[Research progress on the role of the microbiota-gut-liver axis immune pathway in metabolic dysfunction-associated steatotic liver disease] [0.03%]
菌肠肝轴免疫途径在代谢功能障碍相关性肝脂肪变性疾病中的作用研究进展
Shun-Ling Yuan,Yuan-Qi Huang,Chuang-Tao Li et al.
Shun-Ling Yuan et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widely prevalent chronic liver disease that presents significant challenges to public health and medical care worldwide, yet its underlying mechanisms remain incompletely...
[Molecular mechanism of intervertebral disc cell senescence: telomeres, mitochondria, and cellular metabolic reprogramming] [0.03%]
[分子生物学：椎间盘细胞衰老的分子机制：端粒、线粒体及细胞代谢重塑]
Wei Deng,Ruo-Chen Zhu,Fan-Guo Kong et al.
Wei Deng et al.
Intervertebral disc degeneration (IVDD), as a common spinal disorder, is closely associated with intervertebral disc cell senescence in its pathogenesis. Cellular senescence leads to alterations in the biomechanical properties of interverte...
[Research progress on the regulatory mechanism of ubiquitination on canonical NF-κB signaling pathway] [0.03%]
泛素化修饰调控经典NF-κB信号通路的研究进展
Ying-Ying Jiang,Xiang-Jie Chen,Fang Gong
Ying-Ying Jiang
NF-κB signaling pathway is a key regulatory pathway of inflammation and immune response, and its activation can promote the production of inflammatory factors and inhibit apoptosis. In the canonical NF-κB signaling pathway, ubiquitin modi...
[Research progress on the mechanism of hyodeoxycholic acid in the treatment of MASLD through the gut-liver axis] [0.03%]
猪去氧胆酸通过肠肝轴治疗MASLD的作用机制研究进展
Rui Li,Wen-Qing Shen
Rui Li
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic liver disorder affecting over 30% of the global adult population, with its prevalence and mortality rates continuing to rise. Hyodeoxycholic acid (HDCA), a natu...
[The research progress and outlook on the effects of different exercise modalities on working memory function in middle-aged and elderly individuals] [0.03%]
不同运动模式对中老年人工作记忆功能影响的研究进展与展望
Yi-Kun Zheng,Zu-Lin Chen,Li-Han Lin et al.
Yi-Kun Zheng et al.
This review provides a comprehensive analysis of the effects of different exercise modalities on working memory function in middle-aged and older adults. It systematically reviews evidence from interventions including aerobic exercise, resi...
[Gut-brain axis and Parkinson's disease: research progress on the gut-brain interaction] [0.03%]
[肠脑轴与帕金森病的研究进展]
Yu-Rui Zhao,Hao-Jun You,Jing Lei
Yu-Rui Zhao
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunction. The main pathological manifestations are abnormal accumulation of α-synuclein (α-Syn) in substantia nigra neurons and loss of dopamin...
[Reshaping glycometabolic reprogramming to suppress M1 macrophage polarization for diabetic wound therapy] [0.03%]
[重塑糖代谢重组抑制M1型巨噬细胞极化用于糖尿病创面治疗]
Yue-Yu Xiang,Ai-Tian Zheng,Biao-Liang Wu
Yue-Yu Xiang
Diabetic chronic wounds, a severe diabetic complication, are closely linked to macrophage metabolic reprogramming. Under hyperglycemic conditions, macrophage metabolism shifts from oxidative phosphorylation to aerobic glycolysis, triggering...
[Research progress on hepatokines in metabolic dysfunction-associated steatotic liver disease] [0.03%]
与代谢功能障碍相关脂肪性肝病的肝细胞因子研究进展
Cheng-Ya Huang,Su-Su DU,Wen Zheng et al.
Cheng-Ya Huang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive fat accumulation in the liver resulting from metabolic dysfunction. This condition causes hepatic steatosis and inflammatory injury, representing...
Lin-Sen Wang,Dan Zhou,Xiao Ma et al.
Lin-Sen Wang et al.
Cilia are organelles on the surface of eukaryotic cells, characterized by complex microtubule structures and diverse physiological functions. By sensing external environmental changes, cilia play critical roles in cell movement, signal tran...
[Knockout of LCN2 attenuates lung injury and ferroptosis in septic mice likely through inhibiting the TLR4/NF-κB signaling pathway] [0.03%]
LCN2基因敲除通过抑制TLR4/NF-κB信号通路可能减轻脓毒症小鼠肺损伤和铁死亡
Yi-Ren Wang,Meng-Jie Yu,Ruo-Li DU et al.
Yi-Ren Wang et al.
This study aimed to investigate the effects of lipocalin-2 (LCN2) gene knockout (LCN2KO) on cecal ligation and perforation (CLP)-induced lung injury and ferroptosis in septic mice, and further to clarify the potential role of the Toll-like ...