological hallmarks of Alzheimer's disease (AD). The effective drugs against Aβ have been still deficient up to now. According to a most recent ...