Activation of necroptosis in a rat model of acute respiratory distress syndrome induced by oleic acid [0.03%]
油酸诱导的大鼠急性呼吸窘迫综合征中的坏死性凋亡激活
Long Pan,Dun-Chen Yao,Yu-Zhong Yu et al.
Long Pan et al.
The present study was aimed to investigate the role of necroptosis in the pathogenesis of acute respiratory distress syndrome (ARDS). The rat model of ARDS was induced by intravenous injection of oleic acid (OA), and observed for 4 h. The l...
Yi Li,Han Hao,Hai-Lin Zhang et al.
Yi Li et al.
Chronic pain represents a major clinical issue which so far is still in shortage of selective and effective treatment. Multiple components are involved in the pain processing, including peripheral, spinal and supraspinal levels of the nervo...
Qian Jiao,Xi-Xun DU,Jun-Xia Xie et al.
Qian Jiao et al.
Neural stem cells (NSCs) offer great promise for the treatment of multiple neurodegenerative diseases. However, the survival and differentiation rates of grafted cells in the host brain need to be enhanced. In this regard, understanding of ...
[Advances in the association of ATP-sensitive potassium channels and Parkinson's disease] [0.03%]
[腺苷三磷酸敏感型钾通道与帕金森病关联研究进展]
Xi-Xun DU,Kang Qin,Qian Jiao et al.
Xi-Xun DU et al.
ATP-sensitive potassium channels (KATP), as an inward rectifying potassium channel, are widely distributed in many types of tissues. KATP are activated by the depletion of ATP level and the increase in oxidative stress in cells. The activit...
Xiao Yang,Man-Man Xu,Jun Wang et al.
Xiao Yang et al.
Estrogen is a steroid hormone produced mainly by the ovaries. It combines with the nuclear receptors to exert the biological effects influencing the metabolism of body. Elevated levels of estrogen are often associated with altered iron leve...
Yan Yan,Xin-Yu Chai,Yao Chen et al.
Yan Yan et al.
Vision is one of the most important human sensations about the surrounding world. Visual deprivation not only markedly affects the life of blind people, but also gives a heavy burden to their family and the society. A visual prosthesis is a...
[Physiological and pathophysiological meanings of gastrointestinal smooth muscle motor unit SIP syncytium] [0.03%]
胃肠平滑肌运动单位SIP合胞体的生理和病理生理意义
Ni-Na Song,Wen-Xie Xu
Ni-Na Song
Gastrointestinal smooth muscle layer contains two kinds of interstitial cells with special differentiation, i.e., interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor α-positive (PDGFRα+) cells. The ICC and PDGFR...
Lu Gao,Tian-Wen Wu,Xin Ni
Lu Gao
Nitric oxide, carbon monoxide and hydrogen sulfide synthesized endogenously in living organisms produce an array of disparate biological effects, so as to be considered as gas transmitters. These three gaseous molecules play important roles...
Yi-Han Liu,Wei Kong
Yi-Han Liu
Vascular calcification is an active, invertible and highly regulated pathophysiological process, characterized by the deposition of hydroxyapatite crystal in vascular wall. Vascular calcification is classified into two types based on the si...
Icariin protects against MPP+-induced neurotoxicity in MES23.5 cells [0.03%]
淫羊藿次黄酮对MPP+诱导的MES23.5细胞神经毒性的作用及机制研究
Ai-Li Xu,Ming-Chun Jiang,Xiao-Han Chen et al.
Ai-Li Xu et al.
Icariin is the major bioactive component of Epimedium and has been demonstrated to be a potential drug for age-related diseases. The present study was aimed to investigate the neuroprotective properties of icariin against 1-methyl-4-phenylp...