[Advances in the study of the regulation and mechanism of purinergic P2X receptors in visceral pain] [0.03%]
[内脏痛觉过敏的嘌呤能P2X受体调控及机制研究进展]
Hao-Bo Zhang,Jing Lei,Hao-Jun You
Hao-Bo Zhang
Visceral pain (VP) refers to pathological pain originating from the thoracic, abdominal, or pelvic regions. Characterized by poor localization and prolonged duration, VP significantly impacts the physical and mental health of patients. Unli...
[Research progress on the neural mechanisms of alcohol use disorder-induced hyperalgesia] [0.03%]
酒精使用障碍诱导痛觉过敏的神经机制研究进展
Ling-Jie Ma,Xiao-Hong Chen,Yong-Jing Gao
Ling-Jie Ma
Alcohol use disorder (AUD) is a complex chronic relapsing brain disease that poses significant threats to individual health and public healthcare systems. Hyperalgesia, an increased sensitivity to pain, has been recognized as a critical fac...
[Research progress on mitochondrial genetic mechanisms underlying the onset of migraine] [0.03%]
migraine的线粒体遗传机制研究进展
Meng-Yuan Qiu,Huai-Lian Guo
Meng-Yuan Qiu
Migraine is a common primary headache disorder in clinical practice, and its recurrent nature severely impairs patients' quality of life. Data from the 2021 Global Burden of Disease Study indicate that migraine imposes a heavy burden on pat...
[Research progress on neurobiological mechanisms of chronic postoperative pain] [0.03%]
慢性术后疼痛的神经生物学机制研究进展
Yi-Qin Wang,Wen-Jing Zhang,Wu-Jun Geng et al.
Yi-Qin Wang et al.
Postoperative pain is a common complication caused by surgical trauma. Epidemiological studies indicate that the incidence of moderate to severe acute postoperative pain ranges from 41% to 85%, with approximately 10% to 50% of patients pote...
[Progress on the mechanism of endocannabinoids involved in electroacupuncture for analgesia and itch relief] [0.03%]
[电针镇痛和止痒的内源大麻素机制研究进展]
Yu-Wei Cao,Ren-Jie Qin,Xiang-Hong Jing et al.
Yu-Wei Cao et al.
Chronic pain and pruritus are significant health challenges that pose major threats to human well-being, with existing therapeutic approaches being limited in their efficacy and scope. Electroacupuncture, as a therapy developed by combining...
[Neuroimmune mechanisms of lipocalin 2 in mediating chronic pain and itch] [0.03%]
神经免疫介质脂联素介导慢性疼痛和瘙痒的机制研究进展
Xia-Lin Cui,Shi-Yu Sun,Jun-Yi Ma et al.
Xia-Lin Cui et al.
Lipocalin 2 (LCN2), a member of the lipocalin superfamily, is expressed and secreted by various cells and functions as a transport protein for lipophilic small molecules such as steroids, lipopolysaccharides, iron and fatty acids. LCN2 play...
New insights into the pain of knee osteoarthritis: the characteristics of deep pain and abnormal central processing [0.03%]
膝骨关节炎疼痛的新见解：深部疼痛的特征及其中枢处理异常
Mu-Lan Chen,Yu-Qing DU,Bo-Yang Xu et al.
Mu-Lan Chen et al.
Knee osteoarthritis (KOA) represents one of the most common causes of chronic pain. The high prevalence and disability rates of KOA impose a severe burden on both individuals and society. In contrast to cutaneous pain, KOA-induced joint pai...
Mechanisms of cancer pain and the multitarget therapeutic potential of Traditional Chinese Medicine [0.03%]
癌症痛的机制及中医药多靶点治疗潜力
Guo-Qun Xu,Ying-Xin Tian,Guang-Yi Si et al.
Guo-Qun Xu et al.
Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies, arising from multifactorial mechanisms involving peripheral, central, and systemic pathways. Conventional analgesics, including opioi...
The dorsal root ganglion T-junction: a critical node in somatosensory processing and pain pathogenesis [0.03%]
背根神经节T型连接：感觉处理和疼痛发病机制中的关键节点
Zhi-He Zhang,Yun-Jie Fu,Yun Wang
Zhi-He Zhang
Pseudounipolar neurons in the dorsal root ganglia (DRG), as the central nodes of primary sensory afferents, possess a distinctive T-junction that is not merely a morphological peculiarity but also performs complex roles in rapid, multiplexe...
[Inhibition of O-GlcNAc transferase alleviates liver pathological changes in spontaneously obese mice] [0.03%]
抑制O-GlcNAc转移酶可缓解自发性肥胖小鼠肝病理变化
Zi-Yang Zhang,Xin-Yu Long,Jia-Yi Zhang et al.
Zi-Yang Zhang et al.
This study was to explore the effects of O-GlcNAc transferase (OGT) inhibition on the liver pathological changes in spontaneously obese mice. Ten 6-week-old male ob/ob mice were randomly divided into a control group and a drug-treated group...