[Steroid sulfatase inhibitor DU-14 prevents amyloid β-protein-induced depressive-like behavior and theta rhythm suppression in rats] [0.03%]
[sulph酸盐抑制剂DU-14防止AMYLOIDβ-PROTEIN诱导的大鼠类似抑郁的行为和theta节律的降低]
Xing-Hua Yue,Zhao-Jun Wang,Mei-Na Wu et al.
Xing-Hua Yue et al.
The hippocampus, a major component of the limbic system, is the most important region related to emotion regulation and memory processing. Cognitive impairment and depressive symptoms observed in Alzheimer's disease (AD) patients may be att...
[Glutamatergic neurons in thalamic paraventricular nucleus may be involved in the regulation of abnormal sleep behavior of Shank3 gene knockout mice] [0.03%]
伏隔核谷氨酸能神经元可能参与了SHANK3基因敲除小鼠异常睡眠行为的调控
Chang-Feng Chen,Lie-Cheng Wang,Yong Liu et al.
Chang-Feng Chen et al.
The purpose of this study was to investigate the anxiety-like behaviors, circadian rhythms and sleep, and to elucidate the possible underlying mechanisms of the abnormal sleep behavior in Shank3 gene knockout (Shank3-KO) mice. The anxiety-l...
[Multi-organ inflammatory phenotypes and transcriptomic characterization in an inflammation-driven mouse model of preeclampsia induced by LPS] [0.03%]
脂多糖诱发的母鼠炎症性子痫前期模型的多器官炎性表型及转录组特征分析
Ning Wang,Jing-Qiu Feng,Ying Xie et al.
Ning Wang et al.
Preeclampsia (PE) is a severe gestational disorder characterized by hypertension and proteinuria, with a subset of cases exhibiting an immune-driven phenotype marked by placental overexpression of proinflammatory cytokines and chronic infla...
Conserved translational control in cardiac hypertrophy revealed by ribosome profiling [0.03%]
基于核糖体谱分析揭示心室肥厚中保守的翻译调控机制
Bao-Sen Wang,Jian Lyu,Hong-Chao Zhan et al.
Bao-Sen Wang et al.
A primary hallmark of pathological cardiac hypertrophy is excess protein synthesis due to enhanced translational activity. However, regulatory mechanisms at the translational level under cardiac stress remain poorly understood. Here we exam...
[Effects of resistance combined with aerobic chrono-exercise on common carotid artery elasticity and hemodynamics in young men] [0.03%]
抵抗运动结合有氧时序锻炼对青年男性颈总动脉弹性及血流动力学的影响
Miao-Xin Jiao,Bing-Yi Shen,Hai-Bin Liu et al.
Miao-Xin Jiao et al.
The purpose of the present study was to investigate the effects of resistance combined with aerobic chrono-exercise on the common carotid artery elasticity and hemodynamics. 24 healthy young men (21.96±0.43 years old) underwent a single ac...
[Misaligned light entrainment causes metabolic disorders in Chrono knockout mice] [0.03%]
[时差基因敲除小鼠光照同步失谐引起代谢障碍]
Ruo-Han Wang,Shao-Ying Lan,Bo-Yuan Cao et al.
Ruo-Han Wang et al.
Most of the life forms on Earth have gradually evolved an endogenous biological clock under the long-term influence of periodic daily light-dark cycles. This biological clock system plays a crucial role in the orderly progression of life ac...
Bing-Xin Gao,Cao Wang,Rui-Xian Jiang et al.
Bing-Xin Gao et al.
In recent years, China's manned space program has advanced rapidly, with deep space exploration missions such as manned lunar landing steadily progressing, leading to a significant extension of astronauts' duration in outer space. In this c...
[Circadian and non-circadian regulation of the male reproductive system and reproductive damage: advances in the role and mechanisms of clock genes] [0.03%]
[生物钟基因在昼夜和非昼夜节律调节男性生殖系统及生殖损害作用与机制的研究进展]
Meng-Chao He,Ying-Zhong Dai,Yi-Meng Wang et al.
Meng-Chao He et al.
Recently, male reproductive health has attracted extensive attention, with the adverse effects of circadian disruption on male fertility gradually gaining recognition. However, the mechanism by which circadian disruption leads to damage to ...
Circadian rhythms and their roles in the pathogenesis and treatment of depression [0.03%]
生物节律与抑郁症发病机制及治疗反应的关系
William Kojo Smith,Zhao-Min Zhong,Willow Tsanzi Wang et al.
William Kojo Smith et al.
Major depressive disorder (MDD) affects people all over the world, and yet, its etiology is complex and remains incompletely understood. In this review, we aim to assess recent advances in understanding depression and its regulation, as wel...
Deng-Feng Liu,Yi-Chun Zhang,Jia-Da Li
Deng-Feng Liu
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intellectual developmental disorder (IDD), are highly prevalent and lack effective treatments, posing signif...