[Research progress on the role of dopamine system in regulating hippocampal related brain functions] [0.03%]
多巴胺能系统调节海马相关脑功能的研究进展
Jing Ren,Wei-Yi Mo,Ling Wang et al.
Jing Ren et al.
Dopamine, as a catecholamine neurotransmitter widely distributed in the central nervous system, is involved in physiological functions such as motivation, arousal, reinforcement, and movement through various dopamine signaling pathways. The...
Qing Wang,Mei Liu,Zhang-Ji Dong
Qing Wang
As an important part of the cytoskeleton, microtubules play a crucial role in many cellular processes, such as cell division, intracellular transport, and maintaining cell morphology. The MAP1 family is an important family of microtubule-as...
Xiao-Juan Li,Bo Zheng,Ping Lan et al.
Xiao-Juan Li et al.
Alzheimer's disease (AD) is the commonest neurodegenerative disease that causes memory decline, cognitive dysfunction and behavior disorders in the aged people. Primary pathological hallmarks of AD include amyloid-β (Aβ), neurofibrillary ...
[Molecular mechanism of transcription factor PU.1 regulating erythroid differentiation and its role in hematological diseases] [0.03%]
转录因子PU.1调控红系分化的作用及机制及其在血液病中的作用
Zi-Jiang Yang,Dan Hu,Xiu-Juan Zhang
Zi-Jiang Yang
Transcription factor PU.1, as a core member of the ETS family, plays a pivotal role in the multi-lineage differentiation of hematopoietic stem cells, particularly in the regulation of erythroid differentiation. PU.1 orchestrates the process...
Targeting WEE1: a rising therapeutic strategy for hematologic malignancies [0.03%]
WEE1靶向：治疗血液系统恶性肿瘤的新兴策略
Hao-Bo Li,Thekra Khushafa,Chao-Ying Yang et al.
Hao-Bo Li et al.
Hematologic malignancies, including leukemia, lymphoma, and multiple myeloma, are hazardous diseases characterized by the uncontrolled proliferation of cancer cells. Dysregulated cell cycle resulting from genetic and epigenetic abnormalitie...
[Research progress on the protective effects of heat acclimation on the cardiova-scular system and its molecular mechanisms] [0.03%]
[热习服对心血管系统保护作用及机制研究进展]
Guo-Yu Li,Feng Guo,Zhuo Wang et al.
Guo-Yu Li et al.
Heat acclimation provides cardiovascular protection in high-temperature environments through multilevel mechanisms; however, the complete molecular basis of its effects remains unclear. In this paper, we systematically review the effects of...
[Exogenous administration of zinc chloride improves lung ischemia/reperfusion injury in rats] [0.03%]
氯化锌外源性给药改善大鼠肺缺血再灌注损伤
Shu-Yuan Wang,Jun-Peng Xu,Yuan Cheng et al.
Shu-Yuan Wang et al.
The aim of this study was to investigate the contribution of lung zinc ions to pathogenesis of lung ischemia/reperfusion (I/R) injury in rats. Male Sprague Dawley (SD) rats were randomly divided into control group, lung I/R group (I/R group...
[Steroid sulfatase inhibitor DU-14 prevents amyloid β-protein-induced depressive-like behavior and theta rhythm suppression in rats] [0.03%]
[sulph酸盐抑制剂DU-14防止AMYLOIDβ-PROTEIN诱导的大鼠类似抑郁的行为和theta节律的降低]
Xing-Hua Yue,Zhao-Jun Wang,Mei-Na Wu et al.
Xing-Hua Yue et al.
The hippocampus, a major component of the limbic system, is the most important region related to emotion regulation and memory processing. Cognitive impairment and depressive symptoms observed in Alzheimer's disease (AD) patients may be att...
[Glutamatergic neurons in thalamic paraventricular nucleus may be involved in the regulation of abnormal sleep behavior of Shank3 gene knockout mice] [0.03%]
伏隔核谷氨酸能神经元可能参与了SHANK3基因敲除小鼠异常睡眠行为的调控
Chang-Feng Chen,Lie-Cheng Wang,Yong Liu et al.
Chang-Feng Chen et al.
The purpose of this study was to investigate the anxiety-like behaviors, circadian rhythms and sleep, and to elucidate the possible underlying mechanisms of the abnormal sleep behavior in Shank3 gene knockout (Shank3-KO) mice. The anxiety-l...
[Multi-organ inflammatory phenotypes and transcriptomic characterization in an inflammation-driven mouse model of preeclampsia induced by LPS] [0.03%]
脂多糖诱发的母鼠炎症性子痫前期模型的多器官炎性表型及转录组特征分析
Ning Wang,Jing-Qiu Feng,Ying Xie et al.
Ning Wang et al.
Preeclampsia (PE) is a severe gestational disorder characterized by hypertension and proteinuria, with a subset of cases exhibiting an immune-driven phenotype marked by placental overexpression of proinflammatory cytokines and chronic infla...