[Cardiac β-adrenergic receptor regulation of mitochondrial function in heart failure] [0.03%]
心脏β肾上腺素能受体对心力衰竭中心肌细胞线粒体功能调节的作用机制研究
Ai-Ming Liu,Wen-Li Xu,Han Xiao et al.
Ai-Ming Liu et al.
Heart failure is characterized by abnormal β-adrenergic receptor (β-AR) activation and mitochondrial dysfunction. In heart failure, overactivation of β-AR mediates key pathological processes in cardiomyocytes, including oxidative stress,...
[Research progress of the effects of high-intensity interval training on excess post-exercise oxygen consumption in human] [0.03%]
高强度间歇训练对人类过量氧耗的影响研究进展
Yang-Yang Su,Xiao-Ning Dong,Xiu-Qin Wu
Yang-Yang Su
Elevated human metabolism during recovery is associated with increased excess post-exercise oxygen consumption (EPOC). EPOC is linearly related to exercise duration and exponentially related to exercise intensity. It is commonly believed th...
Yi-Fan Guo,Pei-Ji Chen,Wei-Hua Xiao
Yi-Fan Guo
The regulation of adipose tissue homeostasis is essential for maintaining energy and metabolism balance in the body. The peripheral nervous system plays a crucial role in this process. Previous related research primarily focused on the symp...
Ke Han,Zi-Xia Ding,Xiao-Yu He et al.
Ke Han et al.
The etiology of rheumatoid arthritis (RA), a chronic inflammatory systemic disease, remains unclear. It is characterized by symmetrical and invasive joint inflammation, primarily affecting distal small joints such as those in the hands and ...
Zi-Han Wu,Hao-Jun You,Jing Lei
Zi-Han Wu
The kynurenine pathway (KP) is the main metabolic pathway of tryptophan in the diet. Existing research has shown that KP plays a key role in the pathogenesis of various diseases. It has been demonstrated that kynurenine metabolic enzymes, s...
[m6A RNA methylation is a potential biological target for neuropathic pain] [0.03%]
[m6A RNA甲基化可能是一个神经病理性疼痛的生物靶点]
Yu-Ting Zhang,Li-Cai Zhang
Yu-Ting Zhang
N6-methyladenosine (m6A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of met...
[Research progress on the effects of mitochondrial-associated endoplasmic reticulum membranes tethering proteins interaction on cerebral ischemia/reperfusion] [0.03%]
线粒体相关内质网膜固定蛋白相互作用在脑缺血再灌注中的研究进展
Meng-Ling Huang,Li-Hong Zhang,Chang-Yu Gu et al.
Meng-Ling Huang et al.
Cerebral ischemia/reperfusion injury (CIRI) refers to secondary damage caused by reperfusion of blood flow following ischemic stroke. Its mechanism is complex, involving mitochondrial energy metabolism disorders, Ca2+ overload, oxidative st...
[Research progress in the regulation of functional homeostasis of adipose tissue by exosomal miRNA] [0.03%]
外泌体miRNA调控脂肪组织功能稳态的研究进展
Jun-Qing Xu,Meng-Xin Jiang,Ying-Jiang Xu et al.
Jun-Qing Xu et al.
Adipose tissue holds a pivotal position in maintaining systemic energy homeostasis. Brown adipose tissue (BAT) expresses uncoupling protein 1 (UCP1), which is specialized in dissipating chemical energy as heat to maintain euthermia, a proce...
[Research progress on the mechanism of autophagy flow injury caused by lysosomal dysfunction after cerebral ischemia] [0.03%]
缺血性脑损伤后溶酶体功能障碍所致自噬流异常的机制研究进展
Jia-Qian Wang,Hong-Yun He,Yi-Hao Deng
Jia-Qian Wang
Ischemic stroke is an acute cerebrovascular disease caused by cerebral vascular obstruction, which is the third leading cause of human death and disability. Multiple studies have demonstrated that autophagy plays a positive role in neurons ...
[Research progress of human induced pluripotent stem cells in the establishment and application of dilated cardiomyopathy disease model] [0.03%]
人诱导多能干细胞在扩张型心肌病疾病模型建立及应用研究进展
Man-Ting Xie,Bing-Bing Xie,Qiu-Ling Xiang
Man-Ting Xie
Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy with abnormal myocardial structure and function. It is challenging to construct human primary cardiac myocytes from DCM patients due to ethical constraints. In addition, animal m...