[Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease] [0.03%]
[miR-24对血管内皮细胞功能的调控及其在心血管疾病发生发展中的作用]
Wei Chen,He-Sheng Ou
Wei Chen
microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involv...
[Mechanism of cardiac atrophy under weightlessness/simulated weightlessness] [0.03%]
[微重力/模拟失重引起心肌萎缩的机制]
Guo-Hui Zhong,Shu-Kuan Ling,Ying-Xian Li
Guo-Hui Zhong
Cardiac remodeling is the heart's response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness i...
[Interactions between dopamine receptor and NMDA/type A γ-aminobutyric acid receptors] [0.03%]
[多巴胺受体与NMDA/型Aγ氨基丁酸受体相互作用]
Hui-Ying Chen,Ting-Jia Wei,Jing-Jin Weng et al.
Hui-Ying Chen et al.
Type A γ-aminobutyric acid receptors (GABAAR) and N-methyl-D-aspartate receptors (NMDAR) are the major inhibitory and excitatory receptors in the central nervous system, respectively. Co-expression of the receptors in the synapse may lead ...
[Development of three-dimensional breast cancer cell culture drug resistance model] [0.03%]
三维乳腺癌细胞系药敏模型的建立
Hong Xu,Wei Liu,Xiu-Zhen Zhang et al.
Hong Xu et al.
The aim of the present study was to develop three-dimensional (3D) culture model, a more pathologically relevant model, of human breast cancer for drug resistance study. MCF-7 cells were embedded within collagen gel to establish 3D culture ...
[c-Myc regulation of ATP-binding cassette transporter reverses chemoresistance in CD133(+) colon cancer stem cells] [0.03%]
c-Myc通过调节ATP结合盒转运蛋白逆转CD133阳性结直肠癌干细胞多药耐药性
Huan-Le Zhang,Ping Wang,Miao-Zhen Lu et al.
Huan-Le Zhang et al.
The present study was aimed to explore the role of c-Myc gene regulation in maintaining the self-renewal and drug-resistant properties of colon cancer stem cells (CSCs) and the underlying mechanism. CD133(+) cells were isolated by flow cyto...
[Biological function prediction of mir-210 in the liver of acute cold stress rat] [0.03%]
急性冷刺激大鼠肝脏mir-210生物学功能预测研究
Wen-Jin Guo,Shuai Lian,Jing-Ru Guo et al.
Wen-Jin Guo et al.
The study was aimed to observe mir-210 expression in liver tissue of acute cold stress rat and predict the function of mir-210 in cold stress. Thirty SPF Wistar male rats which were 12-week-old and weighed (340 ± 20) g were used. The rats ...
Involvement of spliced X-box binding protein 1 in renal fibrosis induced by unilateral ureteral obstruction in mice [0.03%]
小鼠单侧输尿管结扎诱导的肾纤维化中剪接型X盒结合蛋白1的作用机制研究
D-C Shao,Nai-Jun Miao,Jia-Jia Li
D-C Shao
Endoplasmic reticulum (ER) stress is involved in the process of kidney fibrosis. Spliced X-box binding protein 1 (XBP1S) is the key mediator of ER stress while its role in fibrosis is still poorly understood. This study was aimed to investi...
[Reduction in hypoxia-derived neuroinflammation and dysfunctional glutamate transporters by minocycline may restore hypoxia-injured cognition of neonatal rat] [0.03%]
二氧霉索通过降低缺氧所致的神经炎症和功能障碍的谷氨酸转运蛋白来恢复新生大鼠的缺氧损伤认知功能
Hong-Chun Li,Jie Xiao,Yi-Long Huang et al.
Hong-Chun Li et al.
The aim of the present study was to investigate the effects of minocycline on cognitive functions in neonatal rat after hypoxia exposure and the underlying mechanism. A model of hypoxic brain damage (HBD) was developed by exposing postnatal...
[Activity of glial cells in the olfactory bulb of Niemann-Pick disease type C1 mice] [0.03%]
[Niemann-Pick病C1型小鼠嗅球神经胶质细胞的活性]
Xin Yan,Liang Qiao,En-Hui Yang et al.
Xin Yan et al.
To study the pathological mechanisms of Niemann-Pick disease type C1, we observed the changes of activation of glial cells in the olfactory bulb of Npc1 mutant (Npc1(-/-)) mice. The genomic DNA was extracted from mouse tails for genotyping ...
[Refractive development and form-deprivation induced myopic refractive error in CBA/CaJ mice] [0.03%]
[CBA/CaJ小鼠的眼屈光发育及形式剥夺性近视模型的建立]
Yun-Yun Li,Kang-Wei Qian,Xiao-Hua Wu et al.
Yun-Yun Li et al.
Due to the advantages in genetic manipulation, mice have become one of the most commonly used mammalian models for the study of mechanisms underlying myopia development. However, the vast majority of laboratory mouse strains are incapable o...