[Digoxin inhibits migration and invasion of human gastric carcinoma MKN45 cells through down-regulation of AEG-1] [0.03%]
毒毛花苷G通过下调AEG-1抑制人胃癌MKN45细胞迁移及侵袭能力
Ming-Chen Cui,Xing-Hong Wang,Lei Yuan et al.
Ming-Chen Cui et al.
This study was designed to investigate the effect of digoxin on migration and invasion of human gastric carcinoma MKN45 cells and its possible mechanism. MKN45 cells were treated with different concentrations of digoxin for 24 h. The shRNA-...
[Inhibitory effects of capsaicin on migration and invasion of breast cancer MDA-MB-231 cells and its mechanism] [0.03%]
辣椒素对乳腺癌MDA-MB-231细胞迁移和侵袭的抑制作用及机制研究
Bai-He Li,Lei Yuan
Bai-He Li
The aim of this study was to investigate the effects of capsaicin on migration and invasion of breast cancer MDA-MB-231 cells and its possible mechanism. The MDA-MB-231 cells were incubated in the medium containing different concentrations ...
[Role of IgG plasma cells in the change of protein C system in ulcerative colitis] [0.03%]
溃疡性结肠炎患者凝血因子蛋白C系统变化与IgG浆细胞的关系研究
Xu-Hong Lin,Jun-Ling Guo,Yu-Qing Wen et al.
Xu-Hong Lin et al.
The present study is designed to explore the role of plasma cells in the change of protein C system (PCS) in ulcerative colitis (UC). Dextran sulfate sodium (DSS, 4% in concentration) was used to induce mouse UC model. The plasma cells and ...
[Effect of bilateral injection of calcitonin gene-related peptide into amygdala on learning and memory of mice] [0.03%]
[注射到小鼠杏仁体内的降钙素基因相关肽的双侧效应对其学习和记忆的影响]
Xin Wu,Wan-Jun Zheng,Ming-Hui Lv et al.
Xin Wu et al.
The aim of the present study was to explore the effects of different doses of calcitonin gene-related peptide (CGRP) injected into the central nucleus of amygdala on cognitive function, learning and memory of mice. C57BL/6J mice (30 days ol...
[Antidepressant effects of the extract of Dendrobium nobile Lindl on chronic unpredictable mild stress-induced depressive mice] [0.03%]
[Dendrobium nobile兰科植物提取物的抗抑郁作用及机制研究]
Ning Jiang,Lin-Xi Fan,Yu-Jie Yang et al.
Ning Jiang et al.
To investigate whether the extract of Dendrobium nobile Lindl (DNL) has an antidepressant effect on chronic unpredictable mild stress (CUMS)-induced depressive mice, 72 BALB/c male mice were randomly divided into the control group, the CUMS...
Acclimatization to middle altitude hypoxia protects against developmental and cognitive deficits caused by acute fetal hypoxia in mice [0.03%]
中度缺氧习服可保护小鼠免受急性胎儿缺氧引起的发育和认知缺陷损害
Hui-Lang Liu,Yong-Mei Sun,Chuan-Yu Li et al.
Hui-Lang Liu et al.
Acute fetal hypoxia (AFH) can elicit postnatal motor deficits and cognitive impairments. To test whether lifelong acclimatization to middle altitude (MA) hypoxia has protective effects on the impairments caused by AFH, ICR mice bred at 1 90...
[GLP-1/GIP/Gcg receptor Triagonist improves the cognitive behaviors in triple-transgenic mice of Alzheimer's disease] [0.03%]
GLP-1/GIP/Gcg受体激动剂改善三转基因小鼠阿尔茨海默病模型认知行为
Juan-Juan Jiao,Christian Hölscher,Tian Li et al.
Juan-Juan Jiao et al.
Alzheimer's disease (AD) is a progressively neurodegenerative disorder, which seriously affects human health but is still irreversible up to now. Recent studies indicate that type 2 diabetes mellitus (T2DM) is an important risk factor for A...
[Mechanisms underlying rat coronary arterial vasoconstriction induced by blockade of inward rectifier potassium channels with BaCl2] [0.03%]
氯化钡阻断大鼠冠状动脉内向整流钾通道所致血管收缩的机制研究
Fang-Wen Fan,Ze-Fang He,Meng Shi et al.
Fang-Wen Fan et al.
In order to explore the mechanisms underlying the vasoconstriction induced by blockade of inward rectifier K+ channels (Kir) with BaCl2, myogenic tone of isolated rat coronary artery (RCA) was recorded with wire myograph. The dependence of ...
[AMP-activated kinase activation inhibits transforming growth factor-β1 production in cardiac fibroblasts via targeting C/EBPβ] [0.03%]
活化型多效激酶通过作用于C/EBPβ抑制转化生长因子-β1的产生
Han Xiao,Cheng-Shi Piao,Rui-Fei Chen et al.
Han Xiao et al.
AMP-activated protein kinase (AMPK) activation has been shown to protect against fibrosis. However, the underlying mechanism remains unclear. Here we explored the effect of AMPK activation on transforming growth factor-β1 (TGFβ1) producti...
[Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression] [0.03%]
生长分化因子-15(GDF-15)对神经、心血管及肿瘤的影响
Dong-Dong Liu,Yan-Ai Mei
Dong-Dong Liu
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting ...