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Qian Ji et al.
Hemoglobin in red blood cells is essential for oxygen binding, transport, and delivery, functioning as a molecular switch between the deoxygenated (T-state) and oxygenated (R-state) conformations. Genetic polymorphisms in hemoglobin can sig...
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Shen Zhang,Hua Yu,Ying Li
Shen Zhang
Obesity and related metabolic syndrome have become a worldwide health crisis. Browning of white adipose tissue, reducing triglyceride content in adipocytes, decreasing the number of adipocytes and reducing inflammation and oxidative stress ...
Jia-Qi Chen,Yue-Jing He,Hui-Ling Zheng et al.
Jia-Qi Chen et al.
Lactylation is one of the post-translational modifications of proteins, a process in which lactyl residues bind to the lysine residues of proteins. This modification can alter the structure, stability, and function of proteins, which in tur...
[Clinical manifestations and pathological mechanisms of central post-stroke pain at different lesion sites] [0.03%]
不同病损部位中枢性卒中后痛的临床表现和病理机制
Xiao-Li Chen,Jing Lei,Hao-Jun You
Xiao-Li Chen
Central post-stroke pain (CPSP), a common sequela of stroke, is a type of central neuropathic pain characterized by spontaneous pain, hyperalgesia, and allodynia, which significantly hinders post-stroke rehabilitation. The pathophysiology o...
[SOX5: A core transcription factor from development to multi-system disease regulation] [0.03%]
SOX5：从发育到多系统疾病调控的核心转录因子
Guang-Xuan Hu,Yang Yang,Jin-Shi Guo et al.
Guang-Xuan Hu et al.
SOX5, as an important member of the SOX transcription factor family, is widely involved in various physiological and pathological processes. SOX5 regulates the expression of key genes involved in cell differentiation, proliferation, and dev...
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Hua Tian,Hong-Li Gao,Li-Yan Fu et al.
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The cardiovascular center is widely distributed at all levels from the spinal cord to the cerebral cortex. It regulates the activity of the autonomic nervous system through various neurotransmitters, thereby further modulating cardiovascula...
[Common characteristics and regulatory mechanisms of airway mucus hypersecretion in lung disease] [0.03%]
气道过度分泌的共性特征及调控机制
Ze-Qiang Lin,Shi-Man Pang,Si-Yuan Zhu et al.
Ze-Qiang Lin et al.
In a healthy human, the airway mucus forms a thin, protective liquid layer covering the surface of the respiratory tract. It comprises a complex blend of mucin, multiple antibacterial proteins, metabolic substances, water, and electrolytes....
Fei Sun,Yu Sun,En-Xu Liu et al.
Fei Sun et al.
Intervertebral disc degeneration (IDD) is the main cause of low back pain. Immune cells play an extremely important role in regulating the progression of IDD by interacting with nucleus pulposus (NP) cells and the extracellular matrix (ECM)...
[Recent advances in the mechanism of insulin-like growth factor-1-mediated exercise-induced improvement of skeletal muscle atrophy] [0.03%]
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Qian Wang,Yi-Min He,Yu-Mo Dong et al.
Qian Wang et al.
Skeletal muscle atrophy is characterized by a reduction in both the size and quantity of skeletal muscle fibers, resulting in impaired muscle strength and function. It mainly includes disuse muscle atrophy, aging muscle atrophy, denervated ...
[Research progress on the role of extracellular vesicles in the repair of skeletal muscle membrane injury] [0.03%]
外泌体在骨骼肌膜损伤修复中作用的研究进展
Yi-Long Liu,Ying Wu
Yi-Long Liu
The timely and efficient repair of the plasma membrane in skeletal muscle cells following injury is critical for maintaining cellular function and tissue integrity. Extracellular vesicles (EVs) play a pivotal role in this process through mu...