Qian-Qian Ju,Cheng Sun
Qian-Qian Ju
Metabolic dysregulation is a hallmark of cancer. Mutations in genes encoding key enzymes of the tricarboxylic acid (TCA) cycle can result in the accumulation of "oncometabolites". These metabolites play essential roles in tumor initiation, ...
[Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression] [0.03%]
近期非编码RNA介导的PI3K/AKT/mTOR信号通路调控在三阴性乳腺癌发生发展中的研究进展
Zhu Huang,Wen-Jing Li,Zi-Juan Song et al.
Zhu Huang et al.
Triple-negative breast cancer (TNBC) is characterized by high invasion and metastasis, poor prognosis, and high mortality, making it the most aggressive form of breast cancer. Currently, there is still a lack of effective therapeutic target...
[The role of mesenchymal stem cells in cancer therapy: friend or foe?] [0.03%]
间充质干细胞在癌症治疗中的作用：朋友还是敌人？
Shu-Ting Zhou,Jian-Ping Jiang
Shu-Ting Zhou
Mesenchymal stem cells (MSCs) can adhere to plastic surfaces and express specific differentiation markers such as CD73, CD90, and CD105. They can differentiate into osteoblasts, chondrocytes, or adipocytes in vitro and do not express marker...
[Mechanism of mitochondrial transcellular transfer in cerebral ischemia-reperfusion injury] [0.03%]
脑缺血再灌注损伤线粒体跨细胞转移机制探讨
Rui-Shu An,Wen-Xiu Qin,Jian Yang et al.
Rui-Shu An et al.
Ischemic stroke (IS) is an acute cerebrovascular disease in which blood circulation to brain tissue and neurological function are impaired due to obstruction of cerebral blood vessels, and it is one of the most common causes of death worldw...
[Research progress of sleep-wake neural circuit mediated by hypothalamus] [0.03%]
[下丘脑介导的觉醒-睡眠神经环路研究进展]
Bin-Hao Long,Ting-Ting Dou,Cui Ma et al.
Bin-Hao Long et al.
The hypothalamus is a critical central hub for regulating sleep-wake patterns in organisms, maintaining the balance between daily activity and rest by modulating sleep-wake-related neural circuits. This article reviews research on hypothala...
Shuang Zhang,Ke Wang,Yue Wang et al.
Shuang Zhang et al.
Ischemic stroke is a common cerebrovascular disease with an increasing incidence year by year, and it remains one of the leading causes of death and disability worldwide. The β2-adrenergic receptor (β2-AR), a member of the G protein-coupl...
Cheng-Bin Tang,Wen-Hao Chen,Chun-Ling Li et al.
Cheng-Bin Tang et al.
Hypertension is one of the most important risk factors for cardiovascular, cerebrovascular and renal diseases. The molecular mechanism of hypertension is not fully understood largely due to the complexity of pathogenesis involving many fact...
[Spinal lncRNA_RT1-CE10 attenuates chronic visceral hypersensitivity in rats with irritable bowel syndrome via inhibiting microglial activation] [0.03%]
脊髓长链非编码RNA_RT1-CE10通过抑制微胶质细胞活化缓解肠易激综合征大鼠慢性内脏高敏感性
Zi-Han Liu,Yi-Qian Liu,Qian-Li Zhang et al.
Zi-Han Liu et al.
The purpose of the study was to investigate the role of the long non-coding RNA (lncRNA)_RT1-CE10 and its molecular mechanisms in chronic visceral pain of rats with irritable bowel syndrome (IBS). Sprague-Dawley (SD) rats were exposed to co...
[5-HT1A receptors in the anterior cingulate cortex mediate electroacupuncture to alleviate the affective pain in rats] [0.03%]
前扣带回5-ht1a受体在电针镇痛中的作用
Jie Shen,Kai-Ni Wang,Jie Gao et al.
Jie Shen et al.
This study aimed to investigate the role of 5-hydroxytryptamine 1A (5-HT1A) receptors in the anterior cingulate cortex (ACC) in regulating the affective pain in rats. In the ACC, normal saline (NS), the 5-HT1A receptor agonist 8-OH-DPAT or ...
[Various models of itch induction and their relationship to pain sensitivity] [0.03%]
[多种痒的诱发模型及其与痛敏感性关系的研究]
Xiao-Ran Ding,Xiu-Yi Han,Hong-Wei Sun et al.
Xiao-Ran Ding et al.
Pruritus, a complex multidimensional sensation accompanying diverse dermatological and systemic disorders, affects a substantial global population. Nevertheless, the pathophysiological mechanisms underlying chronic pruritus remain incomplet...