[Research progress of the interaction between RAAS and clock genes in cardiovascular diseases] [0.03%]
心血管疾病中RAAS与钟基因互作的研究进展
Rui-Ling Ma,Yi-Yuan Wang,Yu-Shun Kou et al.
Rui-Ling Ma et al.
The renin-angiotensin-aldosterone system (RAAS) is crucial for regulating blood pressure and maintaining fluid balance, while clock genes are essential for sustaining biological rhythms and regulating metabolism. There exists a complex inte...
[Research advances in the mechanisms of circadian regulation in heart failure] [0.03%]
心力衰竭circadian节律调控机制研究进展
Qiong Wang,Jia-Yang Zhang,Le-Jia Qiu et al.
Qiong Wang et al.
The circadian clock is an endogenous time-keeping system that maintains physiological homeostasis by integrating environmental and genetic interactions. Heart failure is a complex clinical syndrome characterized by structural abnormalities ...
[Research progress on biological clock-targeting small-molecule compounds for intervention in metabolic diseases] [0.03%]
生物钟调控代谢的小分子化合物研究进展
Qing-Qing Wang,Chang Liu
Qing-Qing Wang
The circadian rhythm regulates the 24-hour physiological and behavioral cycles through endogenous molecular clocks governed by core clock genes via the transcription-translation feedback loop (TTFL). In mammals, the suprachiasmatic nucleus ...
[Advances in molecular mechanisms and neuronal circuits underlying circadian rhythms in Drosophila] [0.03%]
[Drosophila昼夜节律的分子机理及神经环路的研究进展]
Wu-Yan Xu,Chun-Xue Qiao,Fei-Xiang Li et al.
Wu-Yan Xu et al.
Circadian rhythms are core regulatory mechanisms that evolved to align biological functions with the Earth's rotation. These rhythms are conserved across organisms from unicellular life to multicellular species and play essential roles in m...
[Advances in the role of protein post-translational modifications in circadian rhythm regulation] [0.03%]
蛋白质修饰的昼夜节律功能研究进展
Zi-Di Zhao,Qi-Miao Hu,Zi-Yi Yang et al.
Zi-Di Zhao et al.
The circadian clock plays a critical role in regulating various physiological processes, including gene expression, metabolic regulation, immune response, and the sleep-wake cycle in living organisms. Post-translational modifications (PTMs)...
[Research advance on the role of gut microbiota and its metabolites in juvenile idiopathic arthritis] [0.03%]
肠道菌群及其代谢物在儿童关节炎发病机制中的研究进展
Ao-Hui Peng,You-Jia Chen,Jin-Xuan Gu et al.
Ao-Hui Peng et al.
Juvenile idiopathic arthritis (JIA) is the most common condition of chronic rheumatic disease in children. JIA is an autoimmune or autoinflammatory disease, with unclear mechanism and limited treatment efficacy. Recent studies have found a ...
[Research progress on molecular mechanism of resistance training-induced skeletal muscle hypertrophy: the crucial role of mTOR signaling] [0.03%]
[抵抗运动诱导骨骼肌肥大分子机制的研究进展：mTOR信号通路的关键作用]
Yong-Cai Zhao,Tao Huang
Yong-Cai Zhao
Resistance training promotes protein synthesis and hypertrophy, enhancing strength of skeletal muscle through the activation of the mammalian target of rapamycin (mTOR) and the subsequent increases of ribosome biogenesis and translation cap...
[Research progress on the regulation of ferroptosis by non-coding RNAs in esophageal squamous cell cancer] [0.03%]
非编码RNA调控食管鳞癌铁死亡的研究进展
Jia-Min Wang,Pan Liu,Rui Zhu et al.
Jia-Min Wang et al.
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy of the digestive tract that poses a significant threat to human health, with an incidence rate that continues to rise globally. Increasing research highlights the crucial r...
[Advances in the function and mechanisms of stearoyl-CoA desaturase 1 in metabolic diseases] [0.03%]
[硬脂酰辅酶A去饱和酶1的功能及代谢性疾病中的作用机制研究进展]
Qin Sun,Xiao-Rui Xing,Cheng Liu et al.
Qin Sun et al.
Metabolic diseases characterized by an imbalance in energy homeostasis represent a significant global health challenge. Individuals with metabolic diseases often suffer from complications related to disorders in lipid metabolism, such as ob...
Fu-Sheng Ding,Si-Si Yang,Liang Zheng et al.
Fu-Sheng Ding et al.
Astrocytes are a crucial type of glial cells in the central nervous system, not only maintaining brain homeostasis, but also actively participating in the transmission of information within the brain. Astrocytes have a complex structure tha...