Venoms, toxins and derivatives from the Brazilian fauna: valuable sources for drug discovery [0.03%]
来自巴西动物的毒液、毒素和衍生物：药物发现的宝贵资源
Flávia De Marco Almeida,Adriano Monteiro de Castro Pimenta,Mônica Cristina Oliveira et al.
Flávia De Marco Almeida et al.
Animal venoms have been widely investigated throughout the world. The great number of biotechnological articles as well as patent applications in the field of drug discovery based on these compounds indicates how important the source is. Th...
Unique interactions between scorpion toxins and small conductance Ca(2+)-activated potassium channels [0.03%]
蝎毒与小导电钙激活钾通道的特殊相互作用
Fan Yang,Zong-Yun Chen,Ying-Liang Wu
Fan Yang
Small conductance Ca(2+)-activated potassium channels (SK channels) distributing in the nervous system play an important role in learning, memory and synaptic plasticity. Most pharmacological properties of them are determined by short-chain...
Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms [0.03%]
来自蝎子毒液的Shal型（Kv4.x）钾通道孔道阻断剂
Pierre Edouard Bougis,Marie-France Martin-Eauclaire
Pierre Edouard Bougis
Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is ...
Li-Mei Zhu,Bin Gao,Shun-Yi Zhu
Li-Mei Zhu
There are at least three conserved protein folds shared by ion channel-targeted neurotoxins and antimicrobial defensins, including cysteine-stabilized α-helix and β-sheet fold (CSαβ), inhibitor cystine knot fold (ICK) and β-defensin fo...
[Polymethoxylated flavonoids activate cystic fibrosis transmembrane conductance regulator chloride channel] [0.03%]
聚甲氧基黄酮激活囊性纤维化跨膜转导调节因子氯通道
Huan-Huan Cao,Fang Fang,Bo Yu et al.
Huan-Huan Cao et al.
Cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent chloride channel, plays key roles in fluid secretion in serous epithelial cells. Previously, we identified two polymethoxylated flavonoids, 3',4',5,5',6,7-hexameth...
[Study of the change and role of protein C system in ulcerate colitis] [0.03%]
溃疡性结肠炎患者蛋白C系统的变化及其作用机制的研究
Xu-Hong Lin,Hui-Chao Wang,Dan-Dan Wei et al.
Xu-Hong Lin et al.
Hypercoagulable state and thrombosis are major lethal causes of ulcerate colitis (UC). The aim of the present study is to explore the change and role of protein C (PC) system in UC thrombosis. 4% dextran sulfate sodium (DSS) was used to ind...
[The effect of miR-124 on homocysteine-induced atherosclerosis via promoter region DNA methylation in ApoE(-/-) mice] [0.03%]
miR-124通过启动子区域DNA甲基化影响同型半胱氨酸诱导的ApoE基因敲除小鼠动脉粥样硬化的作用研究
Li Zhao,Yun Jiao,An-Ning Yang et al.
Li Zhao et al.
The aim of the present study is to explore the role of miR-124 and its promoter region DNA methylation in homocysteine (Hcy)-induced atherosclerosis. ApoE(-/-) mice were fed with hypermethionine diet for 16 weeks to duplicate hyperhomocyste...
[Combined transgenic inhibition of CaMKII and Ik1 on cardiac remodeling] [0.03%]
钙调神经磷酸酶抑制剂与伊康宁联合转基因抑制心脏重塑
Yun Huang,Miao Dai,Yi-Mei Du et al.
Yun Huang et al.
This study was aimed to establish an experimental mouse model of combined transgenic inhibition of both multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inward rectifier potassium current (Ik1), and to observe whet...
[Involvement of the receptor component protein in the regulation of vascular peroxidase-1 expression induced by calcitonin gene-related peptide and angiotensin II in vascular smooth muscle cell] [0.03%]
降钙素基因相关肽和血管紧张素II诱导血管平滑肌细胞中血管过氧化物酶-1表达调控的受体成分蛋白参与作用研究
Yan-Mei Liu,Hong-Yan Peng,Feng Guo et al.
Yan-Mei Liu et al.
Angiotensin II (Ang II) and calcitonin gene-related peptide (CGRP) play important roles in vascular injury and protection. In order to determine the role of CGRP receptor component protein (RCP) in signal transduction whereby CGRP and Ang I...
[Role and mechanism of all-trans retinoic acid in up-regulating apelin expression in vascular smooth muscle cells] [0.03%]
全反式维甲酸上调血管平滑肌细胞中apelin表达的作用及机制研究
Xin-Rui Lv,Bao-Hui Wang,Ming-Liang Chen et al.
Xin-Rui Lv et al.
This study was aimed to investigate the mechanism of all-trans retinoic acid (ATRA) up-regulating apelin expression in vascular smooth muscle cells (VSMCs). The effect of ATRA on apelin expression in the VSMCs was investigated by RT-PCR, re...