[Single-nucleus transcriptome of the gracile nucleus reveals multi-modular complex functional genes in excitatory projection neurons] [0.03%]
单核转录组揭示了薄束核兴奋性投射神经元的多模态复杂功能基因
Ting Si,Qing-Jian Han
Ting Si
The gracile nucleus (GR), conventionally regarded as a primary relay in the ascending somatosensory pathway, plays a pivotal role in processing fine-touch, vibration, and proprioceptive information originating from the lower body. The fidel...
[Differential effects of GluN2A and GluN2B subunits in the medial prefrontal cortex on chronic pain and anxiety/depressive-like behaviors] [0.03%]
medial前额叶皮层GluN2A和GluN2B亚基在慢性疼痛以及焦虑和抑郁样行为中的不同作用
Jia-Li Ding,Hui-Ran Yang,Yu-Qiu Zhang et al.
Jia-Li Ding et al.
This study aimed to investigate the differential roles of GluN2A and GluN2B subunits of N-methyl-D-aspartate receptor (NMDAR) in the medial prefrontal cortex (mPFC) and their downstream signaling pathways in a mouse model of chronic constri...
Mice with postsurgical pain exhibit age-dependent spinal microglial activation and inhibitory synapse loss [0.03%]
术后疼痛的小鼠表现出脊髓微胶质活化和抑制性突触丧失的年龄依赖性
Jia-Ning Wang,Yu Shen,Shi-Hao Wang et al.
Jia-Ning Wang et al.
Persistent postsurgical pain is a major clinical concern, especially in the aging population, who represent a growing proportion of surgical patients. Although age is a known pain risk factor, the mechanisms driving age-related vulnerabilit...
Oxytocin relieves visceral hypersensitivity through GABAB1-TRPV1 in rats with irritable bowel syndrome [0.03%]
催产素通过GABAB1-TRPV1信号缓解内脏高敏感及肠易激综合征症状
Fei Fan,Yang Cao,Zheng-Qing He et al.
Fei Fan et al.
Oxytocin has been found to modulate and improve pain in humans, but the mechanisms underlying these antinociceptive properties, especially in visceral hypersensitivity, are still unclear. Irritable bowel syndrome (IBS) models were establish...
A glutamatergic Sp5C-STN circuit mediates chronic migraine in mice [0.03%]
小鼠慢性偏头痛的谷氨酸Sp5C-STN环路机制研究
Liu Tang,Ying-Qi Cheng,Wei Gui et al.
Liu Tang et al.
Chronic migraine (CM) is a prevalent and highly debilitating neurological disorder. Functional magnetic resonance imaging (fMRI) studies have demonstrated associations between abnormal brain region activation and CM, yet the underlying comp...
[The involvement of claustrum/insular cortex-locus coeruleus neural pathway in modulating neuropathic pain in mice] [0.03%]
[参与调控小鼠神经病理性疼痛的屏状核/岛叶皮质-蓝斑神经通路]
Lyu-La Pan,Tao Gong,Zi-Ang Li et al.
Lyu-La Pan et al.
To investigate the fiber connections between the claustrum (CLA)/insular cortex (IC) and the locus coeruleus (LC), as well as the role of this neural pathway in neuropathic pain, morphological techniques, patch-clamp recording, and chemogen...
[Mechanistic insights into NLRP3 inflammasome regulation of chronic pain] [0.03%]
[NLRP3炎性小体调控慢性疼痛的机制研究]
Zong-Zhi Yang,Jie Wu,Xiao-Lan Huang et al.
Zong-Zhi Yang et al.
The NLRP3 inflammasome, a pivotal effector of the innate immune system, has emerged as a critical regulator in the initiation and maintenance of chronic pain. Accumulating evidence demonstrates that NLRP3 inflammasome activation in the peri...
[Advances in the study of the regulation and mechanism of purinergic P2X receptors in visceral pain] [0.03%]
[内脏痛觉过敏的嘌呤能P2X受体调控及机制研究进展]
Hao-Bo Zhang,Jing Lei,Hao-Jun You
Hao-Bo Zhang
Visceral pain (VP) refers to pathological pain originating from the thoracic, abdominal, or pelvic regions. Characterized by poor localization and prolonged duration, VP significantly impacts the physical and mental health of patients. Unli...
[Research progress on the neural mechanisms of alcohol use disorder-induced hyperalgesia] [0.03%]
酒精使用障碍诱导痛觉过敏的神经机制研究进展
Ling-Jie Ma,Xiao-Hong Chen,Yong-Jing Gao
Ling-Jie Ma
Alcohol use disorder (AUD) is a complex chronic relapsing brain disease that poses significant threats to individual health and public healthcare systems. Hyperalgesia, an increased sensitivity to pain, has been recognized as a critical fac...
[Research progress on mitochondrial genetic mechanisms underlying the onset of migraine] [0.03%]
migraine的线粒体遗传机制研究进展
Meng-Yuan Qiu,Huai-Lian Guo
Meng-Yuan Qiu
Migraine is a common primary headache disorder in clinical practice, and its recurrent nature severely impairs patients' quality of life. Data from the 2021 Global Burden of Disease Study indicate that migraine imposes a heavy burden on pat...