Conserved translational control in cardiac hypertrophy revealed by ribosome profiling [0.03%]
基于核糖体谱分析揭示心室肥厚中保守的翻译调控机制
Bao-Sen Wang,Jian Lyu,Hong-Chao Zhan et al.
Bao-Sen Wang et al.
A primary hallmark of pathological cardiac hypertrophy is excess protein synthesis due to enhanced translational activity. However, regulatory mechanisms at the translational level under cardiac stress remain poorly understood. Here we exam...
[Effects of resistance combined with aerobic chrono-exercise on common carotid artery elasticity and hemodynamics in young men] [0.03%]
抵抗运动结合有氧时序锻炼对青年男性颈总动脉弹性及血流动力学的影响
Miao-Xin Jiao,Bing-Yi Shen,Hai-Bin Liu et al.
Miao-Xin Jiao et al.
The purpose of the present study was to investigate the effects of resistance combined with aerobic chrono-exercise on the common carotid artery elasticity and hemodynamics. 24 healthy young men (21.96±0.43 years old) underwent a single ac...
[Misaligned light entrainment causes metabolic disorders in Chrono knockout mice] [0.03%]
[时差基因敲除小鼠光照同步失谐引起代谢障碍]
Ruo-Han Wang,Shao-Ying Lan,Bo-Yuan Cao et al.
Ruo-Han Wang et al.
Most of the life forms on Earth have gradually evolved an endogenous biological clock under the long-term influence of periodic daily light-dark cycles. This biological clock system plays a crucial role in the orderly progression of life ac...
Bing-Xin Gao,Cao Wang,Rui-Xian Jiang et al.
Bing-Xin Gao et al.
In recent years, China's manned space program has advanced rapidly, with deep space exploration missions such as manned lunar landing steadily progressing, leading to a significant extension of astronauts' duration in outer space. In this c...
[Circadian and non-circadian regulation of the male reproductive system and reproductive damage: advances in the role and mechanisms of clock genes] [0.03%]
[生物钟基因在昼夜和非昼夜节律调节男性生殖系统及生殖损害作用与机制的研究进展]
Meng-Chao He,Ying-Zhong Dai,Yi-Meng Wang et al.
Meng-Chao He et al.
Recently, male reproductive health has attracted extensive attention, with the adverse effects of circadian disruption on male fertility gradually gaining recognition. However, the mechanism by which circadian disruption leads to damage to ...
Circadian rhythms and their roles in the pathogenesis and treatment of depression [0.03%]
生物节律与抑郁症发病机制及治疗反应的关系
William Kojo Smith,Zhao-Min Zhong,Willow Tsanzi Wang et al.
William Kojo Smith et al.
Major depressive disorder (MDD) affects people all over the world, and yet, its etiology is complex and remains incompletely understood. In this review, we aim to assess recent advances in understanding depression and its regulation, as wel...
Deng-Feng Liu,Yi-Chun Zhang,Jia-Da Li
Deng-Feng Liu
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intellectual developmental disorder (IDD), are highly prevalent and lack effective treatments, posing signif...
[Research progress of the interaction between RAAS and clock genes in cardiovascular diseases] [0.03%]
心血管疾病中RAAS与钟基因互作的研究进展
Rui-Ling Ma,Yi-Yuan Wang,Yu-Shun Kou et al.
Rui-Ling Ma et al.
The renin-angiotensin-aldosterone system (RAAS) is crucial for regulating blood pressure and maintaining fluid balance, while clock genes are essential for sustaining biological rhythms and regulating metabolism. There exists a complex inte...
[Research advances in the mechanisms of circadian regulation in heart failure] [0.03%]
心力衰竭circadian节律调控机制研究进展
Qiong Wang,Jia-Yang Zhang,Le-Jia Qiu et al.
Qiong Wang et al.
The circadian clock is an endogenous time-keeping system that maintains physiological homeostasis by integrating environmental and genetic interactions. Heart failure is a complex clinical syndrome characterized by structural abnormalities ...
[Research progress on biological clock-targeting small-molecule compounds for intervention in metabolic diseases] [0.03%]
生物钟调控代谢的小分子化合物研究进展
Qing-Qing Wang,Chang Liu
Qing-Qing Wang
The circadian rhythm regulates the 24-hour physiological and behavioral cycles through endogenous molecular clocks governed by core clock genes via the transcription-translation feedback loop (TTFL). In mammals, the suprachiasmatic nucleus ...