Relationship of immune response with intestinal flora and metabolic reprogramming in patients with non-small cell lung cancer [0.03%]
非小细胞肺癌患者免疫反应与肠道菌群及代谢重编程的关系研究
Rui Guo,Zhe He,Fan Liu et al.
Rui Guo et al.
Numerous research conducted in recent years has revealed that gut microbial dysbiosis, such as modifications in composition and activity, might influence lung tissue homeostasis through specific pathways, thereby promoting susceptibility to...
Yi-Ling Luo,Liu-Yan Chen,Yao-Bin Wang et al.
Yi-Ling Luo et al.
PANoptosis is a type of programmed cell death regulated by the PANoptosome with key features of pyroptosis, apoptosis and/or necroptosis. As the most complex programmed cell death, PANoptosis emphasizes the compensatory role among multiple ...
Lei-Rong Gu,Hui Zhang,Juan Chen et al.
Lei-Rong Gu et al.
Malignant proliferating liver cancer cells possess the ability to detect and respond to various body signals, thereby facilitating tumor growth, invasion, and metastasis. One crucial mechanism through which hepatocellular carcinoma (HCC) ce...
[CXCR3 counteracts cisplatin-induced muscle atrophy by regulating E3 ubiquitin ligases, myogenic factors, and fatty acid β-oxidation pathways] [0.03%]
CXCR3通过调节E3泛素连接酶、肌源性因子和脂肪酸β氧化途径对抗顺铂诱导的肌肉萎缩
Miao-Miao Xu,Xiao-Guang Liu,Li-Ming Lu et al.
Miao-Miao Xu et al.
This study aims to explore the role and mechanism of CXC chemokine receptor 3 (CXCR3) in cisplatin-induced skeletal muscle atrophy. Wild-type mice were divided into two groups: cisplatin group and control group (treated by normal saline). T...
[c-Met-targeted chimeric antigen receptor T cells inhibit human serous ovarian cancer cell SKOV-3 in vitro] [0.03%]
针对c-Met的嵌合抗原受体T细胞在体外抑制人浆液性卵巢癌SKOV-3细胞
Na-Na DU,Yan-Jun Zhang,Yan-Qiu Li et al.
Na-Na DU et al.
The study aimed to construct the second and third generation chimeric antigen receptor T cells (CAR-T) targeting the c-mesenchymal-epithelial transition factor (c-Met) protein, and observe their killing effect on human serous ovarian cancer...
[Cold stimulation regulates lipid metabolism and the secretion of exosomes from subcutaneous adipose tissue in mice] [0.03%]
冷刺激通过调节小鼠皮下脂肪组织脂质代谢及外泌体分泌发挥作用
Shuo Ke,Li Xu,Rui-Xue Shi et al.
Shuo Ke et al.
Cold has been a long-term survival challenge in the evolutionary process of mammals. In response to cold stress, in addition to brown adipose tissue (BAT) dissipating energy as heat through glucose and lipid oxidation to maintain body tempe...
[Disulfiram alleviates cardiac hypertrophic injury by inhibiting TAK1-mediated PANoptosis] [0.03%]
硫胺素通过抑制TAK1介导的PANoptosis缓解心脏肥大损伤
Wei-Dong Li,Xuan-Yang Shen,Xiao-Lu Jiang et al.
Wei-Dong Li et al.
The study aims to examine the effects and potential mechanisms of disulfiram (DSF) on cardiac hypertrophic injury, focusing on the role of transforming growth factor-β-activated kinase 1 (TAK1)-mediated pan-apoptosis (PANoptosis). H9C2 car...
[Transcriptomic analysis of key genes involved in sex differences in intellectual development] [0.03%]
[参与智力发育性别差异的关键基因的转录组分析]
Jia-Wei Zhang,Xiao-Li Zheng,Hai-Qian Zhou et al.
Jia-Wei Zhang et al.
Intelligence encompasses various abilities, including logical reasoning, comprehension, self-awareness, learning, planning, creativity, and problem-solving. Extensive research and practical experience suggest that there are sex differences ...
[Research progress on NCOA4-mediated ferritinophagy and related diseases] [0.03%]
NCOA4介导的铁蛋白自噬及其相关疾病的研究进展
Chen Jia,Hong-Ji Lin,Fang Cui et al.
Chen Jia et al.
Nuclear receptor co-activator 4 (NCOA4) acts as a selective cargo receptor that binds to ferritin, a cytoplasmic iron storage complex. By mediating ferritinophagy, NCOA4 regulates iron metabolism and releases free iron in the body, thus pla...
[Advances in application of small-molecule compounds in neuronal reprogramming] [0.03%]
小分子化合物在神经元重编程中应用的进展
Zi-Wei Dai,Hong Liu,Yi-Min Yuan et al.
Zi-Wei Dai et al.
Neuronal reprogramming is an innovative technique for converting non-neuronal somatic cells into neurons that can be used to replace lost or damaged neurons, providing a potential effective therapeutic strategy for central nervous system (C...