[Protective effect of aliskiren on renal injury in AGT-REN double transgenic hypertensive mice] [0.03%]
阿利吉仑对AGT-REN双转基因高血压小鼠肾损伤的保护作用
Xiao-Ling Yang,Yan-Yan Chen,Hua Zhao et al.
Xiao-Ling Yang et al.
This study aims to investigate the effects of renin inhibitor aliskiren on kidney injury in human angiotensinogen-renin (AGT-REN) double transgenic hypertensive (dTH) mice and explore its possible mechanism. The dTH mice were divided into h...
[Inhibition of the mitochondrial metabolic enzyme OGDC affects erythroid development] [0.03%]
线粒体代谢酶OGDH的抑制会影响红细胞发育
Bin Hu,Mao-Hua Li,Han Gong et al.
Bin Hu et al.
Mitochondrial metabolism is crucial for providing energy and heme precursors during erythroid development. Oxoglutarate dehydrogenase complex (OGDC) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle, and its level graduall...
[Reduction in RNF125-mediated RIG-I ubiquitination and degradation promotes renal inflammation and fibrosis progression] [0.03%]
RNF125介导的RIG-I泛素化及降解减弱促进肾炎和纤维化的进展
Lu-Xin Li,Ting-Ting Ji,Li Lu et al.
Lu-Xin Li et al.
Persistent inflammation plays a pivotal role in the initiation and progression of renal fibrosis. Activation of the pattern recognition receptor retinoic acid-inducible gene-I (RIG-I) is implicated in the initiation of inflammation. This st...
[The pleiotropic role of MEF2C in bone tissue development and metabolism] [0.03%]
MEF2C在骨组织发育和代谢中的多效性作用
Hao-Jie Xiao,Rui-Qi Huang,Sheng-Jie Lin et al.
Hao-Jie Xiao et al.
The development of bone in human body and the maintenance of bone mass in adulthood are regulated by a variety of biological factors. Myocyte enhancer factor 2C (MEF2C), as one of the many factors regulating bone tissue development and bala...
Yang-Ming Zhang,Mai Lyu,Chen-Yang Wu et al.
Yang-Ming Zhang et al.
Heart failure (HF) is a common end-stage clinical manifestation of cardiovascular diseases, imposing substantial health-related burdens worldwide. With its high mortality rates and poor long-term prognosis, there is a pressing need for nove...
Zhao-Zhi Wen,Yi-Hang Yang,Dong Liu et al.
Zhao-Zhi Wen et al.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in multiple cellular energy metabolism, such as cell signaling, DNA repair, p...
[Therapeutic potential of ion channel modulation in Alzheimer's disease] [0.03%]
离子通道调节在阿尔茨海默病治疗中的潜力
Bing Huang,Cheng-Min Yang,Zhi-Cheng Lu et al.
Bing Huang et al.
Alzheimer's disease (AD), a prototypical neurodegenerative disorder, encompasses multifaceted pathological processes. As pivotal cellular structures within the central nervous system, ion channels play critical roles in regulating neuronal ...
[Progress on the mechanism and application of hyperbaric oxygen therapy for neurodegenerative diseases] [0.03%]
高压氧治疗神经退行性疾病的作用机制及应用进展
Fang-Fang Wang,Nan Wang,Heng-Rong Yuan et al.
Fang-Fang Wang et al.
In 2040, neurodegenerative diseases (NDD) will overtake cancer as the second leading cause of death after cardiovascular and cerebrovascular diseases. Therefore, the search for effective intervention measures has become the top priority to ...
Yu-Qi Niu,Jin-Jin Wang,Wen-Fei Cui et al.
Yu-Qi Niu et al.
The etiology of nervous system diseases is complicated, posing significant harm to patients and often resulting in poor prognoses. In recent years, the role of dopaminergic system in nervous system diseases has attracted much attention, and...
[The regulatory effect and mechanism of PGC-1α on mitochondrial function] [0.03%]
[PGC-1α对线粒体功能的调控作用及机制]
Song-Hua Nan,Chao-Jie Peng,Ying-Lin Cui
Song-Hua Nan
Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a core member of the PGC-1 family and serves as a transcriptional coactivator, playing a crucial regulatory role in various diseases. Mitochondria, the main site of...