[Inhibition of activation of astrocytes in dorsal hippocampal CA1 relieves lipopolysaccharide-induced cognitive impairment] [0.03%]
抑制海马CA1区星形胶质细胞活化缓解脂多糖所致认知障碍
Si-Qi Jing,Ying Zhang,Wei-Guo Shi et al.
Si-Qi Jing et al.
This study aimed to investigate whether inhibiting the activation of astrocytes in the dorsal hippocampal CA1 (dCA1) region could ameliorate lipopolysaccharide (LPS)-induced cognitive impairment in mice. Mice were intraperitoneally injected...
Peng-Yu Chen,Hua Guo,Yu-Nan Wang et al.
Peng-Yu Chen et al.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Defects in the regulatory T cells (Treg cells) play a key role in breaking immune tolerance in SLE patients. This study investigates the causes of impaired Treg cell functi...
[Engulfment of senescent erythrocytes by endothelial cells promotes endothelial-to-mesenchymal transition] [0.03%]
衰老红细胞被内皮细胞吞噬促进内皮-间充质转化
Cheng-Lin Huang,Wei-Li Shen
Cheng-Lin Huang
Endothelial cells, as non-professional phagocytes, play a role in clearing senescent red blood cells (RBCs). This study explores the phenotypic differentiation of endothelial cells following the phagocytosis of senescent RBCs. A hypertensiv...
[Research progress on the role of miR-132 in the pathogenesis of depression] [0.03%]
抑郁症发病机制中miR-132作用的研究进展
Ding-Lun Meng,Qing-Yan Wang,Xin Zhang et al.
Ding-Lun Meng et al.
The prevalence of depression, a common mental disorder in clinical practice, has been continuously increasing in recent years, with its intricate etiology and pathogenesis incompletely understood. MicroRNA (miRNA), a highly conserved and wi...
[The role and mechanism of branched-chain amino acids in tumorigenesis and progression] [0.03%]
支链氨基酸在肿瘤发生发展中的作用及机制研究进展
Ren Zheng,Chen-Chen Hu,Yuan-Jie Sun et al.
Ren Zheng et al.
As essential amino acids, branched-chain amino acids (BCAAs) have attracted much attention in the field of tumor metabolism in recent years. This article reviews the metabolic characteristics of BCAAs in tumors and discusses their involveme...
[Advances in the regulation of pancreatic islet β-cell identity plasticity by exercise in type 2 diabetes mellitus] [0.03%]
运动改善2型糖尿病胰岛β细胞身份可塑性的表观遗传机制研究进展
Ke Yao,Nan-Nan Jia,Hang Chu et al.
Ke Yao et al.
Loss of pancreatic islet β-cell identity is considered to be one of the major factors for impaired insulin secretion in diabetes mellitus. Pancreatic islet β-cell identity plasticity and the regulatory mechanisms of related factors have a...
[Progress in targeting endogenous neurogenesis for the treatment of ischemic stroke] [0.03%]
[针对内源性神经发生治疗缺血性卒中的研究进展]
Meng-Tao Wang,Hai-Lin DU,Fei Hao et al.
Meng-Tao Wang et al.
Stroke is the leading cause of death and disability in China and the second in the world. A large number of neurons died after ischemic stroke. Due to the limited regenerative capacity of central nervous system, severely restricted neuronal...
[Research progress on the correlation between hemoglobin gene polymorphism and high-altitude hypoxia adaptation] [0.03%]
[血红蛋白基因多态性与高原低氧适应的相关性研究进展]
Qian Ji,Yue-Mei Sun,Ying-Fei Zhang et al.
Qian Ji et al.
Hemoglobin in red blood cells is essential for oxygen binding, transport, and delivery, functioning as a molecular switch between the deoxygenated (T-state) and oxygenated (R-state) conformations. Genetic polymorphisms in hemoglobin can sig...
[Research progress on the signaling pathways of curcumin in obesity treatment] [0.03%]
姜黄素治疗肥胖信号转导通路的研究进展
Shen Zhang,Hua Yu,Ying Li
Shen Zhang
Obesity and related metabolic syndrome have become a worldwide health crisis. Browning of white adipose tissue, reducing triglyceride content in adipocytes, decreasing the number of adipocytes and reducing inflammation and oxidative stress ...
Jia-Qi Chen,Yue-Jing He,Hui-Ling Zheng et al.
Jia-Qi Chen et al.
Lactylation is one of the post-translational modifications of proteins, a process in which lactyl residues bind to the lysine residues of proteins. This modification can alter the structure, stability, and function of proteins, which in tur...